Neuroscience

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Yogic breathing shows promise in reducing symptoms of post-traumatic stress disorder

One of the greatest casualties of war is its lasting effect on the minds of soldiers. This presents a daunting public health problem: More than 20 percent of veterans returning from the wars in Iraq and Afghanistan have post-traumatic stress disorder, according to a 2012 report by RAND Corp.

A new study from the Center for Investigating Healthy Minds at the Waisman Center of the University of Wisconsin-Madison offers hope for those suffering from the disorder. Researchers there have shown that a breathing-based meditation practice called Sudarshan Kriya Yoga can be an effective treatment for PTSD.

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Individuals with PTSD suffer from intrusive memories, heightened anxiety, and personality changes. The hallmark of the disorder is hyperarousal, which can be defined as overreacting to innocuous stimuli, and is often described as feeling “jumpy,” or easily startled and constantly on guard.

Hyperarousal is one aspect of the autonomic nervous system, the system that controls the beating of the heart and other body functions, and governs one’s ability to respond to his or her environment. Scientists believe hyperarousal is at the core of PTSD and the driving force behind some of its symptoms.

Standard treatment interventions for PTSD offer mixed results. Some individuals are prescribed antidepressants and do well while others do not; others are treated with psychotherapy and still experience residual affects of the disorder.

Sudarshan Kriya Yoga is a practice of controlled breathing that directly affects the autonomic nervous system. While the practice has proven effective in balancing the autonomic nervous system and reducing symptoms of PTSD in tsunami survivors, it has not been well studied until now.

The CIHM team was interested in Sudarshan Yoga because of its focus on manipulating the breath, and how that in turn may have consequences for the autonomic nervous system and specifically, hyperarousal. Theirs is the first randomized, controlled, longitudinal study to show that the practice of controlled breathing can benefit people with PTSD.

"This was a preliminary attempt to begin to gather some information on whether this practice of yogic breathing actually reduces symptoms of PTSD," says Richard J. Davidson, founder of CIHM and one of the authors of the study. "Secondly, we wanted to find out whether the reduction in symptoms was associated with biological measures that may be important in hyperarousal."

These tests included measuring eye-blink startle magnitude and respiration rates in response to stimuli such as a noise burst in the laboratory. Respiration is one of the functions controlled by the autonomic nervous system; the eye-blink startle rate is an involuntary response that can be used to measure one component of hyperarousal. These two measurements reflect aspects of mental health because they affect how an individual regulates emotion.

The CIHM study included 21 soldiers: an active group of 11 and a control group of 10. Those who received the one-week training in yogic breathing showed lower anxiety, reduced respiration rates and fewer PTSD symptoms.

Davidson would like to further the research by including more participants, with the end goal of enabling physicians to prescribe treatment based on the cognitive and emotional style of the individual patient.

"A clinician could use a ‘tool box’ of psychological assessments to determine the cognitive and emotional style of the patient, and thereby determine a treatment that would be most effective for that individual," he says. "Right now, a large fraction of individuals who are given any one type of therapy are not improving on that therapy. The only way we can improve that is if we determine which kinds of people will benefit most from different types of treatments."

That assessment is critical. At least 22 veterans take their own lives every day, according to the U.S. Department of Veterans Affairs. Because Sudarshan Kriya Yoga has already been shown to increase optimism in college students, and reduce stress and anxiety in people suffering from depression, it may be an effective way to decrease suffering and, quite possibly, the incidence of suicide among veterans.

The study, published in the Journal of Traumatic Stress, was funded by a grant from the Disabled Veterans of America Charitable Service Trust and individual donors.

(Source: news.wisc.edu)

Filed under PTSD yogic breathing meditation psychology neuroscience science

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Yoga Relieves Multiple Sclerosis Symptoms

Paula Meltzer was only 38 when out of nowhere everything she looked at was blurry. For the single mother, who had a lucrative career as a gemologist and spent hours examining valuable pieces of jewelry, it seemed as if – in a split second – her life changed.

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At first doctors thought Meltzer had a brain tumor. What they determined after further tests, however, was that she had multiple sclerosis, an autoimmune disease that affects the brain and central nervous system and was causing optic neuritis, an inflammation of the optic nerve that can cause a partial or complete loss of vision.

“I was living independently, doing my job, taking care of my child – and then I had to look to my parents to take care of me,” Meltzer said.

Almost two decades later, Meltzer, out of a wheelchair and walking without a cane, was one of 14 women with moderate disability due to MS who participated in a pilot trial conducted by the Rutgers School of Health Related Professions. A specially-designed yoga program for these MS patients not only improved their physical and mental well-being but also enhanced their overall quality of life.

“I felt like I became steadier and stronger in my core,” Meltzer said. Prior to yoga, she described herself as a “wall walker,”  someone who felt safer holding onto the wall in order to get around. “To be able to stand on one leg and feel balanced is amazing.”

Susan Gould Fogerite, director of research for the Institute for Complementary and Alternative Medicine in the School of Health Related Professions, said that although there is widespread evidence that yoga is being used as a form of exercise by those with MS, much of the feedback has been anecdotal and there isn’t much empirical data regarding its safety and efficacy.

This is why she and her colleagues, Evan Cohen and David Kietrys, physical therapists and associate professors in the School of Health Related Professions at Stratford, decided to undertake the small pilot study, believing that a specialized yoga program for MS patients – which incorporates mind, body and spirit – would be beneficial to everyday living.

What they discovered at the end of the eight-week trial was that those who participated were better able to walk for short distances and longer periods of time, had better balance while reaching backwards, fine motor coordination, and were better able to go from sitting to standing. Their quality of life also improved in perceived mental health, concentration, bladder control, walking, and vision, with a decrease in pain and fatigue.

 “Yoga is not just exercise, it is a whole system of living,” said Fogerite, an associate professor, who, along with Kietrys, will present the results on September 26 at the Symposium on Yoga Research at the Kripalu Institute in Massachusetts. “The panel of experts who advised us on the trial wanted to make sure that we provided a fully integrated program that included philosophy, breathing practices, postures, relaxation and meditation.”

