Research shows diabetes drug improves memory

An FDA-approved drug initially used to treat insulin resistance in diabetics has shown promise as a way to improve cognitive performance in some people with Alzheimer’s disease.

Working with genetically engineered mice designed to serve as models for Alzheimer’s, University of Texas Medical Branch at Galveston researchers found that treatment with the anti-insulin-resistance drug rosiglitazone enhanced learning and memory as well as normalized insulin resistance. The scientists believe that the drug produced the response by reducing the negative influence of Alzheimer’s on the behavior of a key brain-signaling molecule.

The molecule, called extracellular signal-regulated kinase (ERK), becomes hyperactive both in the brains of Alzheimer’s patients and in the mice at a disease stage corresponding to mild cognitive impairment in human Alzheimer’s. This excessive activity leads to improper synaptic transmission between neurons, interfering with learning and memory.

Rosiglitazone brings ERK back into line by activating what’s known as the peroxisome proliferator-activated receptor gamma (PPARγ) pathway, which interacts with genes that respond to both PPARγ and ERK.

“Using this drug appears to restore the neuronal signaling required for proper cognitive function,” said UTMB professor Larry Denner, the lead author of a paper describing this work now online (posted Nov. 21)  in the Journal of Neuroscience. “It gives us an opportunity to test several FDA-approved drugs to normalize insulin resistance in Alzheimer’s patients and possibly also enhance memory, and it also gives us a remarkable tool to use in animal models to understand the molecular mechanisms that underlie cognitive issues in Alzheimer’s.”

Experimental Drug Improves Memory in Mice with Multiple Sclerosis

Johns Hopkins researchers report the successful use of a form of MRI to identify what appears to be a key biochemical marker for cognitive impairment in the brains of people with multiple sclerosis (MS). In follow-up experiments on mice with a rodent form of MS, researchers were able to use an experimental compound to manipulate that same marker and dramatically improve learning and memory.

Half of people with MS experience learning and memory problems, for which there is no approved treatment, along with movement abnormalities that characterize the debilitating autoimmune disorder.

"We have a potentially novel treatment for cognitive impairment in MS, a devastating condition on the rise that affects at least 400,000 people in the United States," says study leader Adam I. Kaplin, M.D., Ph.D., an assistant professor of psychiatry and behavioral sciences and neurology at the Johns Hopkins University School of Medicine.

Kaplin cautions that the treatment has so far been used only in mouse models of MS and is years away from clinical trials in people.

Nevertheless, he says, the research, described in the Proceedings of the National Academy of Sciences published online on Nov. 19, has the potential to speed development of new drugs to treat cognitive impairment not only in MS patients, but also in patients with Alzheimer’s disease and other neurological conditions.

Swimming kids are smarter

Children who learn how to swim at a young age are reaching many developmental milestones earlier than the norm.

Researchers from the Griffith Institute for Educational Research surveyed parents of 7000 under-fives from Australia, New Zealand and the US over three years.

A further 180 children aged 3, 4 and 5 years have been involved in intensive testing, making it the world’s most comprehensive study into early-years swimming.

Lead researcher Professor Robyn Jorgensen says the study shows young children who participate in early-years swimming achieve a wide range of skills earlier than the normal population.

“Many of these skills are those that help young children into the transition into formal learning contexts such as pre-school or school.

“The research also found significant differences between the swimming cohort and non-swimmers regardless of socio-economic background.

“While the two higher socio-economic groups performed better than the lower two in testing, the four SES groups all performed better than the normal population.

The researchers also found there were no gender differences between the research cohort and the normal population.

As well as achieving physical milestones faster, children also scored significantly better in visual-motor skills such as cutting paper, colouring in and drawing lines and shapes, and many mathematically-related tasks. Their oral expression was also better as well as in the general areas of literacy and numeracy.

“Many of these skills are highly valuable in other learning environments and will be of considerable benefit for young children as they transition into pre-schools and school.”

