Neuroscience

Articles and news from the latest research reports.

Posts tagged working memory

79 notes

Tickling the Brain with Magnetic Stimulation Improves Memory in Schizophrenia

Cognitive impairments are disabling for individuals with schizophrenia, and no satisfactory treatments currently exist. These impairments affect a wide range of cognition, including memory, attention, verbal and motor skills, and IQ. They appear in the earliest stages of the disease and disrupt or even prevent normal day-to-day functioning.

Scientists are exploring a variety of strategies to reduce these impairments including “exercising the brain” with specially designed computer games and medications that might improve the function of brain circuits.

In this issue of Biological Psychiatry, Dr. Mera Barr and her colleagues at University of Toronto provide new evidence that stimulating the brain using repetitive transcranial magnetic stimulation (rTMS) may be an effective strategy to improve cognitive function.

“In a randomized controlled trial, we evaluated whether rTMS can improve working memory in schizophrenia,” said Barr and senior author Dr. Zafiris Daskalakis. “Our results showed that rTMS resulted in a significant improvement in working memory performance relative to baseline.”

Transcranial magnetic stimulation is a non-invasive procedure that uses magnetic fields to stimulate nerve cells. It does not require sedation or anesthesia and so patients remain awake, reclined in a chair, while treatment is administered through coils placed near the forehead.

“TMS can have lasting effects on brain circuit function because this approach not only changes the activity of the circuit that is being stimulated, but it also may change the plasticity of that circuit, i.e., the capacity of the circuit to remodel itself functionally and structurally to support cognitive functions,” explained Dr. John Krystal, Editor of Biological Psychiatry.

Previous work has shown that rTMS improves working memory in healthy individuals and a recent open-label trial showed promising findings for verbal memory in schizophrenia patients. This series of findings led this study to determine if high frequency rTMS could improve memory in individuals with schizophrenia.

They recruited medicated schizophrenia patients who completed a working memory task before and after 4 weeks of treatment. Importantly, this was a double-blind study, where neither the patients nor the researchers knew who was receiving real rTMS or a sham treatment that was designed to entirely mimic the procedure without actually delivering brain stimulation.

rTMS not only improved working memory in patients after 4 weeks, but the improvement was to a level comparable to healthy subjects. These findings suggest that rTMS may be a novel, efficacious, and safe treatment for working memory deficits in schizophrenia.

In 2008, rTMS was FDA-approved to treat depression for individuals who don’t respond to pharmacotherapy. The hope is that additional research will replicate these findings and finally provide an approved treatment for cognitive impairments in schizophrenia.

The authors concluded: “Working memory is an important predictor of functional outcome. Developing novel treatments aimed at improving these deficits may ultimately translate into meaningful changes in the lives of patients suffering from this debilitating disorder.”

(Source: elsevier.com)

Filed under rTMS transcranial magnetic stimulation brain circuits cognitive function working memory schizophrenia psychology neuroscience science

122 notes

Bilingual children have a better “working memory” than monolingual children
A study conducted at the University of Granada and the University of York in Toronto, Canada, has revealed that bilingual children develop a better working memory –which holds, processes and updates information over short periods of time– than monolingual children. The working memory plays a major role in the execution of a wide range of activities, such as mental calculation (since we have to remember numbers and operate with them) or reading comprehension (given that it requires associating the successive concepts in a text).
The objective of this study –which was published in the last issue of the Journal of Experimental Child Psychology– was examining how multilingualism influences the development of the “working memory” and investigating the association between the working memory and the cognitive superiority of bilingual people found in previous studies.
Executive Functions
The working memory includes the structures and processes associated with the storage and processing of information over short periods of time. It is one of the components of the so-called “executive functions”: a set of mechanisms involved in the planning and self-regulation of human behavior. Although the working memory is developed in the first years of life, it can be trained and improved with experience.
According to the principal investigator of this study, Julia Morales Castillo, of the Department of Experimental Psychology of the University of Granada, this study contributes to better understand cognitive development in bilingual and monolingual children. “Other studies have demonstrated that bilingual children are better at planning and cognitive control (i.e. tasks involving ignoring irrelevant information or requiring a dominant response). But, to date, there was no evidence on the influence of bilingualism on the working memory.
The study sample included bilingual children between 5 and 7 years of age (a critical period in the development of the working memory). The researchers found that bilingual children performed better than monolingual children in working memory tasks. Indeed, the more complex the tasks the better their performance. “The results of this study suggest that bilingualism does not only improve the working memory in an isolated way, but they affect the global development of executive functions, especially when they have to interact with each other”, Morales Castillo states.
Music Education
According to the researcher, the results of this study “contribute to the growing number of studies on the role of experience in cognitive development”. Other studies have demonstrated that children performing activities such as music education have better cognitive capacities. “However, we cannot determine to what extent children perform these activities due to other factors such as talent or personal interest”.
“However, the children in our study were bilingual because of family reasons rather than because of an interest in languages.

