Posts tagged memory
Articles and news from the latest research reports.
The genetic code of the fruit fly Drosophila has been hacked into, allowing it to make proteins with properties that don’t exist in the natural world. The advance could ultimately lead to the creation of new or “improved” life forms in the burgeoning field of synthetic biology.
The four letters of the genetic code, A, C, T and G, are read in triplets, called codons, by the cell’s protein-making machinery. Each codon gives an instruction for the type of amino acid that gets added next in a protein chain, or tells the machinery to stop.
Complex proposition
As a proof of principle, Chin’s team has engineered fruit flies that incorporated three new amino acids into proteins in the cells of their ovaries.
The flies were engineered using bacteria that had been modified to insert the genetic code for the unnatural amino acid into the fly DNA. There was no apparent impact on the flies’ health, and they even produced healthy offspring that also made the new protein chains.
Bulletproof flies
None of the amino acids were particularly remarkable, but the fact that engineering the flies had no obvious impact on their health suggests that many more useful amino acids could be similarly incorporated.
For example, work in bacterial cells has shown that it is possible to incorporate unnatural amino acids that cross-link to each other or turn an enzyme’s activity on or off when a light is shone on them. Doing this in a complex organism like a fly could shed new light on how proteins interact within cells, or how rapidly turning an enzyme on or off affects the cell’s function.
The technique could even be used to create animals with new or improved properties, although that is probably some years off.
Sheep Brain Dissection: The Anatomy of Memory
By dissecting the brain of a sheep -an animal in which brain structure and function are similar to our own- we can see where memory processes take place. Throughout our lives, our memories are constantly being formulated, accessed, and filtered by the brain. Fleeting electrochemical connections made between brain cells help us remember the thoughts, skills, experiences and knowledge that make each of us unique.
Mother loses 20 years of memory after fall
Kay Delaney, 55, slipped over at work and hit her head last year, suffering a minor traumatic brain injury which caused retrograde amnesia.
She is now convinced she is 34 years old, with her last memory being putting her young son and daughter to bed in the early 1990s.
Former home manager Kay said she is surprised every time she looks in the mirror at her aged face, and has no concept of the last two decades.
Saying she feels an “almost unbearable” sense of guilt after failing to remember the birth of her youngest son, now 20, she added she “cannot even begin to describe the pain and sense of loss” at being left “without a sense of motherhood”.
Mother-of-three Kay struggles to recognise mobile phones and computers, or even make a cup of tea because she repeatedly forgets to boil the kettle.
The World’s Most Famous Brain
In the summer of 1953, Henry Gustav Molaison (1926-2008) underwent brain surgery to contain epileptic seizures that had become critically debilitating. The intervention brought some relief from convulsions, but these positive results were overshadowed by an astonishing and indelible side effect. Soon after the operation, it became apparent that he could no longer recognize hospital staff, he did not remember the way home, he did not remember newspaper articles he had just read, nor the crossword puzzles he had solved; otherwise, he was completely normal. Since the time of the surgery, more than five decades of scrupulous neuropsychological research examined the nature of patient H.M.’s amnesia which proved to be both persistent and remarkably selective.
The goal of our project is to provide a window into the brain of the man who helped establish the scientific study of memory and unfailingly forgot the enormously generous contribution he made to medical research.
Musicians’ Brains Might Have an Edge on Aging
It’s been said that music soothes the savage beast, but if you’re the one playing the instrument it might benefit your brain.
A growing body of evidence suggests that learning to play an instrument and continuing to practice and play it may offer mental benefits throughout life. Hearing has also been shown to be positively affected by making music.
When We Forget to Remember: Failures in Prospective Memory Range from Annoying to Lethal
A surgical team closes an abdominal incision, successfully completing a difficult operation. Weeks later, the patient comes into the ER complaining of abdominal pain and an X-ray reveals that one of the forceps used in the operation was left inside the patient. Why would highly skilled professionals forget to perform a simple task they have executed without difficulty thousands of times before?
