Researchers Close In On The Most Important Question In Neuroscience With Fly Study

By scrutinizing the twists, turns, wiggles and squirms of 37,780 fruit fly larvae, neuroscientists have created an unprecedented view of how brain cells create behavior. The results, published March 27 in Science, draw direct connections between neurons and specific movements.

"Understanding how neural activity gives rise to behavior is the most important question in neuroscience," says neuroscientist Kay Tye of MIT, who was not involved in the research. The new study provides a way for scientists to start answering that question, she says. "I think this is a really important approach that ‘s going to be very influential."

Scientists led by Marta Zlatic of the Howard Hughes Medical Institute ‘s Janelia Farm Research Campus in Ashburn, Va., took advantage of an existing set of specially mutated flies. In each animal, small groups of neurons, usually between 2 and 15 cells, were engineered to respond to blue light. By activating handfuls of neurons with light and analyzing videos of the resulting behaviors, the researchers systematically explored most of the 10,000 neurons in Drosophila melanogaster larvae’s brain.

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Artificial intelligence lie detector

Wrongly accused and imprisoned for a crime you didn’t commit. It sounds like the plot to a generic crime thriller. However, this scenario does happen from time to time in the UK. From the Birmingham Six, falsely imprisoned for sixteen years, to the more recent case of Barri White, who was wrongly jailed for the murder of his girlfriend Rachel Manning, these situations can seem to the public like a tragic miscarriage of the criminal justice system.

However, what if you could stop these miscarriages of justice from happening? Imperial alumnus Dr James O’Shea, who graduated with a Bachelor of Science in Chemistry in 1976, has built a lie detector device called the ‘Silent Talker’ that he believes could help to improve criminal investigations.

While lie detector tests of any sort are not currently admissible evidence in British courts, Dr O’Shea believes Silent Talker could be an invaluable tool in helping law enforcement to focus their investigations.

Dr O’Shea says: “An original member of my team who helped to develop the Silent Talker was very close to the area where one of the attacks by Yorkshire Ripper took place. She took an interest in the case and found that the Ripper had been interviewed and passed over several times by the police. If the police had Silent Talker back then, it may have helped them to determine that they needed to spend a little more time on this guy, and investigate his background more closely.”

Artificially intelligent

The Silent Talker consists of a digital video camera that is hooked up to a computer. It runs a series of programs called artificial neural networks. These are computational models that take their design from animals’ central nervous systems, acting like an autonomous ‘brain’ for the device.

The computer programming in the artificial brain is a type of artificial intelligence called machine learning. It enables Silent Talker to learn and recognise patterns in data so that it can constantly adapt and reprogram itself during an interview. This enables Silent Talker to build up an overall profile of the subject to identify when someone is lying or telling the truth.

But how does it know when someone is lying? The inventors of the device claim it’s written all over your face. The camera records the subject in an interview and the artificial brain identifies non-verbal ‘micro-gestures’ on people’s faces. These are unconscious responses that Silent Talker picks up on to determine if the interviewee is lying.

Examples of micro-gestures include signs of stress, mental strain and what psychologists call ‘duping delight’. This refers to the unconscious flash of a smile at the pleasure and thrill of getting away with telling a lie. Dr O’Shea says these ‘tells’ are extremely fine-grained and exceedingly difficult for the interviewee to have any control over.

Coming to an interview near you

Dr O’Shea says the uses for such a device are numerous.

“One can imagine a near-future scenario in which your prospective employers are wearing Google Glasses, where every micro-gesture that ‘leaks’ from your face is a response that flashes by their eyes as ‘true’ or ‘false’ in real-time.”

While it does use the latest in computational techniques, Dr O’Shea says Silent Talker is not infallible. In tests to classify the micro-gestures as deceptive or non-deceptive, the Silent Talker has achieved an accuracy rate of 87 per cent.

However, this has not stopped prospective clients from clamouring for the device. Dr O’Shea and his colleagues have already been approached by security services about whether Silent Talker could be used to determine if people approaching a military checkpoint could be suicide bombers so that they can be eliminated before blowing up their target. The team’s answer has been a loud and emphatic ‘no’.