The yoga pilot trial was held at Still Point Yoga Center in Laurel Springs, a southern New Jersey town close to Philadelphia. Of the 72 individuals who were interested in participating, only 16 were eligible based on medical and other criteria and availability. Of those, 15 were enrolled and 14 completed the program after one person had to withdraw because of an unrelated health problem.

Meltzer and the other women who participated in the trial ranged in age from 34 to 64. Some had been diagnosed with MS within the last two years while others had been living with the illness for up to 26 years. For 90 minutes, twice a week for two months, they practiced techniques and exercises that would improve their posture, help to increase stamina, and teach them how to relax and focus.

“This study, I hope, is one of many that will give us the clinical information we need,” said Fogerite. “Yoga is not currently being widely prescribed for people with MS, although it might turn out to be a very helpful treatment.”

The yoga practices were done by the women in the study sitting, standing, or lying on yoga mats, and using metal folding chairs situated close to the wall to provide them with more support.

“What was so nice about this experience was that although everyone was at a different level of the disease, we felt like we were all together, so I think the camaraderie helped,” said Meltzer. “And it wasn’t just about gaining more mobility and balance in our legs but our arms and necks felt stronger as well.”

Fogerite said a larger randomized controlled trial would be needed to determine whether yoga could be used as a prescribed treatment for individuals with moderate disability due to MS. More than 2.3 million people – two to three times more women than men – throughout the world are diagnosed with this disease which can cause poor coordination, loss of balance, slurred speech, tremors, numbness, extreme fatigue and problems with memory and concentration.

“When I was first diagnosed I no longer felt safe in my own body,” Meltzer said. “I didn’t trust my body at all.  What the program did was really bring that trust back.”

(Source: news.rutgers.edu)

Filed under MS yoga quality of life meditation psychology neuroscience science

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Only 25 Minutes of Mindfulness Meditation Alleviates Stress
Mindfulness meditation has become an increasingly popular way for people to improve their mental and physical health, yet most research supporting its benefits has focused on lengthy, weeks-long training programs.
New research from Carnegie Mellon University is the first to show that brief mindfulness meditation practice — 25 minutes for three consecutive days — alleviates psychological stress. Published in the journal “Psychoneuroendocrinology,” the study investigates how mindfulness meditation affects people’s ability to be resilient under stress.
"More and more people report using meditation practices for stress reduction, but we know very little about how much you need to do for stress reduction and health benefits," said lead author J. David Creswell, associate professor of psychology in the Dietrich College of Humanities and Social Sciences.
For the study, Creswell and his research team had 66 healthy individuals aged 18-30 years old participate in a three-day experiment. Some participants went through a brief mindfulness meditation training program; for 25 minutes for three consecutive days, the individuals were given breathing exercises to help them monitor their breath and pay attention to their present moment experiences. A second group of participants completed a matched three-day cognitive training program in which they were asked to critically analyze poetry in an effort to enhance problem-solving skills.
Following the final training activity, all participants were asked to complete stressful speech and math tasks in front of stern-faced evaluators. Each individual reported their stress levels in response to stressful speech and math performance stress tasks, and provided saliva samples for measurement of cortisol, commonly referred to as the stress hormone.
The participants who received the brief mindfulness meditation training reported reduced stress perceptions to the speech and math tasks, indicating that the mindfulness meditation fostered psychological stress resilience. More interestingly, on the biological side, the mindfulness meditation participants showed greater cortisol reactivity.
"When you initially learn mindfulness mediation practices, you have to cognitively work at it — especially during a stressful task," said Creswell. "And, these active cognitive efforts may result in the task feeling less stressful, but they may also have physiological costs with higher cortisol production."
Creswell’s group is now testing the possibility that mindfulness can become more automatic and easy to use with long-term mindfulness meditation training, which may result in reduced cortisol reactivity.

Only 25 Minutes of Mindfulness Meditation Alleviates Stress

Mindfulness meditation has become an increasingly popular way for people to improve their mental and physical health, yet most research supporting its benefits has focused on lengthy, weeks-long training programs.

New research from Carnegie Mellon University is the first to show that brief mindfulness meditation practice — 25 minutes for three consecutive days — alleviates psychological stress. Published in the journal “Psychoneuroendocrinology,” the study investigates how mindfulness meditation affects people’s ability to be resilient under stress.

"More and more people report using meditation practices for stress reduction, but we know very little about how much you need to do for stress reduction and health benefits," said lead author J. David Creswell, associate professor of psychology in the Dietrich College of Humanities and Social Sciences.

For the study, Creswell and his research team had 66 healthy individuals aged 18-30 years old participate in a three-day experiment. Some participants went through a brief mindfulness meditation training program; for 25 minutes for three consecutive days, the individuals were given breathing exercises to help them monitor their breath and pay attention to their present moment experiences. A second group of participants completed a matched three-day cognitive training program in which they were asked to critically analyze poetry in an effort to enhance problem-solving skills.

Following the final training activity, all participants were asked to complete stressful speech and math tasks in front of stern-faced evaluators. Each individual reported their stress levels in response to stressful speech and math performance stress tasks, and provided saliva samples for measurement of cortisol, commonly referred to as the stress hormone.

The participants who received the brief mindfulness meditation training reported reduced stress perceptions to the speech and math tasks, indicating that the mindfulness meditation fostered psychological stress resilience. More interestingly, on the biological side, the mindfulness meditation participants showed greater cortisol reactivity.

"When you initially learn mindfulness mediation practices, you have to cognitively work at it — especially during a stressful task," said Creswell. "And, these active cognitive efforts may result in the task feeling less stressful, but they may also have physiological costs with higher cortisol production."

Creswell’s group is now testing the possibility that mindfulness can become more automatic and easy to use with long-term mindfulness meditation training, which may result in reduced cortisol reactivity.

