Neuroscience

Articles and news from the latest research reports.

Posts tagged neuroscience

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Soon, space robots like Curiosity may evolve even greater intelligence
After more than eight years of planning and a 254-day journey through the cold emptiness of space, NASA’s Curiosity rover has finally landed on Mars.  Curiosity is the most advanced mobile robotic science lab to ever explore another planet and thus this is an exciting moment for NASA and the world.
But robotics and artificial intelligence continue to advance at an exponential rate. As we look towards the future of space exploration in the next decade and beyond, we can expect the next generation of space robots to be orders of magnitude more powerful and intelligent, while at the same time costing a fraction of Curiosity’s $2.5 billion price tag.

Soon, space robots like Curiosity may evolve even greater intelligence

After more than eight years of planning and a 254-day journey through the cold emptiness of space, NASA’s Curiosity rover has finally landed on Mars.  Curiosity is the most advanced mobile robotic science lab to ever explore another planet and thus this is an exciting moment for NASA and the world.

But robotics and artificial intelligence continue to advance at an exponential rate. As we look towards the future of space exploration in the next decade and beyond, we can expect the next generation of space robots to be orders of magnitude more powerful and intelligent, while at the same time costing a fraction of Curiosity’s $2.5 billion price tag.

Filed under AI curiosity intelligence neuroscience robotics science space computer science technology

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The brains of people with schizophrenia may attempt to heal from the disease

7 August 2012

New NeuRA research shows that the brains of people with schizophrenia may attempt to repair damage caused by the disease, in another example of the adult brain’s capacity to change and grow.

Prof Cyndi Shannon Weickert, Dr Dipesh Joshi and colleagues from Neuroscience Research Australia studied the brains of people with schizophrenia and focussed on one of the hardest-hit regions, the orbitofrontal cortex, which is the part of the brain involved in regulating emotional and social behaviour.

Most neurons – brain cells that transmit information – are found in tissue near the surface of the brain. However, in the brains of people with schizophrenia, the team found a high density of neurons in deeper areas.

“For over a decade we’ve known about the high density of neurons in deeper brain tissue in people with schizophrenia. Researchers thought these neurons were simply forgotten by the brain, and somehow didn’t die off like they do during development in healthy people,” says Prof Shannon Weickert.

“What we now have is evidence that suggests these neurons are derived from the part of the brain that produces new neurons, and that they may be in the process of moving. We can’t be sure where they are moving to, but given their location it is likely they are on their way to the surface of the brain, the area most affected by schizophrenia,” Prof Shannon Weickert concluded.

How was this study done?
  • Brain tissue from the orbitofrontal cortex from 38 people with schizophrenia and 38 people without the disease were used in this study.
  • The density of interstitial neurons in the white matter, and the density of GABAergic neurons in the grey matter were measured.
  • An increased density of interstitial white matter neurons in the white matter, and decreased density of GABAergic neurons in the grey matter was found.
  • This pattern suggests that the migration of interstitial white matter neurons towards an area where they are lacking, because of schizophrenia, is a response to the disease.
Source: Neuroscience Research Australia

Filed under science neuroscience brain psychology schizophrenia research orbitofrontal cortex neuron