Bilingual children have a better “working memory” than monolingual children

A study conducted at the University of Granada and the University of York in Toronto, Canada, has revealed that bilingual children develop a better working memory –which holds, processes and updates information over short periods of time– than monolingual children. The working memory plays a major role in the execution of a wide range of activities, such as mental calculation (since we have to remember numbers and operate with them) or reading comprehension (given that it requires associating the successive concepts in a text).

The objective of this study –which was published in the last issue of the Journal of Experimental Child Psychology– was examining how multilingualism influences the development of the “working memory” and investigating the association between the working memory and the cognitive superiority of bilingual people found in previous studies.

Executive Functions

The working memory includes the structures and processes associated with the storage and processing of information over short periods of time. It is one of the components of the so-called “executive functions”: a set of mechanisms involved in the planning and self-regulation of human behavior. Although the working memory is developed in the first years of life, it can be trained and improved with experience.

According to the principal investigator of this study, Julia Morales Castillo, of the Department of Experimental Psychology of the University of Granada, this study contributes to better understand cognitive development in bilingual and monolingual children. “Other studies have demonstrated that bilingual children are better at planning and cognitive control (i.e. tasks involving ignoring irrelevant information or requiring a dominant response). But, to date, there was no evidence on the influence of bilingualism on the working memory.

The study sample included bilingual children between 5 and 7 years of age (a critical period in the development of the working memory). The researchers found that bilingual children performed better than monolingual children in working memory tasks. Indeed, the more complex the tasks the better their performance. “The results of this study suggest that bilingualism does not only improve the working memory in an isolated way, but they affect the global development of executive functions, especially when they have to interact with each other”, Morales Castillo states.

Music Education

According to the researcher, the results of this study “contribute to the growing number of studies on the role of experience in cognitive development”. Other studies have demonstrated that children performing activities such as music education have better cognitive capacities. “However, we cannot determine to what extent children perform these activities due to other factors such as talent or personal interest”.

“However, the children in our study were bilingual because of family reasons rather than because of an interest in languages.

Filed under children cognitive development bilingualism working memory neuroscience psychology science

478 notes

Chimpanzees have faster working memory than humans
Chimpanzees have a faster working memory than humans according to a remarkable study showing that it takes them a fraction of a second to remember something that it would take several seconds for humans to memorise. 
A Japanese scientist has demonstrated the prowess of chimps in remembering in less than half a second the precise position and correct sequence of up to nine numbers on a computer screen.
The numbers are shown together randomly distributed on a computer screen and as soon as the chimps press the number “one” the rest of the numerals are masked. However, they can almost invariably remember where each number was.
It is impossible for people to do the same cognitive task that quickly, said Tetsuro Matsuzawa, a primatologist at Kyoto University. “They have a better working memory than us,” he told the American Association for the Advancment of Science meeting in Boston.
Professor Matsuzawa had carried out the memory experiments on a female chimp called Ai, which means “love” in Japanese, and Ayumu, her son who was born in 2000 and has shown even better memory skills, he said.
Professor Matsuzawa suggested that chimps have developed this part of their memory because they live in the “here and now” whereas humans are thinking more about the past and planning for the future.