Filed under meditation mindfulness meditation stress psychology neuroscience science

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How your brain works during meditation
Mindfulness. Zen. Acem. Meditation drumming. Chakra. Buddhist and transcendental meditation. There are countless ways of meditating, but the purpose behind them all remains basically the same: more peace, less stress, better concentration, greater self-awareness and better processing of thoughts and feelings.
But which of these techniques should a poor stressed-out wretch choose? What does the research say? Very little – at least until now.
Nondirective or concentrative meditation?
A team of researchers at the Norwegian University of Science and Technology (NTNU), the University of Oslo and the University of Sydney is now working to determine how the brain works during different kinds of meditation.
Different meditation techniques can actually be divided into two main groups. One type is concentrative meditation, where the meditating person focuses attention on his or her breathing or on specific thoughts, and in doing so, suppresses other thoughts. The other type may be called nondirective meditation, where the person who is meditating effortlessly focuses on his or her breathing or on a meditation sound, but beyond that the mind is allowed to wander as it pleases. Some modern meditation methods are of this nondirective kind.
“No one knows how the brain works when you meditate. That is why I’d like to study it,” says Jian Xu, who is a physician at St. Olavs Hospital and a researcher at the Department of Circulation and Medical Imaging at NTNU.
Two different ways to meditate
Fourteen people who had extensive experience with the Norwegian technique Acem meditation were tested in an MRI machine. In addition to simple resting, they undertook two different mental meditation activities, nondirective meditation and a more concentrative meditation task. The research team wanted to test people who were used to meditation because it meant fewer misunderstandings about what the subjects should actually be doing while they lay in the MRI machine.
The results were recently published in the journal “Frontiers in Human Neuroscience”.
Nondirective meditation led to higher activity than during rest in the part of the brain dedicated to processing self-related thoughts and feelings. When test subjects performed concentrative meditation, the activity in this part of the brain was almost the same as when they were just resting.
A place for the mind to rest
“I was surprised that the activity of the brain was greatest when the person’s thoughts wandered freely on their own, rather than when the brain worked to be more strongly focused,” said Xu. “When the subjects stopped doing a specific task and were not really doing anything special, there was an increase in activity in the area of the brain where we process thoughts and feelings. It is described as a kind of resting network. And it was this area that was most active during nondirective meditation.”
Provides greater freedom for the brain
“The study indicates that nondirective meditation allows for more room to process memories and emotions than during concentrated meditation,” says Svend Davanger, a neuroscientist at the University of Oslo, and co-author of the study.
“This area of the brain has its highest activity when we rest. It represents a kind of basic operating system, a resting network that takes over when external tasks do not require our attention. It is remarkable that a mental task like nondirective meditation results in even higher activity in this network than regular rest,” says Davanger.
Meditating researchers
Most of the research team behind the study do not practice meditation, although three do: Professors Are Holen and Øyvind Ellingsen from NTNU and Professor Svend Davanger from the University of Oslo.
Acem meditation is a technique that falls under the category of nondirective meditation. Davanger believes that good research depends on having a team that can combine personal experience with meditation with a critical attitude towards results.
“Meditation is an activity that is practiced by millions of people. It is important that we find out how this really works. In recent years there has been a sharp increase in international research on meditation. Several prestigious universities in the US  spend a great deal of money to research in the field. So I think it is important that we are also active,” says Davanger.

How your brain works during meditation

Mindfulness. Zen. Acem. Meditation drumming. Chakra. Buddhist and transcendental meditation. There are countless ways of meditating, but the purpose behind them all remains basically the same: more peace, less stress, better concentration, greater self-awareness and better processing of thoughts and feelings.

But which of these techniques should a poor stressed-out wretch choose? What does the research say? Very little – at least until now.

Nondirective or concentrative meditation?

A team of researchers at the Norwegian University of Science and Technology (NTNU), the University of Oslo and the University of Sydney is now working to determine how the brain works during different kinds of meditation.

Different meditation techniques can actually be divided into two main groups. One type is concentrative meditation, where the meditating person focuses attention on his or her breathing or on specific thoughts, and in doing so, suppresses other thoughts. The other type may be called nondirective meditation, where the person who is meditating effortlessly focuses on his or her breathing or on a meditation sound, but beyond that the mind is allowed to wander as it pleases. Some modern meditation methods are of this nondirective kind.

“No one knows how the brain works when you meditate. That is why I’d like to study it,” says Jian Xu, who is a physician at St. Olavs Hospital and a researcher at the Department of Circulation and Medical Imaging at NTNU.

Two different ways to meditate

Fourteen people who had extensive experience with the Norwegian technique Acem meditation were tested in an MRI machine. In addition to simple resting, they undertook two different mental meditation activities, nondirective meditation and a more concentrative meditation task. The research team wanted to test people who were used to meditation because it meant fewer misunderstandings about what the subjects should actually be doing while they lay in the MRI machine.

The results were recently published in the journal “Frontiers in Human Neuroscience”.

Nondirective meditation led to higher activity than during rest in the part of the brain dedicated to processing self-related thoughts and feelings. When test subjects performed concentrative meditation, the activity in this part of the brain was almost the same as when they were just resting.

A place for the mind to rest

“I was surprised that the activity of the brain was greatest when the person’s thoughts wandered freely on their own, rather than when the brain worked to be more strongly focused,” said Xu. “When the subjects stopped doing a specific task and were not really doing anything special, there was an increase in activity in the area of the brain where we process thoughts and feelings. It is described as a kind of resting network. And it was this area that was most active during nondirective meditation.”

Provides greater freedom for the brain

“The study indicates that nondirective meditation allows for more room to process memories and emotions than during concentrated meditation,” says Svend Davanger, a neuroscientist at the University of Oslo, and co-author of the study.

“This area of the brain has its highest activity when we rest. It represents a kind of basic operating system, a resting network that takes over when external tasks do not require our attention. It is remarkable that a mental task like nondirective meditation results in even higher activity in this network than regular rest,” says Davanger.