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The Algorithm That Finds Connections Scientists Never See
Here’s a thought experiment for you: 
If someone told you you had to drink just one kind of alcoholic beverage for the rest of your life, and you wanted that life to be long and healthy, what would you pick? Wine, right? After all, you’ve probably heard about the scientific studies showing that drinking wine is associated with better health in general, and a longer life span in particular. Give jocks their beer and lushes their hard liquor; the drink of robust, long-lived people is wine.
But you have probably not heard about another study, released during the media dead zone just after Christmas last year, that questioned wine’s reputed health effects. Researchers at Stanford University and the University of Texas at Austin examined a group of Americans aged 55 to 65 and compared their drinking habits with how they fared over the course of 20 years. The scientists found that moderate drinkers lived longer than abstainers, and that wine drinkers did indeed live longer on average than people who consumed other kinds of alcohol. But they also found that wine drinkers were less likely to smoke, to be male, and to be sedentary; all of these are factors associated with dying earlier.
The Stanford-Texas team concluded that drinking wine might be an indicator of a healthy lifestyle rather than the cause of that good health. If so, wine is the drink of the healthy, all right—the already healthy.
That finding highlights what is arguably science’s greatest enemy, the confounder. Science is at heart a reductionist process: Take a complicated system, identify various factors that affect the system, and measure the effect of each factor one at a time. Confounders are devilish hidden connections that make it more difficult to isolate the factors you want to measure, like the fact that wine drinkers tend also to be nonsmokers…

The Algorithm That Finds Connections Scientists Never See

Here’s a thought experiment for you: 
If someone told you you had to drink just one kind of alcoholic beverage for the rest of your life, and you wanted that life to be long and healthy, what would you pick? Wine, right? After all, you’ve probably heard about the scientific studies showing that drinking wine is associated with better health in general, and a longer life span in particular. Give jocks their beer and lushes their hard liquor; the drink of robust, long-lived people is wine.

But you have probably not heard about another study, released during the media dead zone just after Christmas last year, that questioned wine’s reputed health effects. Researchers at Stanford University and the University of Texas at Austin examined a group of Americans aged 55 to 65 and compared their drinking habits with how they fared over the course of 20 years. The scientists found that moderate drinkers lived longer than abstainers, and that wine drinkers did indeed live longer on average than people who consumed other kinds of alcohol. But they also found that wine drinkers were less likely to smoke, to be male, and to be sedentary; all of these are factors associated with dying earlier.

The Stanford-Texas team concluded that drinking wine might be an indicator of a healthy lifestyle rather than the cause of that good health. If so, wine is the drink of the healthy, all right—the already healthy.

That finding highlights what is arguably science’s greatest enemy, the confounder. Science is at heart a reductionist process: Take a complicated system, identify various factors that affect the system, and measure the effect of each factor one at a time. Confounders are devilish hidden connections that make it more difficult to isolate the factors you want to measure, like the fact that wine drinkers tend also to be nonsmokers…

Filed under neuroscience psychology research science confounding variable

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Epileptic Fits Are Like Raging Thunderstorms: Astrocytes Help Reduce Long-Term Damage, Surprising New Research Shows
In the journal Experimental Neurology, the scientists report the beneficial effects of so-called astrocytes, a certain type of glial cells. They get their name from the Greek word for glue, as it was long thought that these cells simply hold the nerve cells together and provided them with nutrients. In the case of epilepsy, the prevalent opinion was that their reaction to a seizure would actually damage the brain. The researchers from Freiburg disagree. In fact, they say, astrocytes help to reduce long-term damage brought upon by epileptic fits.The team discovered the positive effects of astrocytes in mice, in which epileptic states can be selectively triggered. If the scientists injected mice with a specific protein to activate the astrocytes prior to an epilepsy-inducing insult, fewer nerve cells died in the wake of the seizure. Other pathological changes that would usually occur in the brain were likewise significantly reduced. The astrocytes’ protective effect lasted for many days after their activation. When the researchers measured the rodents’ brain activity, they likewise found fewer signs that are typical for a brain suffering from epilepsy. However, the authors report that the astrocytes had to be already activated before seizures were elicited. Activating them afterwards, on the other hand, did not lead to a protective effect.Further studies will have to demonstrate that astrocytes have this protective influence all over the brain. According to Haas, who is also a member of Freiburg’s new cluster of excellence BrainLinks-BrainTools, their findings suggest that a timely activation of astrocytes could offer an effective protection from long-term damage to the brain.

