Researchers Confirm the “Pinocchio Effect”: When you Lie, your Nose Temperature Raises

When a person lies they suffer a “Pinocchio effect”, which is an increase in the temperature around the nose and in the orbital muscle in the inner corner of the eye. In addition, when we perform a considerable mental effort our face temperature drops and when we have an anxiety attack our face temperature raises. These are some of the conclusions drawn in this pioneer study conducted at the University of Granada Department of Experimental Psychology, which has introduced new applications of thermography.

Excitement is the Same in Men and Women

Sexual excitement and desire can be identified in men and women using thermography, since they induce an increase in chest and genital temperature. This study demonstrates that –in physiological terms– men and women get excited at the same time, even although women say they are not excited or only slightly excited.

When we lie on our feelings, the temperature around our nose raises and a brain element called “insula” is activated. The insula is a component of the brain reward system, and it only activates when we experience real feelings (called “qualias”). "The insula is involved in the detection and regulation of body temperature. Therefore, there is a strong negative correlation between insula activity and temperature increase: the more active the insule (the greater the feeling) the lower the temperature change, and viceversa", the researchers state.

The Thermal Footprint of Flamenco

Researchers also determined the thermal footprint of aerobic exercise and different dance modalities such as ballet. "When a person is dancing flamenco the temperature in their buttocks drops and increases in their forearms. That is the thermal footprint of flamenco, and each dance modality has a specific thermal footprint”, professor Salazar explains.

The researchers have demonstrated that temperature asymmetries in both sides of the body and local temperature changes are associated with the physical, mental and emotional status of the subject. "The thermogram is a somatic marker of subjective or mental states and allows us see what a person is feeling or thinking”, professor Salazar states.

Dopamine Not About Pleasure (Anymore)

To John Salamone, professor of psychology and longtime researcher of the brain chemical dopamine, scientific research can be very slow-moving.

“It takes a long time for things to change in science,” he says. “It’s like pulling on the steering wheel of an ocean liner, then waiting for the huge ship to slowly turn.”

Salamone has spent most of his career battling a particular long-held scientific idea: the popular notion that high levels of brain dopamine are related to experiences of pleasure. As increasing numbers of studies show, he says, the famous neurotransmitter is not responsible for pleasure, but has to do with motivation.

He summarizes and comments on the evidence for this shift in thinking in a Nov. 8 review in the Cell Press journal Neuron.

Novel Antibodies for Combating Alzheimer’s and Parkinson’s Disease

Antibodies developed by researchers at Rensselaer Polytechnic Institute are unusually effective at preventing the formation of toxic protein particles linked to Alzheimer’s disease and Parkinson’s disease, as well as Type 2 diabetes, according to a new study.

The onset of these devastating diseases is associated with the inappropriate clumping of proteins into particles that are harmful to cells in the brain (Alzheimer’s disease and Parkinson’s disease) and pancreas (Type 2 diabetes). Antibodies, which are commonly used by the immune system to target foreign invaders such as bacteria and viruses, are promising weapons for preventing the formation of toxic protein particles. A limitation of conventional antibodies, however, is that high concentrations are required to completely inhibit the formation of toxic protein particles in Alzheimer’s, Parkinson’s, and other disorders.

To address this limitation, a team of researchers led by Rensselaer Professor Peter Tessier has developed a new process for creating antibodies that potently inhibit formation of toxic protein particles. Conventional antibodies typically bind to one or two target proteins per antibody. Antibodies created using Tessier’s method, however, bind to 10 proteins per antibody. The increased potency enables the novel antibodies to prevent the formation of toxic protein particles at unusually low concentrations. This is an important step toward creating new therapeutic molecules for preventing diseases such as Alzheimer’s and Parkinson’s.

“It is extremely difficult to get antibodies into the brain. Less than 5 percent of an injection of antibodies into a patient’s blood stream will enter the brain. Therefore, we need to make antibodies as potent as possible so the small fraction that does enter the brain will completely prevent formation of toxic protein particles linked to Alzheimer’s and Parkinson’s disease,” said Tessier, assistant professor in the Howard P. Isermann Department of Chemical and Biological Engineering at Rensselaer. “Our strategy for designing antibody inhibitors exploits the same molecular interactions that cause toxic particle formation, and the resulting antibodies are more potent inhibitors than antibodies generated by the immune system.”

Results of the new study, titled “Rational design of potent domain antibody inhibitors of amyloid fibril assembly,” were published online last week by the journal Proceedings of the National Academy of Sciences (PNAS).