Meditating researchers

Most of the research team behind the study do not practice meditation, although three do: Professors Are Holen and Øyvind Ellingsen from NTNU and Professor Svend Davanger from the University of Oslo.

Acem meditation is a technique that falls under the category of nondirective meditation. Davanger believes that good research depends on having a team that can combine personal experience with meditation with a critical attitude towards results.

“Meditation is an activity that is practiced by millions of people. It is important that we find out how this really works. In recent years there has been a sharp increase in international research on meditation. Several prestigious universities in the US  spend a great deal of money to research in the field. So I think it is important that we are also active,” says Davanger.

Filed under meditation attention default mode network memory nondirective meditation neuroscience science

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Laughter May Work Like Meditation in the Brain
Laughter triggers brain waves similar to those associated with meditation, according to a small new study.
It also found that other forms of stimulation produce different types of brain waves.
The study included 31 people whose brain waves were monitored while they watched humorous, spiritual or distressing video clips. While watching the humorous videos, the volunteers’ brains had high levels of gamma waves, which are the same ones produced during meditation, researchers found.
During the spiritual videos, the participants’ brains showed higher levels of alpha brain waves, similar to when a person is at rest. The distressing videos caused flat brain wave bands, similar to when a person feels detached, nonresponsive or doesn’t want to be in a certain situation.
Researchers were led by Lee Berk, an associate professor in the School of Allied Health Professions, and an associate research professor of pathology and human anatomy in the School of Medicine, at Loma Linda University, in California.
The study was scheduled to be presented Sunday at the Experimental Biology meeting held in San Diego. The data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.
“What we have found in our study is that humor associated with mirthful laughter sustains high-amplitude gamma-band oscillations. Gamma is the only frequency found in every part of the brain,” Berk said in a university news release.
“What this means is that humor actually engages the entire brain — it is a whole brain experience with the gamma wave band frequency and humor, similar to meditation, holds it there; we call this being ‘in the zone,’” Berk explained.
He said that with laughter, “it’s as if the brain gets a workout.” This effect is important because it “allows for the subjective feeling states of being able to think more clearly and have more integrative thoughts,” Berk said. “This is of great value to individuals who need or want to revisit, reorganize or rearrange various aspects of their lives or experiences, to make them feel whole or more focused.”

Laughter May Work Like Meditation in the Brain

Laughter triggers brain waves similar to those associated with meditation, according to a small new study.

It also found that other forms of stimulation produce different types of brain waves.

The study included 31 people whose brain waves were monitored while they watched humorous, spiritual or distressing video clips. While watching the humorous videos, the volunteers’ brains had high levels of gamma waves, which are the same ones produced during meditation, researchers found.

During the spiritual videos, the participants’ brains showed higher levels of alpha brain waves, similar to when a person is at rest. The distressing videos caused flat brain wave bands, similar to when a person feels detached, nonresponsive or doesn’t want to be in a certain situation.

Researchers were led by Lee Berk, an associate professor in the School of Allied Health Professions, and an associate research professor of pathology and human anatomy in the School of Medicine, at Loma Linda University, in California.

The study was scheduled to be presented Sunday at the Experimental Biology meeting held in San Diego. The data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

“What we have found in our study is that humor associated with mirthful laughter sustains high-amplitude gamma-band oscillations. Gamma is the only frequency found in every part of the brain,” Berk said in a university news release.

“What this means is that humor actually engages the entire brain — it is a whole brain experience with the gamma wave band frequency and humor, similar to meditation, holds it there; we call this being ‘in the zone,’” Berk explained.

He said that with laughter, “it’s as if the brain gets a workout.” This effect is important because it “allows for the subjective feeling states of being able to think more clearly and have more integrative thoughts,” Berk said. “This is of great value to individuals who need or want to revisit, reorganize or rearrange various aspects of their lives or experiences, to make them feel whole or more focused.”

Filed under laughter brainwaves meditation gamma oscillations Experimental Biology Meeting 2014 neuroscience science

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Meditation helps pinpoint neurological differences between two types of love
These findings won’t appear on any Hallmark card, but romantic love tends to activate the same reward areas of the brain as cocaine, research has shown.
Now Yale School of Medicine researchers studying meditators have found that a more selfless variety of love — a deep and genuine wish for the happiness of others without expectation of reward — actually turns off the same reward areas that light up when lovers see each other.
“When we truly, selflessly wish for the well-being of others, we’re not getting that same rush of excitement that comes with, say, a tweet from our romantic love interest, because it’s not about us at all,” said Judson Brewer, adjunct professor of psychiatry at Yale now at the University of Massachusetts.
Brewer and Kathleen Garrison, postdoctoral researcher in Yale’s Department of Psychiatry, report their findings in a paper scheduled to be published online Feb. 12 in the journal Brain and Behavior.
The neurological boundaries between these two types of love become clear in fMRI scans of experienced meditators. The reward centers of the brain that are strongly activated by a lover’s face (or a picture of cocaine) are almost completely turned off when a meditator is instructed to silently repeat sayings such as “May all beings be happy.”
Such mindfulness meditations are a staple of Buddhism and are now commonly practiced in Western stress reduction programs, Brewer notes. The tranquility of this selfless love for others — exemplified in such religious figures such as Mother Theresa or the Dalai Llama — is diametrically opposed to the anxiety caused by a lovers’ quarrel or extended separation. And it carries its own rewards.
“The intent of this practice is to specifically foster selfless love — just putting it out there and not looking for or wanting anything in return,” Brewer said. “If you’re wondering where the reward is in being selfless, just reflect on how it feels when you see people out there helping others, or even when you hold the door for somebody the next time you are at Starbucks.”

Meditation helps pinpoint neurological differences between two types of love

These findings won’t appear on any Hallmark card, but romantic love tends to activate the same reward areas of the brain as cocaine, research has shown.

Now Yale School of Medicine researchers studying meditators have found that a more selfless variety of love — a deep and genuine wish for the happiness of others without expectation of reward — actually turns off the same reward areas that light up when lovers see each other.