Chimpanzees have faster working memory than humans

Chimpanzees have a faster working memory than humans according to a remarkable study showing that it takes them a fraction of a second to remember something that it would take several seconds for humans to memorise.

A Japanese scientist has demonstrated the prowess of chimps in remembering in less than half a second the precise position and correct sequence of up to nine numbers on a computer screen.

The numbers are shown together randomly distributed on a computer screen and as soon as the chimps press the number “one” the rest of the numerals are masked. However, they can almost invariably remember where each number was.

It is impossible for people to do the same cognitive task that quickly, said Tetsuro Matsuzawa, a primatologist at Kyoto University. “They have a better working memory than us,” he told the American Association for the Advancment of Science meeting in Boston.

Professor Matsuzawa had carried out the memory experiments on a female chimp called Ai, which means “love” in Japanese, and Ayumu, her son who was born in 2000 and has shown even better memory skills, he said.

Professor Matsuzawa suggested that chimps have developed this part of their memory because they live in the “here and now” whereas humans are thinking more about the past and planning for the future.

Filed under primates memory working memory cognitive tasks psychology neuroscience science

483 notes

Study Shows Working Memory Is Driven By Prefrontal Cortex And Dopamine
One of the unique features of the human mind is its ability re-prioritize its goals and priorities as situations change and new information arises. This happens when you cancel a planned cruise because you need the money to repair your broke-down car, or when you interrupt your morning jog because your cell phone is ringing in your pocket.
In a new study published in the Proceedings of the National Academy of Sciences (PNAS), researchers from Princeton University say that they have discovered the mechanisms that control how our brains use new information to modify our existing priorities.
The team of researchers at Princeton’s Neuroscience Institute (PNI) used functional magnetic resonance imaging (fMRI) to scan subjects and find out where and how the human brain reprioritizes goals. Unsurprisingly, they found that the shifting of goals takes place in the prefrontal cortex, a region of the brain which is known to be associated with a variety of higher-level behaviors. They also observed that the powerful neurotransmitter dopamine – also known as the “pleasure chemical” – appears to play a critical role in this process.
Using a harmless magnetic pulse, the scientists interrupted activity in the prefrontal cortex of the participants while they were playing games and found they were unable to switch to a different task in the game.
“We have found a fundamental mechanism that contributes to the brain’s ability to concentrate on one task and then flexibly switch to another task,” explained Jonathan Cohen, co-director of PNI and the university’s Robert Bendheim and Lynn Bendheim Thoman Professor in Neuroscience.
“Impairments in this system are central to many critical disorders of cognitive function such as those observed in schizophrenia and obsessive-compulsive disorder.”
Previous research had already demonstrated that when the brain uses new information to modify its goals or behaviors, this information is temporarily filed away into the brain’s working memory, a type of short-term memory storage. Until now, however, scientists have not understood the mechanisms controlling how this information is updated.

Study Shows Working Memory Is Driven By Prefrontal Cortex And Dopamine

One of the unique features of the human mind is its ability re-prioritize its goals and priorities as situations change and new information arises. This happens when you cancel a planned cruise because you need the money to repair your broke-down car, or when you interrupt your morning jog because your cell phone is ringing in your pocket.

In a new study published in the Proceedings of the National Academy of Sciences (PNAS), researchers from Princeton University say that they have discovered the mechanisms that control how our brains use new information to modify our existing priorities.

The team of researchers at Princeton’s Neuroscience Institute (PNI) used functional magnetic resonance imaging (fMRI) to scan subjects and find out where and how the human brain reprioritizes goals. Unsurprisingly, they found that the shifting of goals takes place in the prefrontal cortex, a region of the brain which is known to be associated with a variety of higher-level behaviors. They also observed that the powerful neurotransmitter dopamine – also known as the “pleasure chemical” – appears to play a critical role in this process.

Using a harmless magnetic pulse, the scientists interrupted activity in the prefrontal cortex of the participants while they were playing games and found they were unable to switch to a different task in the game.