Listen up, doc: Empathy raises patients’ pain tolerance

A doctor-patient relationship built on trust and empathy doesn’t just put patients at ease – it actually changes the brain’s response to stress and increases pain tolerance, according to new findings from a Michigan State University research team.

Medical researchers have shown in recent studies that doctors who listen carefully have happier patients with better health outcomes, but the underlying mechanism was unknown, said Issidoros Sarinopoulos, professor of radiology at MSU.

“This is the first study that has looked at the patient-centered relationship from a neurobiological point of view,” said Sarinopoulos, the lead researcher. “It’s important for doctors and others who advocate this type of relationship with the patient to show that there is a biological basis.”

Published in the journal Patient Education and Counseling, the study was part of a broader effort at MSU, led by professor of medicine Robert Smith, to establish standards for patient-centered health care and measure its effectiveness.

“Medicine has for too long focused just on the physical dimensions of the patient,” said Smith, who co-authored the paper. “Those clinical questions are important and necessary, but we’re trying to demonstrate that when you let patients tell their story in an unfettered way, you get more satisfied patients who end up healthier.”

Your Brain in Love

Men and women can now thank a dozen brain regions for their romantic fervor. Researchers have revealed the fonts of desire by comparing functional MRI studies of people who indicated they were experiencing passionate love, maternal love or unconditional love. Together, the regions release neuro­transmitters and other chemicals in the brain and blood that prompt greater euphoric sensations such as attraction and pleasure. Conversely, psychiatrists might someday help individuals who become dan­gerously depressed after a heartbreak by adjusting those chemicals.

Passion also heightens several cognitive functions, as the brain regions and chemicals surge. “It’s all about how that network interacts,” says Stephanie Ortigue, an assistant professor of psychology at Syracuse University, who led the study. The cognitive functions, in turn, “are triggers that fully activate the love network.”

(Graphics by James W. Lewis, West Virginia University (brain), and Jen Christiansen)

Human Evolution Enters an Exciting New Phase

“Most of the mutations that we found arose in the last 200 generations or so. There hasn’t been much time for random change or deterministic change through natural selection,” said geneticist Joshua Akey of the University of Washington, co-author of the Nov. 28 Nature study. “We have a repository of all this new variation for humanity to use as a substrate. In a way, we’re more evolvable now than at any time in our history.”

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Rhythmic Changes in Gene Activation Power the Circadian Clock

Rhythms underlie the daily functions of mammals, from sleep-wake cycles to metabolic processes in the liver. The circadian clock has evolved in response to daily changes in temperature and light in the environment. At the root of circadian rhythms are daily fluctuations in gene expression, which occur in part through the process of transcription—the creation of RNA from sequences of DNA. Although past studies have uncovered how changes in transcription states relate to irreversible processes, for example when cells become more specialized, much less is known about how transcription fluctuates in synch with recurring cycles.

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Alcoholic fly larvae need fix for learning

Fly larvae fed on alcohol-spiked food for a period of days grow dependent on those spirits for learning. The findings, reported in Current Biology, a Cell Press publication, on November 29th, show how overuse of alcohol can produce lasting changes in the brain, even after alcohol abuse stops.

The report also provides evidence that the very human experience of alcoholism can be explored in part with studies conducted in fruit flies and other animals, the researchers say.

"Our evidence supports the long-ago proposed idea that functional ethanol tolerance is produced by adaptations that counter the effects of ethanol, and that these adaptations help the nervous system function more normally when ethanol is present," says Brooks Robinson of The University of Texas at Austin. "However, when ethanol is withheld, the adaptations persist to give the nervous system abnormal properties that manifest themselves as symptoms of withdrawal."

Robinson and his colleagues found that alcohol consumption, at a level equivalent to mild intoxication in humans, at first impeded learning by fly larvae. More specifically, those larvae had some trouble in associating an unpleasant heat pulse with an otherwise attractive odor in comparison to larvae that had not been drinking alcohol.

After a six-day drinking binge, however, those larvae adapted and could learn as well as normal larvae could. In fact, the alcohol-adapted animals learned poorly when their ethanol was taken away from them. And, when given alcohol back, their learning deficit was erased.

Robinson says that the findings are the first proof of cognitive ethanol dependence in an invertebrate, suggesting that some of ethanol’s ability to change behavior must begin at the cellular level. After all, flies and humans share many of the same features at the level of individual neurons, and not so much in terms of the way those neurons are put together into working circuits.