Posts tagged children

Posts tagged children
Pollution in many cities threatens the brain development in children.

Findings by University of Montana Professor Dr. Lilian Calderón-Garcidueñas, MA, MD, Ph.D., and her team of researchers reveal that children living in megacities are at increased risk for brain inflammation and neurodegenerative changes, including Alzheimer’s or Parkinson’s disease.
Calderón-Garcidueñas’ findings are detailed in a paper titled “Air pollution and children: Neural and tight junction antibodies and combustion metals, the role of barrier breakdown and brain immunity in neurodegeneration,” which can be found online at http://iospress.metapress.com/content/xx6582688105j48h/.
The study found when air particulate matter and their components such as metals are inhaled or swallowed, they pass through damaged barriers, including respiratory, gastrointestinal and the blood-brain barriers and can result in long-lasting harmful effects.
Calderón-Garcidueñas and her team compared 58 serum and cerebrospinal fluid samples from a control group living in a low-pollution city and matched them by age, gender, socioeconomic status, education and education levels achieved by their parents to 81 children living in Mexico City.
The results found that the children living in Mexico City had significantly higher serum and cerebrospinal fluid levels of autoantibodies against key tight-junction and neural proteins, as well as combustion-related metals.
“We asked why a clinically healthy kid is making autoantibodies against their own brain components,” Calderón-Garcidueñas said. “That is indicative of damage to barriers that keep antigens and neurotoxins away from the brain. Brain autoantibodies are one of the features in the brains of people who have neuroinflammatory diseases like multiple sclerosis.”
The issue is important and relevant for one reason, she explained. The breakdown of the blood-brain barrier and the presence of autoantibodies to important brain proteins will contribute to the neuroinflammation observed in urban children and raises the question of what role air pollution plays in a 400 percent increase of MS cases in Mexico City, making it one of the main diagnoses for neurology referrals.
Calderón-Garcidueñas points out that there is a need for a longitudinal follow-up study to determine if there is a relationship between the cognition deficits and brain MRI alterations previously reported in Mexico City children, and their autoimmune responses. But what is clear is that the kids are suffering from immune dysregulation.
Once there is a breakdown in the blood-brain barrier, not only will particulate matter enter the body but it also opens the door to harmful neurotoxins, bacteria and viruses.
“The barriers are there for a reason,” she explains. “They are there to protect you, but once they are broken the expected results are not good.”
The results of constant exposure to air pollution and the constant damage to all barriers eventually result in significant consequences later in life. She explains that the autoimmune responses are potentially contributing to the neuroinflammatory and Alzheimer’s and Parkinson’s pathology they are observing in young urban children.
While the study focused on children living in Mexico City, others living in cities where there are alarming levels of air pollution such as Los Angeles, Philadelphia-Wilmington, New York City, Salt Lake City, Chicago, Tokyo, Mumbai, New Delhi or Shanghai, among others, also face major health risks. In the U.S. alone, 200 million people live in areas where pollutants such as ozone and fine particulate matter exceed the standards.
“Investing in defining the central nervous system pathology associated with exposure to air pollutants in children is of pressing importance for public health,” Calderón-Garcidueñas said.
The full article is scheduled to be published in Volume 43, Issue 3 of the Journal of Alzheimer’s Disease and will appear online at http://www.j-alz.com in December with a 2015 copyright.
(Source: news.umt.edu)
A new study suggests that colds and other minor infections may temporarily increase stroke risk in children. The study found that the risk of stroke was increased only within a three-day period between a child’s visit to the doctor for signs of infection and having the stroke.