“We have found a fundamental mechanism that contributes to the brain’s ability to concentrate on one task and then flexibly switch to another task,” explained Jonathan Cohen, co-director of PNI and the university’s Robert Bendheim and Lynn Bendheim Thoman Professor in Neuroscience.

“Impairments in this system are central to many critical disorders of cognitive function such as those observed in schizophrenia and obsessive-compulsive disorder.”

Previous research had already demonstrated that when the brain uses new information to modify its goals or behaviors, this information is temporarily filed away into the brain’s working memory, a type of short-term memory storage. Until now, however, scientists have not understood the mechanisms controlling how this information is updated.

Filed under brain prefrontal cortex working memory OCD dopamine neuroscience science

259 notes


Making Memories: Drexel Researchers Explore the Anatomy of Recollection
What was your high school mascot? Where did you put your keys last night? Who was the first president of the United States?
Groups of neurons in your brain are currently sending electromagnetic rhythms through established pathways in order for you to recall the answers to each of these questions. Researchers in Drexel’s School of Biomedical Engineering, Science and Health Systems are now getting a rare look inside the brain to discover the exact pattern of activity that produces a memory.
Dr. Joshua Jacobs, a professor in Drexel’s School of Biomedical Engineering, Science and Health Systems, is analyzing data accumulated from 60 epilepsy patients who have had electrodes implanted on their brains in order to determine the causes of their epileptic episodes.
"When performing seizure mapping, surgeons implant electrodes in many brain areas, while searching for seizure activity,” Jacobs said. “Thus, there many electrodes end up being in normal brain tissue, and they measure neuronal activity that reflects normal brain function – this is the function that we’re studying to learn about the nature of working memory."

Read more

Making Memories: Drexel Researchers Explore the Anatomy of Recollection

What was your high school mascot? Where did you put your keys last night? Who was the first president of the United States?

Groups of neurons in your brain are currently sending electromagnetic rhythms through established pathways in order for you to recall the answers to each of these questions. Researchers in Drexel’s School of Biomedical Engineering, Science and Health Systems are now getting a rare look inside the brain to discover the exact pattern of activity that produces a memory.

Dr. Joshua Jacobs, a professor in Drexel’s School of Biomedical Engineering, Science and Health Systems, is analyzing data accumulated from 60 epilepsy patients who have had electrodes implanted on their brains in order to determine the causes of their epileptic episodes.

"When performing seizure mapping, surgeons implant electrodes in many brain areas, while searching for seizure activity,” Jacobs said. “Thus, there many electrodes end up being in normal brain tissue, and they measure neuronal activity that reflects normal brain function – this is the function that we’re studying to learn about the nature of working memory."

Read more

Filed under brain brain activity memory working memory seizure activity neuroscience psychology science

49 notes

Brain’s Code for Visual Working Memory Deciphered in Monkeys
The brain holds in mind what has just been seen by synchronizing brain waves in a working memory circuit, an animal study supported by the National Institutes of Health suggests. The more in-sync such electrical signals of neurons were in two key hubs of the circuit, the more those cells held the short-term memory of a just-seen object.
Charles Gray, Ph.D., of Montana State University, Bozeman, a grantee of NIH’s National Institute of Mental Health (NIMH), and colleagues, report their findings Nov. 1, 2012, online, in the journal Science Express.
“This work demonstrates, for the first time, that there is information about short term memories reflected in in-sync brainwaves,” explained Gray.
“The Holy Grail of neuroscience has been to understand how and where information is encoded in the brain. This study provides more evidence that large scale electrical oscillations across distant brain regions may carry information for visual memories,” said NIMH director Thomas R. Insel, M.D.
Prior to the study, scientists had observed synchronous patterns of electrical activity between the two circuit hubs after a monkey saw an object, but weren’t sure if the signals actually represent such short-term visual memories in the brain. Rather, it was thought that such neural oscillations might play the role of a traffic cop, directing information along brain highways.