Teenagers’ brains affected by preterm birth

New research at the University of Adelaide has demonstrated that teenagers born prematurely may suffer brain development problems that directly affect their memory and learning abilities.

The research, conducted by Dr Julia Pitcher and Dr Michael Ridding from the University of Adelaide’s Robinson Institute, shows reduced ‘plasticity’ in the brains of teenagers who were born preterm (at or before 37 weeks gestation).

The results of the research are published in the Journal of Neuroscience.

"Plasticity in the brain is vital for learning and memory throughout life," Dr Pitcher says. "It enables the brain to reorganise itself, responding to changes in environment, behaviour and stimuli by modifying the number and strength of connections between neurons and different brain areas. Plasticity is also important for recovery from brain damage.

"We know from past research that preterm-born children often experience motor, cognitive and learning difficulties. The growth of the brain is rapid between 20 and 37 weeks gestation, and being born even mildly preterm appears to subtly but significantly alter brain microstructure, neural connectivity and neurochemistry.

"However, the mechanisms that link this altered brain physiology with behavioural outcomes - such as memory and learning problems - have remained unknown," Dr Pitcher says.

Scripps Research Institute Scientists Uncover a New Pathway that Regulates Information Processing in the Brain

Scientists at The Scripps Research Institute (TSRI) have identified a new pathway that appears to play a major role in information processing in the brain. Their research also offers insight into how imbalances in this pathway could contribute to cognitive abnormalities in humans.

The study, published in the November 9, 2012 issue of the journal Cell, focuses on the actions of a protein called HDAC4. The researchers found that HDAC4 is critically involved in regulating genes essential for communication between neurons.

“We found that HDAC4 represses these genes, and its function in a given neuron is controlled by activity of other neurons forming a circuit,” said TSRI Assistant Professor Anton Maximov, senior investigator for the study.

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Wrens Teach Eggs to Sing

Mothers usually set about teaching their offspring the moment they’re born. But the females of one Australian bird can’t wait that long.

Superb fairy-wren (Malurus cyaneus) mothers sing to their unhatched eggs to teach the embryo inside a ‘password’ — a single unique note — which the nestlings must later incorporate into their begging calls if they want to get fed.

The trick allows fairy-wren parents to distinguish between their own offspring and those of the two cuckoo species that frequently invade their nests. The female birds also teach their mates the password.

Fairy-wrens were known to discriminate against cuckoo nestlings on the basis of their foreign begging calls, says Sonia Kleindorfer, an animal behaviorist at Flinders University in Adelaide, who led the work. But it wasn’t known that wren nestlings learned the passwords before hatching.

“It has never been shown before that there is actually learning in the embryo stages,” says Kleindorfer. The finding, published today in Current Biology, has the potential to open up new lines of enquiry into prenatal learning in systems other than parasite-host relationships and in other animals — it could occur anywhere where it’s a benefit, she adds.

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Rethinking reading: UI study breaks new ground in reading development research

Many educators have long believed that when words differ on only one sound, early readers can learn the rules of phonics by focusing on what is different between the words. This is thought to be a critical gateway to reading words and sentences.

But scientists at the University of Iowa are turning that thinking on its head. A recent study published in Developmental Psychology shows certain kinds of variation in words may help early readers learn better. When children see the same phonics regularities, embedded in words with more variation, they may learn these crucial early reading skills better. What might appear to make learning a more difficult task—learning about letter-sound relationships from words with more variation—actually leads to better learning.

Doctoral student Keith Apfelbaum and associate professors Bob McMurray and Eliot Hazeltine of the Department of Psychology in the UI College of Liberal Arts and Sciences (CLAS) studied 224 first-grade students in the West Des Moines, Iowa school system over a period of three months. The group used a version of an online supplementary curriculum called Access Code.