“When we truly, selflessly wish for the well-being of others, we’re not getting that same rush of excitement that comes with, say, a tweet from our romantic love interest, because it’s not about us at all,” said Judson Brewer, adjunct professor of psychiatry at Yale now at the University of Massachusetts.

Brewer and Kathleen Garrison, postdoctoral researcher in Yale’s Department of Psychiatry, report their findings in a paper scheduled to be published online Feb. 12 in the journal Brain and Behavior.

The neurological boundaries between these two types of love become clear in fMRI scans of experienced meditators. The reward centers of the brain that are strongly activated by a lover’s face (or a picture of cocaine) are almost completely turned off when a meditator is instructed to silently repeat sayings such as “May all beings be happy.”

Such mindfulness meditations are a staple of Buddhism and are now commonly practiced in Western stress reduction programs, Brewer notes. The tranquility of this selfless love for others — exemplified in such religious figures such as Mother Theresa or the Dalai Llama — is diametrically opposed to the anxiety caused by a lovers’ quarrel or extended separation. And it carries its own rewards.

“The intent of this practice is to specifically foster selfless love — just putting it out there and not looking for or wanting anything in return,” Brewer said. “If you’re wondering where the reward is in being selfless, just reflect on how it feels when you see people out there helping others, or even when you hold the door for somebody the next time you are at Starbucks.”

Filed under meditation loving kindness fMRI reward system neuroimaging psychology neuroscience science

1,133 notes

Gene expression changes with meditation
With evidence growing that meditation can have beneficial health effects, scientists have sought to understand how these practices physically affect the body.
A new study by researchers in Wisconsin, Spain, and France reports the first evidence of specific molecular changes in the body following a period of mindfulness meditation.
The study investigated the effects of a day of intensive mindfulness practice in a group of experienced meditators, compared to a group of untrained control subjects who engaged in quiet non-meditative activities. After eight hours of mindfulness practice, the meditators showed a range of genetic and molecular differences, including altered levels of gene-regulating machinery and reduced levels of pro-inflammatory genes, which in turn correlated with faster physical recovery from a stressful situation.
"To the best of our knowledge, this is the first paper that shows rapid alterations in gene expression within subjects associated with mindfulness meditation practice," says study author Richard J. Davidson, founder of the Center for Investigating Healthy Minds and the William James and Vilas Professor of Psychology and Psychiatry at the University of Wisconsin-Madison.
"Most interestingly, the changes were observed in genes that are the current targets of anti-inflammatory and analgesic drugs," says Perla Kaliman, first author of the article and a researcher at the Institute of Biomedical Research of Barcelona, Spain (IIBB-CSIC-IDIBAPS), where the molecular analyses were conducted.
The study was published in the journal Psychoneuroendocrinology.
Mindfulness-based trainings have shown beneficial effects on inflammatory disorders in prior clinical studies and are endorsed by the American Heart Association as a preventative intervention. The new results provide a possible biological mechanism for therapeutic effects.
The results show a down-regulation of genes that have been implicated in inflammation. The affected genes include the pro-inflammatory genes RIPK2 and COX2 as well as several histone deacetylase (HDAC) genes, which regulate the activity of other genes epigenetically by removing a type of chemical tag. What’s more, the extent to which some of those genes were downregulated was associated with faster cortisol recovery to a social stress test involving an impromptu speech and tasks requiring mental calculations performed in front of an audience and video camera.
Perhaps surprisingly, the researchers say, there was no difference in the tested genes between the two groups of people at the start of the study. The observed effects were seen only in the meditators following mindfulness practice. In addition, several other DNA-modifying genes showed no differences between groups, suggesting that the mindfulness practice specifically affected certain regulatory pathways.
However, it is important to note that the study was not designed to distinguish any effects of long-term meditation training from those of a single day of practice. Instead, the key result is that meditators experienced genetic changes following mindfulness practice that were not seen in the non-meditating group after other quiet activities — an outcome providing proof of principle that mindfulness practice can lead to epigenetic alterations of the genome.
Previous studies in rodents and in people have shown dynamic epigenetic responses to physical stimuli such as stress, diet, or exercise within just a few hours.
"Our genes are quite dynamic in their expression and these results suggest that the calmness of our mind can actually have a potential influence on their expression," Davidson says.
"The regulation of HDACs and inflammatory pathways may represent some of the mechanisms underlying the therapeutic potential of mindfulness-based interventions," Kaliman says. "Our findings set the foundation for future studies to further assess meditation strategies for the treatment of chronic inflammatory conditions."

Gene expression changes with meditation

With evidence growing that meditation can have beneficial health effects, scientists have sought to understand how these practices physically affect the body.

A new study by researchers in Wisconsin, Spain, and France reports the first evidence of specific molecular changes in the body following a period of mindfulness meditation.

The study investigated the effects of a day of intensive mindfulness practice in a group of experienced meditators, compared to a group of untrained control subjects who engaged in quiet non-meditative activities. After eight hours of mindfulness practice, the meditators showed a range of genetic and molecular differences, including altered levels of gene-regulating machinery and reduced levels of pro-inflammatory genes, which in turn correlated with faster physical recovery from a stressful situation.

"To the best of our knowledge, this is the first paper that shows rapid alterations in gene expression within subjects associated with mindfulness meditation practice," says study author Richard J. Davidson, founder of the Center for Investigating Healthy Minds and the William James and Vilas Professor of Psychology and Psychiatry at the University of Wisconsin-Madison.

"Most interestingly, the changes were observed in genes that are the current targets of anti-inflammatory and analgesic drugs," says Perla Kaliman, first author of the article and a researcher at the Institute of Biomedical Research of Barcelona, Spain (IIBB-CSIC-IDIBAPS), where the molecular analyses were conducted.

The study was published in the journal Psychoneuroendocrinology.

Mindfulness-based trainings have shown beneficial effects on inflammatory disorders in prior clinical studies and are endorsed by the American Heart Association as a preventative intervention. The new results provide a possible biological mechanism for therapeutic effects.