These kinds of oversights occur in professions as diverse as aviation and computer programming, but research from psychological science reveals that these lapses may not reflect carelessness or lack of skill but failures of prospective memory.
Failures of prospective memory typically occur when we form an intention to do something later, become engaged with various other tasks, and lose focus on the thing we originally intended to do. Despite the name, prospective memory actually depends on several cognitive processes, including planning, attention, and task management. Common in everyday life, these memory lapses are mostly annoying, but can have tragic consequences.
Brains are different in people with highly superior autobiographical memory
July 30, 2012
UC Irvine scientists have discovered intriguing differences in the brains and mental processes of an extraordinary group of people who can effortlessly recall every moment of their lives since about age 10.
The phenomenon of highly superior autobiographical memory – first documented in 2006 by UCI neurobiologist James McGaugh and colleagues in a woman identified as “AJ” – has been profiled on CBS’s “60 Minutes” and in hundreds of other media outlets. But a new paper in the peer-reviewed journal Neurobiology of Learning & Memory’s July issue offers the first scientific findings about nearly a dozen people with this uncanny ability.
All had variations in nine structures of their brains compared to those of control subjects, including more robust white matter linking the middle and front parts. Most of the differences were in areas known to be linked to autobiographical memory, “so we’re getting a descriptive, coherent story of what’s going on,” said lead author Aurora LePort, a doctoral candidate at UCI’s Center for the Neurobiology of Learning & Memory.
Surprisingly, the people with stellar autobiographical memory did not score higher on routine laboratory memory tests or when asked to use rote memory aids. Yet when it came to public or private events that occurred after age 10½, “they were remarkably better at recalling the details of their lives,” said McGaugh, senior author on the new work.
"These are not memory experts across the board. They’re 180 degrees different from the usual memory champions who can memorize pi to a large degree or other long strings of numbers," LePort noted. "It makes the project that much more interesting; it really shows we are homing in on a specific form of memory."
She said interviewing the subjects was “baffling. You give them a date, and their response is immediate. The day of the week just comes out of their minds; they don’t even think about it. They can do this for so many dates, and they’re 99 percent accurate. It never gets old.”
The study also found statistically significant evidence of obsessive-compulsive tendencies among the group, but the authors do not yet know if or how this aids recollection. Many of the individuals have large, minutely catalogued collections of some sort, such as magazines, videos, shoes, stamps or postcards.
UCI researchers and staff have assessed more than 500 people who thought they might possess highly superior autobiographical memory and have confirmed 33 to date, including the 11 in the paper. Another 37 are strong candidates who will be further tested.
"The next step is that we want to understand the mechanisms behind the memory," LePort said. "Is it just the brain and the way its different structures are communicating? Maybe it’s genetic; maybe it’s molecular."
McGaugh added: “We’re Sherlock Holmeses here. We’re searching for clues in a very new area of research.”
Provided by University of California, Irvine
Source: medicalxpress.com
Science of Eyewitness Memory Enters Courtroom
Science has prevailed over injustice in the state of New Jersey, where all jurors will soon learn about memory’s unreliability and the limits of eyewitness testimony.
According to instructions issued July 19 by New Jersey’s Supreme Court, judges must tell jurors that “human memory is not foolproof,” and enumerate the many ways in which eyewitness recall can be distorted or mistaken.
The longer you’re awake, the slower you get
July 27, 2012
Anyone that has ever had trouble sleeping can attest to the difficulties at work the following day. Experts recommend eight hours of sleep per night for ideal health and productivity, but what if five to six hours of sleep is your norm? Is your work still negatively affected? A team of researchers at Brigham and Women’s Hospital (BWH) have discovered that regardless of how tired you perceive yourself to be, that lack of sleep can influence the way you perform certain tasks.
This finding is published in the July 26, 2012 online edition of The Journal of Vision.