Brain’s Code for Visual Working Memory Deciphered in Monkeys

The brain holds in mind what has just been seen by synchronizing brain waves in a working memory circuit, an animal study supported by the National Institutes of Health suggests. The more in-sync such electrical signals of neurons were in two key hubs of the circuit, the more those cells held the short-term memory of a just-seen object.

Charles Gray, Ph.D., of Montana State University, Bozeman, a grantee of NIH’s National Institute of Mental Health (NIMH), and colleagues, report their findings Nov. 1, 2012, online, in the journal Science Express.

“This work demonstrates, for the first time, that there is information about short term memories reflected in in-sync brainwaves,” explained Gray.

“The Holy Grail of neuroscience has been to understand how and where information is encoded in the brain. This study provides more evidence that large scale electrical oscillations across distant brain regions may carry information for visual memories,” said NIMH director Thomas R. Insel, M.D.

Prior to the study, scientists had observed synchronous patterns of electrical activity between the two circuit hubs after a monkey saw an object, but weren’t sure if the signals actually represent such short-term visual memories in the brain. Rather, it was thought that such neural oscillations might play the role of a traffic cop, directing information along brain highways.

Filed under brain brainwaves working memory visual memories STM neuroscience psychology science

271 notes


Omega-3 Intake Heightens Working Memory in Healthy Young Adults
While Omega-3 essential fatty acids—found in foods like wild fish and grass-fed livestock—are necessary for human body functioning, their effects on the working memory of healthy young adults have not been studied until now.
In the first study of its kind, researchers at the University of Pittsburgh have determined that healthy young adults ages 18-25 can improve their working memory even further by increasing their Omega-3 fatty acid intake. Their findings have been published online in PLOS One. 
“Before seeing this data, I would have said it was impossible to move young healthy individuals above their cognitive best,” said Bita Moghaddam, project investigator and professor of neuroscience. “We found that members of this population can enhance their working memory performance even further, despite their already being at the top of their cognitive game.”

Read more
(Image credit: Matt Allworth/Courtesy Flickr)

Omega-3 Intake Heightens Working Memory in Healthy Young Adults

While Omega-3 essential fatty acids—found in foods like wild fish and grass-fed livestock—are necessary for human body functioning, their effects on the working memory of healthy young adults have not been studied until now.

In the first study of its kind, researchers at the University of Pittsburgh have determined that healthy young adults ages 18-25 can improve their working memory even further by increasing their Omega-3 fatty acid intake. Their findings have been published online in PLOS One

“Before seeing this data, I would have said it was impossible to move young healthy individuals above their cognitive best,” said Bita Moghaddam, project investigator and professor of neuroscience. “We found that members of this population can enhance their working memory performance even further, despite their already being at the top of their cognitive game.”

Read more

(Image credit: Matt Allworth/Courtesy Flickr)

Filed under brain performance memory working memory omega-3 cognitive abilities neuroscience psychology science

112 notes


Studies report early childhood trauma takes visible toll on brain; changes found in regions controlling heart and behavior
Trauma in infancy and childhood shapes the brain, learning, and behavior, and fuels changes that can last a lifetime, according to new human and animal research released today. The studies delve into the effects of early physical abuse, socioeconomic status (SES), and maternal treatment. Documenting the impact of early trauma on brain circuitry and volume, the activation of genes, and working memory, researchers suggest it increases the risk of mental disorders, as well as heart disease and stress-related conditions in adulthood.
Today’s findings show:
• Physical abuse in early childhood may realign communication between key “body-control” brain areas, possibly predisposing adults to cardiovascular disease and mental health problems (Layla Banihashemi, PhD, abstract 691.12).  • Rodent studies provide insight into brain changes that allow tolerance of pain within mother-pup attachment (Regina Sullivan, PhD, abstract 399.19).  • Childhood poverty is associated with changes in working memory and attention years later in adults; yet training in childhood is associated with improved cognitive functions (Eric Pakulak, PhD, abstract 908.04).  • Chronic stress experienced by infant primates leads to fearful and aggressive behaviors; these are associated with changes in stress hormone production and in the development of the amygdala (Mar Sanchez, PhD, abstract 691.10).
Another recent finding discussed shows that:  • Parent education and income is associated with children’s brain size, including structures important for memory and emotion (Suzanne Houston, MA).