Epileptic Fits Are Like Raging Thunderstorms: Astrocytes Help Reduce Long-Term Damage, Surprising New Research Shows

In the journal Experimental Neurology, the scientists report the beneficial effects of so-called astrocytes, a certain type of glial cells. They get their name from the Greek word for glue, as it was long thought that these cells simply hold the nerve cells together and provided them with nutrients. In the case of epilepsy, the prevalent opinion was that their reaction to a seizure would actually damage the brain. The researchers from Freiburg disagree. In fact, they say, astrocytes help to reduce long-term damage brought upon by epileptic fits.

The team discovered the positive effects of astrocytes in mice, in which epileptic states can be selectively triggered. If the scientists injected mice with a specific protein to activate the astrocytes prior to an epilepsy-inducing insult, fewer nerve cells died in the wake of the seizure. Other pathological changes that would usually occur in the brain were likewise significantly reduced. The astrocytes’ protective effect lasted for many days after their activation. When the researchers measured the rodents’ brain activity, they likewise found fewer signs that are typical for a brain suffering from epilepsy. However, the authors report that the astrocytes had to be already activated before seizures were elicited. Activating them afterwards, on the other hand, did not lead to a protective effect.

Further studies will have to demonstrate that astrocytes have this protective influence all over the brain. According to Haas, who is also a member of Freiburg’s new cluster of excellence BrainLinks-BrainTools, their findings suggest that a timely activation of astrocytes could offer an effective protection from long-term damage to the brain.

Filed under science neuroscience brain psychology astrocytes epilepsy research

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Having an operation?Don’t be surprised if the surgeon performs it from the room next door.Indeed, he could even operate from halfway across the world — because these doctors are increasingly using robots to treat disease and injury.‘These are incredibly exciting times,’ says Brian Davies, emeritus professor of medical robotics at Imperial College London and inventor of the surgical robot, which in April 1991 became the first in the world to remove tissue from a living human.‘Robots can work much more accurately than human hands, which is fantastic now that we are seeking minimally invasive surgery through a tiny incision where precision is key,’ says Professor Davies.Of course, the surgeon still performs the operation, but uses the robot to see inside the body, or operates it using a joystick or console so it’s like a spare arm — but without the human hand’s natural shake.‘Medical robots are not like the sci-fi images of autonomous humanoids; they are sophisticated computer-assisted instruments that remain always under the surgeon’s control,’ says Dr Patrick Finlay, founder of medical robotics firm MediMaton.

Read more: The rise of Robodoc: They can operate on everything from your heart to creaky knees - but would you put your life into the hands of a robot surgeon?

Having an operation?

Don’t be surprised if the surgeon performs it from the room next door.

Indeed, he could even operate from halfway across the world — because these doctors are increasingly using robots to treat disease and injury.

‘These are incredibly exciting times,’ says Brian Davies, emeritus professor of medical robotics at Imperial College London and inventor of the surgical robot, which in April 1991 became the first in the world to remove tissue from a living human.

‘Robots can work much more accurately than human hands, which is fantastic now that we are seeking minimally invasive surgery through a tiny incision where precision is key,’ says Professor Davies.

Of course, the surgeon still performs the operation, but uses the robot to see inside the body, or operates it using a joystick or console so it’s like a spare arm — but without the human hand’s natural shake.

‘Medical robots are not like the sci-fi images of autonomous humanoids; they are sophisticated computer-assisted instruments that remain always under the surgeon’s control,’ says Dr Patrick Finlay, founder of medical robotics firm MediMaton.

Read more: The rise of Robodoc: They can operate on everything from your heart to creaky knees - but would you put your life into the hands of a robot surgeon?