"Our team decided to look at how sleep might affect complex visual search tasks, because they are common in safety-sensitive activities, such as air-traffic control, baggage screening, and monitoring power plant operations," explained Jeanne F. Duffy, PhD, MBA, senior author on this study and associate neuroscientist at BWH. "These types of jobs involve processes that require repeated, quick memory encoding and retrieval of visual information, in combination with decision making about the information."
Researchers collected and analyzed data from visual search tasks from 12 participants over a one month study. In the first week, all participants were scheduled to sleep 10-12 hours per night to make sure they were well-rested. For the following three weeks, the participants were scheduled to sleep the equivalent of 5.6 hours per night, and also had their sleep times scheduled on a 28-hour cycle, mirroring chronic jet lag. The research team gave the participants computer tests that involved visual search tasks and recorded how quickly the participants could find important information, and also how accurate they were in identifying it. The researchers report that the longer the participants were awake, the more slowly they identified the important information in the test. Additionally, during the biological night time, 12 a.m. -6 a.m., participants (who were unaware of the time throughout the study) also performed the tasks more slowly than they did during the daytime.
"This research provides valuable information for workers, and their employers, who perform these types of visual search tasks during the night shift, because they will do it much more slowly than when they are working during the day," said Duffy. "The longer someone is awake, the more the ability to perform a task, in this case a visual search, is hindered, and this impact of being awake is even stronger at night."
While the accuracy of the participants stayed the fairly constant, they were slower to identify the relevant information as the weeks went on. The self-ratings of sleepiness only got slightly worse during the second and third weeks on the study schedule, yet the data show that they were performing the visual search tasks significantly slower than in the first week. This finding suggests that someone’s perceptions of how tired they are do not always match their performance ability, explains Duffy.
Provided by Brigham and Women’s Hospital
Source: medicalxpress.com
Piglets substitute for human babies in cognitive science maze test
A team from the Beckman Institute at the University of Illinois is using piglets instead of human babies to try and model the cognitive development of infants.
Human infants cannot be used as laboratory subjects. The idea to use piglets came when one of neuroscientist Rodney Johnson’s former students, who was working for an infant formula company, asked him about finding ways to monitor the differences in cognitive development between breast-fed and formula-fed children.
As a result he and his colleague Ryan Dilger became interested in using the neonatal piglet as a model for human brain development. The growth and development of the piglet brain is similar to that of the human brain — at birth the human brain is 25 percent of adult size. In the first two years of life, it reaches 85 to 90 percent of adult size. The piglet brain grows in a similar way in a shorter time.
They wanted to see whether they could develop tests to look at learning and memory development using these pigs. First of all they developed MRI techniques to quantify the size of the brain, taking measurements at regular intervals.
They then developed a test using a maze to assess piglets’ learning and memory. This turned out to be much more complicated than expected. Johnson said: “When we first started these studies, we used things like Skittles and apple slices as a reward because that’s what people using older pigs had done.”
However, the piglets were used to being fed on infant formula and so had no interest in solid food, nor were they motivated to perform tasks if the reward was the same as their regular food. The solution was to use Nesquik chocolate milk as a reward.
Tests took place in a plus-sign-shaped maze with one arm blocked off to leave a T shape. Piglets were trained to locate the milk reward using visual cues from outside the maze. When they learned how to do this and the reward location was moved, and the pigs were retested to assess learning and working memory.
Having established that the tests can be used to measure cognitive abilities, the team will examine how nutrient deficiencies (such as iron) and infections (such as pneumonia) affect the human brain during this time of early brain growth.
Johnson said: “There is a lot of interest in the concept of programming, the notion that things that occur early in life set that individual up for problems that occur many years later. Because the pig brain grows so much like a human brain, we thought this could be a very attractive model.”
In order to measure changes in the brain they look at neuroinflammation, neuron growth and changes, as well as biochemical in the brain.
The team hopes to receive funding to look at maternal viral infections, where pregnant pigs will be infected with diseases to see how it affects the brain development of their offspring.