Access Code was developed by Foundations in Learning, a company founded by Carolyn Brown and Jerry Zimmermann. Brown and Zimmermann earned their doctorates from and are now adjunct faculty in the Department of Communication Sciences and Disorders, also in CLAS. Based on the Varied Practice Model, which helps children master early reading skills like phonics, the research team used Access Code to conduct the study directly in the classroom.

To bee an art critic, choosing between Picasso and Monet

Honeybees are also discerning art critics, according to scientists from UQ’s Queensland Brain Institute, the UQ School of Psychology and the Federal University of Sao Carlos, Brazil.

The study, published in the Journal of Comparative Physiology A, found honeybees had remarkable visual learning and discrimination abilities that extended beyond simple colours, shapes or patterns.

QBI researcher Dr Judith Reinhard said honeybees had a highly developed capacity for processing complex visual information, and could distinguish landscape scenes, types of flowers, and even human faces.

“This suggests that in spite of their small brain, honeybees have a highly developed capacity for processing complex visual information, comparable in many respects to vertebrates,” she said.

Dr Reinhard and her team investigated whether this capacity extended to complex images that humans distinguish on the basis of artistic style, including Impressionist paintings by Monet and Cubist paintings by Picasso.

“We were able to show that honeybees learned to simultaneously discriminate between five different Monet and Picasso paintings, and that they did not rely on luminance, colour, or spatial frequency information,” she said.

When presented with novel paintings of the same style, the bees demonstrated an ability to generalise, suggesting they could differentiate Monet from Picasso by extracting and learning the characteristic visual information inherent in each style.

“Our study suggests that discrimination of artistic styles is not a higher cognitive function that is unique to humans, but simply due to the capacity of animals – from insects to humans – to extract and categorise the visual characteristics of complex images,” Dr Reinhard said.

Unique protein bond enables learning and memory

Two proteins have a unique bond that enables brain receptors essential to learning and memory to not only get and stay where they’re needed, but to be hauled off when they aren’t, researchers say.

NMDA receptors increase the activity and communication of brain cells and are strategically placed, much like a welcome center, at the receiving end of the communication highway connecting two cells. They also are targets in brain-degenerating conditions such as Alzheimer’s and Parkinson’s.

In a true cradle-to-grave relationship, researchers have found the scaffolding protein, SAP102, which helps stabilize the receptor on the cell surface, binds with a subunit of the NMDA receptor called GluN2B at two sites, said Dr. Bo-Shiun Chen, neuroscientist at the Medical College of Georgia at Georgia Health Sciences University.

While one binding site is the norm, these proteins have one that’s stronger than the other. When it’s time for the normal receptor turnover, the stronger bond releases and the lesser one shuttles the receptor inside the cell for degradation or recycling.

“One binding site is involved in stabilizing the receptor on the cell surface and the other is important in removing the receptor. We think it’s a paradigm shift; we’ve never thought about the same scaffolding protein having two roles,” said Chen, corresponding author of the study in the journal Cell Reports.

Ping-pong-playing robot learns to play like a person

A ROBOT that learns to play ping-pong from humans and improves as it competes against them could be the best robotic table-tennis challenger the world has seen.

Katharina Muelling and colleagues at the Technical University of Darmstadt in Germany suspended a robotic arm from the ceiling and equipped it with a camera that watches the playing area. Then Muelling physically guided the arm through different shots to return incoming balls.

The arm was then left to draw on its training to return balls hit by a human opponent. When the ball was in a position it had not seen before, the arm used its library of shots to improvise new ones. After an hour of unassisted practise, the system successfully returned 88 per cent of shots.

Other robots have played table tennis in the past, but none have used human demonstration to learn the game. Ales Ude of the Jožef Stefan Institute in Slovenia says that doing so allows robots to play more like people.

The work, which will be presented at an AAAI symposium in Arlington, Virginia, next month, is part of a broader goal to develop robots that can do a range of tasks after being guided by their owners, Muelling says.