The results show a down-regulation of genes that have been implicated in inflammation. The affected genes include the pro-inflammatory genes RIPK2 and COX2 as well as several histone deacetylase (HDAC) genes, which regulate the activity of other genes epigenetically by removing a type of chemical tag. What’s more, the extent to which some of those genes were downregulated was associated with faster cortisol recovery to a social stress test involving an impromptu speech and tasks requiring mental calculations performed in front of an audience and video camera.

Perhaps surprisingly, the researchers say, there was no difference in the tested genes between the two groups of people at the start of the study. The observed effects were seen only in the meditators following mindfulness practice. In addition, several other DNA-modifying genes showed no differences between groups, suggesting that the mindfulness practice specifically affected certain regulatory pathways.

However, it is important to note that the study was not designed to distinguish any effects of long-term meditation training from those of a single day of practice. Instead, the key result is that meditators experienced genetic changes following mindfulness practice that were not seen in the non-meditating group after other quiet activities — an outcome providing proof of principle that mindfulness practice can lead to epigenetic alterations of the genome.

Previous studies in rodents and in people have shown dynamic epigenetic responses to physical stimuli such as stress, diet, or exercise within just a few hours.

"Our genes are quite dynamic in their expression and these results suggest that the calmness of our mind can actually have a potential influence on their expression," Davidson says.

"The regulation of HDACs and inflammatory pathways may represent some of the mechanisms underlying the therapeutic potential of mindfulness-based interventions," Kaliman says. "Our findings set the foundation for future studies to further assess meditation strategies for the treatment of chronic inflammatory conditions."

Filed under meditation gene expression inflammation HDAC genetics neuroscience science

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Time perception altered by mindfulness meditation
New published research from psychologists at the universities of Kent and Witten/Herdecke has shown that mindfulness meditation has the ability to temporarily alter practitioners’ perceptions of time – a finding that has wider implications for the use of mindfulness both as an everyday practice, and in clinical treatments and interventions.
Led by Dr Robin Kramer from Kent’s School of Psychology, the research team hypothesised that, given mindfulness’ emphasis on moment-to-moment awareness, mindfulness meditation would slow down time and produce the feeling that short periods of time lasted longer.
To test this hypothesis, they used a temporal bisection task, which allows researchers to measure where each individual subjectively splits a period of time in half. Participants’ responses to this task were collected twice, once before and then again after a listening task. By separating people into two groups, participants listened for ten minutes to either an audiobook or a meditation exercise designed to focus their attention on the movement of breath in the body. The results showed that the control group (audiobook) didn’t change in their responses after the listening task compared with before. However, meditation led to a relative overestimation of durations i.e. time periods felt longer than they had before.
The reasons for this have been interpreted by Dr Kramer and team as the result of attentional changes, producing either improved attentional resources that allow increased attention to the processing of time, or a shift to internally-oriented attention that would have the same effect.
Dr Kramer said: ‘Our findings represent some of the first to demonstrate how mindfulness meditation can alter the perception of time. Given the increasing popularity of mindfulness in everyday practice, its relationship with time perception may provide an important step in our understanding of this pervasive, ancient practice in our modern world.’
Dr Kramer also explained that the benefits of mindfulness and mindfulness-based therapies in a variety of domains are now being identified. These include decreases in rumination, improvements in cognitive flexibility, working memory capacity and sustained attention, and reductions in reactivity, anxiety and depressive symptoms. Mindfulness-based treatments also appear to provide broad antidepressant and antianxiety effects, as well as decreases in general psychological distress. As such, these interventions have been applied with a variety of patients, including those suffering from fibromyalgia, psoriasis, cancer, binge eating and chronic pain.
Dr Dinkar Sharma, Senior Lecturer in Psychology at Kent, commented: ‘Demonstrating that mindfulness has an effect on time perception is important because it opens up the opportunity that mindfulness could be used to alter psychological disorders that are associated with a range of distortions in the perception of time - such as disorders of memory, emotion and addiction.’
Dr Ulrich Weger, of Witten/Herdecke’s Department of Psychology and Psychotherapy, concluded by stating that ‘the impact of a brief mindfulness exercise on elementary processes such as time perception is remarkable’.

Time perception altered by mindfulness meditation

New published research from psychologists at the universities of Kent and Witten/Herdecke has shown that mindfulness meditation has the ability to temporarily alter practitioners’ perceptions of time – a finding that has wider implications for the use of mindfulness both as an everyday practice, and in clinical treatments and interventions.

Led by Dr Robin Kramer from Kent’s School of Psychology, the research team hypothesised that, given mindfulness’ emphasis on moment-to-moment awareness, mindfulness meditation would slow down time and produce the feeling that short periods of time lasted longer.

To test this hypothesis, they used a temporal bisection task, which allows researchers to measure where each individual subjectively splits a period of time in half. Participants’ responses to this task were collected twice, once before and then again after a listening task. By separating people into two groups, participants listened for ten minutes to either an audiobook or a meditation exercise designed to focus their attention on the movement of breath in the body. The results showed that the control group (audiobook) didn’t change in their responses after the listening task compared with before. However, meditation led to a relative overestimation of durations i.e. time periods felt longer than they had before.

The reasons for this have been interpreted by Dr Kramer and team as the result of attentional changes, producing either improved attentional resources that allow increased attention to the processing of time, or a shift to internally-oriented attention that would have the same effect.

Dr Kramer said: ‘Our findings represent some of the first to demonstrate how mindfulness meditation can alter the perception of time. Given the increasing popularity of mindfulness in everyday practice, its relationship with time perception may provide an important step in our understanding of this pervasive, ancient practice in our modern world.’