“In an ethical sense, such decisions should not be taken by a machine,” says Dr O’Shea.

Facebook’s facial recognition software is now as accurate as the human brain, but what now?

Facebook’s facial recognition research project, DeepFace (yes really), is now very nearly as accurate as the human brain. DeepFace can look at two photos, and irrespective of lighting or angle, can say with 97.25% accuracy whether the photos contain the same face. Humans can perform the same task with 97.53% accuracy. DeepFace is currently just a research project, but in the future it will likely be used to help with facial recognition on the Facebook website. It would also be irresponsible if we didn’t mention the true power of facial recognition, which Facebook is surely investigating: Tracking your face across the entirety of the web, and in real life, as you move from shop to shop, producing some very lucrative behavioral tracking data indeed.

The DeepFace software, developed by the Facebook AI research group in Menlo Park, California, is underpinned by an advanced deep learning neural network. A neural network, as you may already know, is a piece of software that simulates a (very basic) approximation of how real neurons work. Deep learning is one of many methods of performing machine learning; basically, it looks at a huge body of data (for example, human faces) and tries to develop a high-level abstraction (of a human face) by looking for recurring patterns (cheeks, eyebrow, etc). In this case, DeepFace consists of a bunch of neurons nine layers deep, and then a learning process that sees the creation of 120 million connections (synapses) between those neurons, based on a corpus of four million photos of faces.

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(Figure 1: Fluorescent labeling reveals mossy fibers (red) projecting from the dentate gyrus (green) into the CA2 subregion (orange). Credit: Keigo Kohara, RIKEN–MIT Center for Neural Circuit Genetics)

Novel combination of techniques reveals new details about the neuronal networks for memory

Learning and memory are believed to occur as a result of the strengthening of synaptic connections among neurons in a brain structure called the hippocampus. The hippocampus consists of five subregions, and a circuit formed between four of these is thought to be particularly important for memory formation. Keigo Kohara and colleagues from the RIKEN–MIT Center for Neural Circuit Genetics and RIKEN BioResource Center have now identified a previously unknown circuit involving the fifth subregion.

For a hundred years, memory research has typically focused on the main circuit, which projects from layer II of the entorhinal cortex via the dentate gyrus to subregion CA3 and then CA1. Subregion CA2 lies between CA3 and CA1 but its cells are less elaborate than those of its neighbors and were thought not to receive inputs from the dentate gyrus.

Kohara and his colleagues combined anatomical, genetic and physiological techniques to analyze the connections formed by neurons in the CA2 subregion of the hippocampus in unprecedented detail. First, they identified the CA2 subregion by examining the expression of three genes that encode proteins called RGS14, PCP4 and STEP using a fluorescent marker to label nerve fibers—a technique called fluorescent immunohistochemistry. They were surprised to discover that, contrary to expectations, CA2 neurons receive extensive inputs from cells in the dentate gyrus (Fig.1).

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Researchers demonstrate information processing using a light-based chip inspired by our brain

In a recent paper in Nature Communications, researchers from Ghent University report on a novel paradigm to do optical information processing on a chip, using techniques inspired by the way our brain works.

Neural networks have been employed in the past to solve pattern recognition problems like speech recognition or image recognition, but so far, these bio-inspired techniques have been implemented mostly in software on a traditional computer. What UGent researchers have done is implemented a small (16 nodes) neural network directly in hardware, using a silicon photonics chip. Such a chip is fabricated using the same technology as traditional computer chips, but uses light rather than electricity as the information carrier. This approach has many benefits including the potential for extremely high speeds and low power consumption.

The UGent researchers have experimentally shown that the same chip can be used for a large variety of tasks, like arbitrary calculations with memory on a bit stream or header recognition (an operation relevant in telecom networks: the header is an address indicating where the data needs to be sent). Additionally, simulations have shown that the same chip can perform a limited form of speech recognition, by recognising individual spoken digits (“one”, “two”, …).