Filed under brain health medical robots neuroscience robotics science surgery disease injury

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Social Network Size Linked to Brain Size
As humans, we aren’t born with formidable armaments or defenses, nor are we the strongest, fastest, or biggest species, yet despite this we are amazingly successful. For a long time it was thought that this success was because our enlarged brains allows each of us to be smarter than our competitors: better at abstract thinking, better with tools and better at adapting our behavior to those of our prey and predators. But are these really the most significant skills our brains provide us with?
Another possibility is that we are successful because we can form long-lasting relationships with many others in diverse and flexible ways, and that this, combined with our native intelligence, explains why homo sapiens came to dominate the planet. In every way from teaching our young to the industrial division of labour we are a massively co-operative species that relies on larger and more diverse networks of relationships than any other species.

Social Network Size Linked to Brain Size

As humans, we aren’t born with formidable armaments or defenses, nor are we the strongest, fastest, or biggest species, yet despite this we are amazingly successful. For a long time it was thought that this success was because our enlarged brains allows each of us to be smarter than our competitors: better at abstract thinking, better with tools and better at adapting our behavior to those of our prey and predators. But are these really the most significant skills our brains provide us with?

Another possibility is that we are successful because we can form long-lasting relationships with many others in diverse and flexible ways, and that this, combined with our native intelligence, explains why homo sapiens came to dominate the planet. In every way from teaching our young to the industrial division of labour we are a massively co-operative species that relies on larger and more diverse networks of relationships than any other species.

Filed under brain neuroscience psychology relationships science social network cognition

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How digital culture is rewiring our brains
Our brains are superlatively evolved to adapt to our environment: a process known as neuroplasticity. The connections between our brain cells will be shaped, strengthened and refined by our individual experiences. It is this personalisation of the physical brain, driven by unique interactions with the external world, that arguably constitutes the biological basis of each mind, so what will happen to that mind if the external world changes in unprecedented ways, for example, with an all-pervasive digital technology?
A recent survey in the US showed that more than half of teenagers aged 13 to 17 spend more than 30 hours a week, outside school, using computers and other web-connected devices. If their environment is being transformed for so much of the time into a fast-paced and highly interactive two-dimensional space, the brain will adapt, for good or ill. Professor Michael Merzenich, of the University of California, San Francisco, gives a typical neuroscientific perspective.
”There is a massive and unprecedented difference in how [digital natives’] brains are plastically engaged in life compared with those of average individuals from earlier generations and there is little question that the operational characteristics of the average modern brain substantially differ,” he says.

How digital culture is rewiring our brains

Our brains are superlatively evolved to adapt to our environment: a process known as neuroplasticity. The connections between our brain cells will be shaped, strengthened and refined by our individual experiences. It is this personalisation of the physical brain, driven by unique interactions with the external world, that arguably constitutes the biological basis of each mind, so what will happen to that mind if the external world changes in unprecedented ways, for example, with an all-pervasive digital technology?

A recent survey in the US showed that more than half of teenagers aged 13 to 17 spend more than 30 hours a week, outside school, using computers and other web-connected devices. If their environment is being transformed for so much of the time into a fast-paced and highly interactive two-dimensional space, the brain will adapt, for good or ill. Professor Michael Merzenich, of the University of California, San Francisco, gives a typical neuroscientific perspective.

”There is a massive and unprecedented difference in how [digital natives’] brains are plastically engaged in life compared with those of average individuals from earlier generations and there is little question that the operational characteristics of the average modern brain substantially differ,” he says.

Filed under adaptation brain neuroplasticity neuroscience psychology science technology cyber environment

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Cannabis as Painkiller
Cannabis-based medications have been proved to relieve pain. This is the conclusion drawn by Franjo Grotenhermen and Kirsten Müller-Vahl in issue 29–30 of Deutsches Ärzteblatt International.
Cannabis medications can be used in patients whose symptoms are not adequately alleviated by conventional treatment. The indications are muscle spasms, nausea and vomiting as a result of chemotherapy, loss of appetite in HIV/Aids, and neuropathic pain.
The clinical effect of the various cannabis-based medications rests primarily on activation of endogenous cannabinoid receptors. Consumption of therapeutic amounts by adults does not lead to irreversible cognitive impairment. The risk is much greater, however, in children and adolescents (particularly before puberty), even at therapeutic doses.
Over 100 controlled trials of the effects of cannabinoids in various indications have been carried out since 1975. The positive results have led to official licensing of cannabis-based medications in many countries. In Germany, a cannabis extract was approved in 2011 for treatment of spasticity in multiple sclerosis. In June 2012 the Federal Joint Committee (the highest decision-making body for the joint self-government of physicians, dentists, hospitals and health insurance funds in Germany) pronounced that the cannabis extract showed a slight additional benefit for this indication and granted a temporary license until 2015.