Dr Kramer also explained that the benefits of mindfulness and mindfulness-based therapies in a variety of domains are now being identified. These include decreases in rumination, improvements in cognitive flexibility, working memory capacity and sustained attention, and reductions in reactivity, anxiety and depressive symptoms. Mindfulness-based treatments also appear to provide broad antidepressant and antianxiety effects, as well as decreases in general psychological distress. As such, these interventions have been applied with a variety of patients, including those suffering from fibromyalgia, psoriasis, cancer, binge eating and chronic pain.

Dr Dinkar Sharma, Senior Lecturer in Psychology at Kent, commented: ‘Demonstrating that mindfulness has an effect on time perception is important because it opens up the opportunity that mindfulness could be used to alter psychological disorders that are associated with a range of distortions in the perception of time - such as disorders of memory, emotion and addiction.’

Dr Ulrich Weger, of Witten/Herdecke’s Department of Psychology and Psychotherapy, concluded by stating that ‘the impact of a brief mindfulness exercise on elementary processes such as time perception is remarkable’.

Filed under time perception meditation mindful meditation emotion memory psychology neuroscience science

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A 20-minute bout of yoga stimulates brain function immediately after
Researchers report that a single, 20-minute session of Hatha yoga significantly improved participants’ speed and accuracy on tests of working memory and inhibitory control, two measures of brain function associated with the ability to maintain focus and take in, retain and use new information. Participants performed significantly better immediately after the yoga practice than after moderate to vigorous aerobic exercise for the same amount of time.
The 30 study subjects were young, female, undergraduate students. The new findings appear in the Journal of Physical Activity and Health.
“Yoga is an ancient Indian science and way of life that includes not only physical movements and postures but also regulated breathing and meditation,” said Neha Gothe, who led the study while a graduate student at the University of Illinois at Urbana-Champaign. Gothe now is a professor of kinesiology, health and sport studies at Wayne State University in Detroit. “The practice involves an active attentional or mindfulness component but its potential benefits have not been thoroughly explored.”
“Yoga is becoming an increasingly popular form of exercise in the U.S. and it is imperative to systematically examine its health benefits, especially the mental health benefits that this unique mind-body form of activity may offer,” said Illinois kinesiology and community health professor Edward McAuley, who directs the Exercise Psychology Laboratory where the study was conducted.
The yoga intervention involved a 20-minute progression of seated, standing and supine yoga postures that included isometric contraction and relaxation of different muscle groups and regulated breathing. The session concluded with a meditative posture and deep breathing.
Participants also completed an aerobic exercise session where they walked or jogged on a treadmill for 20 minutes. Each subject worked out at a suitable speed and incline of the treadmill, with the goal of maintaining 60 to 70 percent of her maximum heart rate throughout the exercise session.
“This range was chosen to replicate previous findings that have shown improved cognitive performance in response to this intensity,” the researchers reported.
Gothe and her colleagues were surprised to see that participants showed more improvement in their reaction times and accuracy on cognitive tasks after yoga practice than after the aerobic exercise session, which showed no significant improvements on the working memory and inhibitory control scores.
“It appears that following yoga practice, the participants were better able to focus their mental resources, process information quickly, more accurately and also learn, hold and update pieces of information more effectively than after performing an aerobic exercise bout,” Gothe said. “The breathing and meditative exercises aim at calming the mind and body and keeping distracting thoughts away while you focus on your body, posture or breath. Maybe these processes translate beyond yoga practice when you try to perform mental tasks or day-to-day activities.”
Many factors could explain the results, Gothe said. “Enhanced self-awareness that comes with meditational exercises is just one of the possible mechanisms. Besides, meditation and breathing exercises are known to reduce anxiety and stress, which in turn can improve scores on some cognitive tests,” she said.
“We only examined the effects of a 20-minute bout of yoga and aerobic exercise in this study among female undergraduates,” McAuley said. “However, this study is extremely timely and the results will enable yoga researchers to power and design their interventions in the future. We see similar promising findings among older adults as well. Yoga research is in its nascent stages and with its increasing popularity across the globe, researchers need to adopt rigorous systematic approaches to examine not only its cognitive but also physical health benefits across the lifespan.”

A 20-minute bout of yoga stimulates brain function immediately after

Researchers report that a single, 20-minute session of Hatha yoga significantly improved participants’ speed and accuracy on tests of working memory and inhibitory control, two measures of brain function associated with the ability to maintain focus and take in, retain and use new information. Participants performed significantly better immediately after the yoga practice than after moderate to vigorous aerobic exercise for the same amount of time.

The 30 study subjects were young, female, undergraduate students. The new findings appear in the Journal of Physical Activity and Health.

“Yoga is an ancient Indian science and way of life that includes not only physical movements and postures but also regulated breathing and meditation,” said Neha Gothe, who led the study while a graduate student at the University of Illinois at Urbana-Champaign. Gothe now is a professor of kinesiology, health and sport studies at Wayne State University in Detroit. “The practice involves an active attentional or mindfulness component but its potential benefits have not been thoroughly explored.”

“Yoga is becoming an increasingly popular form of exercise in the U.S. and it is imperative to systematically examine its health benefits, especially the mental health benefits that this unique mind-body form of activity may offer,” said Illinois kinesiology and community health professor Edward McAuley, who directs the Exercise Psychology Laboratory where the study was conducted.

The yoga intervention involved a 20-minute progression of seated, standing and supine yoga postures that included isometric contraction and relaxation of different muscle groups and regulated breathing. The session concluded with a meditative posture and deep breathing.

Participants also completed an aerobic exercise session where they walked or jogged on a treadmill for 20 minutes. Each subject worked out at a suitable speed and incline of the treadmill, with the goal of maintaining 60 to 70 percent of her maximum heart rate throughout the exercise session.

“This range was chosen to replicate previous findings that have shown improved cognitive performance in response to this intensity,” the researchers reported.

Gothe and her colleagues were surprised to see that participants showed more improvement in their reaction times and accuracy on cognitive tasks after yoga practice than after the aerobic exercise session, which showed no significant improvements on the working memory and inhibitory control scores.