Studies report early childhood trauma takes visible toll on brain; changes found in regions controlling heart and behavior

Trauma in infancy and childhood shapes the brain, learning, and behavior, and fuels changes that can last a lifetime, according to new human and animal research released today. The studies delve into the effects of early physical abuse, socioeconomic status (SES), and maternal treatment. Documenting the impact of early trauma on brain circuitry and volume, the activation of genes, and working memory, researchers suggest it increases the risk of mental disorders, as well as heart disease and stress-related conditions in adulthood.

Today’s findings show:

• Physical abuse in early childhood may realign communication between key “body-control” brain areas, possibly predisposing adults to cardiovascular disease and mental health problems (Layla Banihashemi, PhD, abstract 691.12).
• Rodent studies provide insight into brain changes that allow tolerance of pain within mother-pup attachment (Regina Sullivan, PhD, abstract 399.19).
• Childhood poverty is associated with changes in working memory and attention years later in adults; yet training in childhood is associated with improved cognitive functions (Eric Pakulak, PhD, abstract 908.04).
• Chronic stress experienced by infant primates leads to fearful and aggressive behaviors; these are associated with changes in stress hormone production and in the development of the amygdala (Mar Sanchez, PhD, abstract 691.10).

Another recent finding discussed shows that:
• Parent education and income is associated with children’s brain size, including structures important for memory and emotion (Suzanne Houston, MA).

Filed under brain childhood trauma working memory stress physical abuse Neuroscience 2012 neuroscience psychology science

161 notes


Alpha Waves Close Your Mind for Distraction, but Not Continuously, Research Suggests
Alpha waves were long ignored, but gained interest of brain researchers recently. Electrical activity of groups of brain cells results in brain waves with different amplitudes. The so-called alpha wave, a slow brain wave with a cycle of 100 milliseconds, seems to play a key role in suppressing irrelevant brain activity. The current hypothesis is that this alpha wave is associated with pulses of inhibition (every 100 ms) in the brain.
Mathilde Bonnefond and Ole Jensen (Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen) discovered that when distracting information can be anticipated in time there is an increase of the power of this alpha wave just before the distracter. Furthermore, the brain is able to precisely control the alpha wave so that the pulse of inhibition is maximal when the distracter appears. Indeed, between pulses of inhibition, there is still a window where the brain is excitable.
'It is like briefly opening a door to look what's happening outside. This enables us to detect an unexpected but important or dangerous event. But to avoid to be distracted by completely irrelevant information, it is better if the inhibition is active when a distracter is presented. It could be seen as a mechanism slamming the door of the brain on intruders'. The results are published by the scientific journal Current Biology at October 4.

Alpha Waves Close Your Mind for Distraction, but Not Continuously, Research Suggests

Alpha waves were long ignored, but gained interest of brain researchers recently. Electrical activity of groups of brain cells results in brain waves with different amplitudes. The so-called alpha wave, a slow brain wave with a cycle of 100 milliseconds, seems to play a key role in suppressing irrelevant brain activity. The current hypothesis is that this alpha wave is associated with pulses of inhibition (every 100 ms) in the brain.

Mathilde Bonnefond and Ole Jensen (Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen) discovered that when distracting information can be anticipated in time there is an increase of the power of this alpha wave just before the distracter. Furthermore, the brain is able to precisely control the alpha wave so that the pulse of inhibition is maximal when the distracter appears. Indeed, between pulses of inhibition, there is still a window where the brain is excitable.

'It is like briefly opening a door to look what's happening outside. This enables us to detect an unexpected but important or dangerous event. But to avoid to be distracted by completely irrelevant information, it is better if the inhibition is active when a distracter is presented. It could be seen as a mechanism slamming the door of the brain on intruders'. The results are published by the scientific journal Current Biology at October 4.

Filed under brain brainwaves alpha waves working memory oscillations neuroscience psychology science

free counters