Cannabis as Painkiller

Cannabis-based medications have been proved to relieve pain. This is the conclusion drawn by Franjo Grotenhermen and Kirsten Müller-Vahl in issue 29–30 of Deutsches Ärzteblatt International.

Cannabis medications can be used in patients whose symptoms are not adequately alleviated by conventional treatment. The indications are muscle spasms, nausea and vomiting as a result of chemotherapy, loss of appetite in HIV/Aids, and neuropathic pain.

The clinical effect of the various cannabis-based medications rests primarily on activation of endogenous cannabinoid receptors. Consumption of therapeutic amounts by adults does not lead to irreversible cognitive impairment. The risk is much greater, however, in children and adolescents (particularly before puberty), even at therapeutic doses.

Over 100 controlled trials of the effects of cannabinoids in various indications have been carried out since 1975. The positive results have led to official licensing of cannabis-based medications in many countries. In Germany, a cannabis extract was approved in 2011 for treatment of spasticity in multiple sclerosis. In June 2012 the Federal Joint Committee (the highest decision-making body for the joint self-government of physicians, dentists, hospitals and health insurance funds in Germany) pronounced that the cannabis extract showed a slight additional benefit for this indication and granted a temporary license until 2015.

Filed under brain cannabis neuroscience pain psychology research science medication

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Study uses stem cells to boost red blood cell production

August 7, 2012

(HealthDay) — Using human stem cells, scientists have developed methods to boost the production of red blood cells, according to a new study.

Their discovery could significantly increase the blood supply needed for blood transfusions, the researchers said, and their methods can be used to produce any blood type.

"Being able to produce red blood cells from stem cells has the potential to overcome many difficulties of the current system, including sporadic shortages," Dr. Anthony Atala, editor of the journal Stem Cells Translational Medicine, in which the study appeared, said in a journal news release.

"This team has made a significant contribution to scientists’ quest to produce red blood cells in the lab," said Atala, who is also director of the Wake Forest Institute for Regenerative Medicine.

How does the new process work?

"We combined different cell-expansion protocols into a ‘cocktail’ that increased the number of cells we could produce by 10- to 100-fold," said researcher Eric Bouhassira, of the Albert Einstein College of Medicine in New York City.

Currently, the blood needed for life-saving transfusions is obtained only through donations. As a result, blood can be in short supply, particularly for those with rare blood types. The researchers produced a higher yield of red blood cells by using stem cells from cord blood and circulating blood as well as embryonic stem cells, according to the release.

"The ability of scientists to grow large quantities of red blood cells at an industrial scale could revolutionize the field of transfusion medicine," Bouhassira said. "Collecting blood through a donation-based system is serving us well but it is expensive, vulnerable to disruption and insufficient to meet the needs of some people who need ongoing transfusions. This could be a viable long-term alternative."

Source: medicalxpress.com

Filed under science neuroscience brain psychology blood cells stem cells

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Staff at the Seattle Children’s hospital have created the Cat Immersion Project — an audiovisual installation that brought thousands of virtual cats to a teenage cancer patient’s room.

16-year-old cancer patient Maga Barzallo Sockemtickem had spent seven months in the hospital in 2011 and had to return for more treatment in July this year. Because of her compromised immune system, she had to be isolated and was unable to see her beloved cat Merry.

Filed under animals hospital neuroscience psychology science tech projection

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