“It appears that following yoga practice, the participants were better able to focus their mental resources, process information quickly, more accurately and also learn, hold and update pieces of information more effectively than after performing an aerobic exercise bout,” Gothe said. “The breathing and meditative exercises aim at calming the mind and body and keeping distracting thoughts away while you focus on your body, posture or breath. Maybe these processes translate beyond yoga practice when you try to perform mental tasks or day-to-day activities.”

Many factors could explain the results, Gothe said. “Enhanced self-awareness that comes with meditational exercises is just one of the possible mechanisms. Besides, meditation and breathing exercises are known to reduce anxiety and stress, which in turn can improve scores on some cognitive tests,” she said.

“We only examined the effects of a 20-minute bout of yoga and aerobic exercise in this study among female undergraduates,” McAuley said. “However, this study is extremely timely and the results will enable yoga researchers to power and design their interventions in the future. We see similar promising findings among older adults as well. Yoga research is in its nascent stages and with its increasing popularity across the globe, researchers need to adopt rigorous systematic approaches to examine not only its cognitive but also physical health benefits across the lifespan.”

Filed under yoga hatha yoga working memory cognition cognitive performance meditation psychology neuroscience science

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Mind-body Genomics

A new study from investigators at the Benson-Henry Institute for Mind/Body Medicine at Massachusetts General Hospital and Beth Israel Deaconess Medical Center finds that eliciting the relaxation response—a physiologic state of deep rest induced by practices such as meditation, yoga, deep breathing and prayer—produces immediate changes in the expression of genes involved in immune function, energy metabolism and insulin secretion.

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“Many studies have shown that mind/body interventions like the relaxation response can reduce stress and enhance wellness in healthy individuals and counteract the adverse clinical effects of stress in conditions like hypertension, anxiety, diabetes and aging,” said Herbert Benson, HMS professor of medicine at Mass General and co-senior author of thereport.

Benson is director emeritus of the Benson-Henry Institute.

“Now for the first time we’ve identified the key physiological hubs through which these benefits might be induced,” he said.

Published in the open-access journal PLOS ONE, the study combined advanced expression profiling and systems biology analysis to both identify genes affected by relaxation response practice and to determine the potential biological relevance of those changes.

“Some of the biological pathways we identify as being regulated by relaxation response practice are already known to play specific roles in stress, inflammation and human disease. For others, the connections are still speculative, but this study is generating new hypotheses for further investigation,” said Towia Libermann, HMS associate professor of medicine at Beth Israel Deaconess and co-senior author of the study.

Benson first described the relaxation response—the physiologic opposite of the fight-or-flight response—almost 40 years ago, and his team has pioneered the application of mind/body techniques to a wide range of health problems. Studies in many peer-reviewed journals have documented how the relaxation response both alleviates symptoms of anxiety and many other disorders and also affects factors such as heart rate, blood pressure, oxygen consumption and brain activity. 

In 2008, Benson and Libermann led a study finding that long-term practice of the relaxation response changed the expression of genes involved with the body’s response to stress. The current study examined changes produced during a single session of relaxation response practice, as well as those taking place over longer periods of time.

The study enrolled a group of 26 healthy adults with no experience in relaxation response practice, who then completed an 8-week relaxation-response training course.

Before they started their training, they went through what was essentially a control group session: Blood samples were taken before and immediately after the participants listened to a 20-minute health education CD and again 15 minutes later. After completing the training course, a similar set of blood tests was taken before and after participants listened to a 20-minute CD used to elicit the relaxation response as part of daily practice. 

The sets of blood tests taken before the training program were designated “novice,” and those taken after training completion were called “short-term practitioners.” For further comparison, a similar set of blood samples was taken from a group of 25 individuals with 4 to 25 years’ experience regularly eliciting the relaxation response through many different techniques before and after they listened to the same relaxation response CD.

Blood samples from all participants were analyzed to determine the expression of more than 22,000 genes at the different time points.

The results revealed significant changes in the expression of several important groups of genes between the novice samples and those from both the short- and long-term sets. Even more pronounced changes were shown in the long-term practitioners. 

A systems biology analysis of known interactions among the proteins produced by the affected genes revealed that pathways involved with energy metabolism, particularly the function of mitochondria, were upregulated during the relaxation response. Pathways controlled by activation of a protein called NF-κB—known to have a prominent role in inflammation, stress, trauma and cancer—were suppressed after relaxation response elicitation. The expression of genes involved in insulin pathways was also significantly altered.

“The combination of genomics and systems biology in this study provided great insight into the key molecules and physiological gene interaction networks that might be involved in relaying beneficial effects of relaxation response in healthy subjects,” said Manoj Bhasin, HMS assistant professor of medicine, co-lead author of the study, and co-director of the Beth Israel Deaconess Genomics, Proteomics, Bioinformatics and Systems Biology Center.

Bhasin noted that these insights should provide a framework for determining, on a genomic basis, whether the relaxation response will help alleviate symptoms of diseases triggered by stress. The work could also lead to developing biomarkers that may suggest how individual patients will respond to interventions.

Benson stressed that the long-term practitioners in this study elicited the relaxation response through many different techniques—various forms of meditation, yoga or prayer—but those differences were not reflected in the gene expression patterns.

“People have been engaging in these practices for thousands of years, and our finding of this unity of function on a basic-science, genomic level gives greater credibility to what some have called ‘new age medicine,’ ” he said.

“While this and our previous studies focused on healthy participants, we currently are studying how the genomic changes induced by mind/body interventions affect pathways involved in hypertension, inflammatory bowel disease and irritable bowel syndrome. We have also started a study—a collaborative undertaking between Dana-Farber Cancer Institute, Mass General and Beth Israel Deaconess—in patients with precursor forms of multiple myeloma, a condition known to involve activation of NF-κB pathways,” said Libermann, who is the director of the Beth Israel Deaconess Medical Center Genomics, Proteomics, Bioinformatics and Systems Biology Center.

(Source: hms.harvard.edu)

Filed under meditation stress response relaxation response anxiety inflammation metabolism neuroscience science

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