A good trip: Researchers are giving psychedelics to cancer patients to help alleviate their despair — and it’s working

On a bone-chilling morning in February last year, Nick Fernandez bundled up and took the subway from his Manhattan apartment to the Bluestone Center for Clinical Research, which is located in an art deco-style building on the Upper East Side. A 27-year-old graduate student in psychology with dark, wavy hair and delicate, bird-like features, Fernandez was excited and nervous. He had eaten a light breakfast consisting of a bagel and industrial-strength coffee in preparation for another journey he was about to take. Fernandez had signed up to be a subject in a New York University study into the use of psilocybin, the psychoactive ingredient in hallucinogenic mushrooms, to relieve mental anguish in people with terminal or recurrent cancer.

Fernandez hoped that the drug would lift the shroud of melancholy and free-floating anxiety that had enveloped him ever since he was diagnosed with leukemia in 2004 during his senior year in high school. Two and a half years of almost continuous chemotherapy vanquished the disease, but left him drained and traumatised. The former soccer star dropped more than 50 lbs from an already lean frame. ‘It was pretty brutal and forces you to grow up fast,’ said Fernandez, who became intensely interested in spiritual philosophy during this period, and went on to dabble in psychedelics in college. For years afterward, every sneeze and sniffle, every day that he felt tired or out of sorts, filled him with an unshakeable dread that the cancer had returned. When he heard the study mentioned on a radio show, he immediately signed up.

Jeffrey Guss and Erin Zerbo, the two NYU psychiatrists who would quietly monitor Fernandez’s progress throughout the day, greeted him when he arrived. After they took his vital signs, Fernandez changed into sweat pants and a shirt, and settled into a converted dental exam room that had been transformed into a hippie-style sanctum: tricked out with fresh flowers and fruits, a comfy sofa littered with plush pillows, Buddhist and shamanistic totems, and a high-tech sound system. Stephen Ross, an associate professor of psychiatry at NYU and the lead investigator for the study, made a brief appearance in the trip room. He was holding a glass vial that had been retrieved earlier that morning from a massive safe located inside a high-security storage room. It contained a single white capsule, and no one could be sure if it was a placebo – a dummy pill – or a 30 milligram dose of synthesised psilocybin.

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Vast gene-expression map yields neurological and environmental stress insights

A consortium led by scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) has conducted the largest survey yet of how information encoded in an animal genome is processed in different organs, stages of development, and environmental conditions. Their findings paint a new picture of how genes function in the nervous system and in response to environmental stress.

They report their research this week in the Advance Online Publication of the journal Nature.

The scientists studied the fruit fly, an important model organism in genetics research. Seventy percent of known human disease genes have closely related genes in the fly, yet the fly genome is one-thirtieth the size of ours. Previous fruit fly research has provided insights on cancer, birth defects, addictive behavior, and neurological diseases. It has also advanced our understanding of processes common to all animals such as body patterning and synaptic transmission.

In the latest scientific fruit from the fruit fly, the consortium, led by Susan Celniker of Berkeley Lab’s Life Sciences Division, generated the most comprehensive map of gene expression in any animal to date. Scientists from the University of California at Berkeley, Indiana University at Bloomington, the University of Connecticut Health Center, and several other institutions contributed to the research.

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Physics-minded crows bring Aesop’s fable to life

Eureka! Like Archimedes in his bath, crows know how to displace water, showing that Aesop’s fable The Crow and the Pitcher isn’t purely fictional.

To see if New Caledonian crows could handle some of the basic principles of volume displacement, Sarah Jelbert at the University of Auckland in New Zealand and her colleagues placed scraps of meat just out of a crow’s reach, floating in a series of tubes that were part-filled with water. Objects potentially useful for bringing up the water level, like stones or heavy rubber erasers, were left nearby.

The crows successfully figured out that heavy and solid objects would help them get a treat faster. They also preferred to drop objects in tubes where they could access a reward more easily, picking out tubes with higher water levels and choosing tubes of water over sand-filled ones.

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