The study was led by researchers at UCSF Benioff Children’s Hospital San Francisco in collaboration with the Kaiser Permanente Division of Research.
“These findings suggest that infection has a powerful but short-lived effect on stroke risk,” said senior author Heather Fullerton, MD, a pediatric vascular neurologist and medical director of the Pediatric Brain Center at UCSF Benioff Children’s Hospital San Francisco.
“We’ve seen this increase in stroke risk from infection in adults, but until now, an association has not been studied in children.”
Strokes are extremely rare in children, affecting just five out of 100,000 kids per year. “The infections are acting as a trigger in children who are likely predisposed to stroke,” said Fullerton. “Infection prevention is key for kids who are at risk for stroke, and we should make sure those kids are getting vaccinated against whatever infections – such as flu - that they can.”
The study appears in the August 20, 2014, online issue of Neurology.
In the study, researchers reviewed a Kaiser Permanente database of 2.5 million children and identified 102 children who had an ischemic stroke – a stroke that occurs as a result of an obstruction within a blood vessel supplying blood to the brain - without a major infection such as meningitis or sepsis. The researchers then compared them with 306 children without stroke. Medical records for the group of children who had a stroke were reviewed for minor infections up to two years before their strokes.
The study found that the risk of stroke was increased only within a three-day time frame, which the researchers say represents a period of acute inflammation. As an infection resolves, the inflammation decreases, as does the stroke risk.
A total of 10 of the 102 children who had a stroke had a doctor visit for an infection within three days of the stroke, or 9.8 percent, while only two of the 306 control participants, or 0.7 percent, had an infection during the same time period.
The children who had strokes were 12 times more likely to have had an infection within the previous three days than the children without strokes. The total number of infections over a two-year period was not associated with increased stroke risk. About 80 percent of the minor infections identified by the researchers were upper respiratory.
“It’s important the public does the things we can to prevent infection, like vaccinations, good hand washing and covering your mouth when you sneeze in order to protect all children, but it’s especially important to help prevent stroke in someone who is otherwise predisposed,” said Fullerton.
(Source: ucsf.edu)
In a world-first, a newly published study has captured in detail the brain electrical activity in children as they emerge from anaesthesia, shedding light on why some are distressed and agitated when they wake up.

Researchers from Swinburne University of Technology together with colleagues from the Murdoch Childrens Research Institute (MCRI) were able to collect electroencephalography (EEG) data on children who exhibited emergence delirium.
Emergence delirium is a major risk associated with anaesthesia in children and occurs when patients wake up from anaesthesia in a delirious and disassociated state.
Swinburne Professor David Liley said PhD student Jessica Martin and staff at MCRI were able to record, with unprecedented fidelity, brain electrical activity from 60 children aged 5-15 years who emerged from anaesthesia some of whom went on to exhibit emergence delirium.
“This clinical phenomenon is prevalent in children aged six and under, with an estimated 10-30% exhibiting emergence delirium,” said Professor Liley.
Researchers found that the brain activity recorded just after stopping sevoflurane (a form of gas anaesthesia) in children exhibiting emergence delirium was substantially different to those children who woke up peacefully.
Associate Professor Andrew Davidson from MCRI said they discovered that children who wake up suddenly from a deeper plane of anaesthetic are more likely to develop the delirium.
“In contrast, the children who develop sleep like patterns on their EEG before they wake up are more likely to wake up peacefully.”
“Intriguingly, emergence delirium looks very much like the more severe form of night terror, which occurs when some pre-school children are disturbed during deep sleep.
“Our study suggests the EEG signatures and the mechanisms may indeed be similar between night terror and emergence delirium.
“Allowing children to wake up in a quiet and undisturbed environment should increase the likelihood that they go into a light sleep-like state after the anaesthetic and then wake up peacefully,” said Associate Professor Davidson.
The findings will have significant implications in both predicting those children who will go on to develop emergence delirium, as well as helping medical professionals better understand its causes in both children and adults.
The study, Alterations in the Functional Connectivity of Frontal Lobe Networks Preceding Emergence Delirium in Children, will appear in the October issue of the high profile clinical journal, Anesthesiology and is electronically available ahead of print.
(Source: swinburne.edu.au)
A little video gaming ‘produces well-adjusted children’
Playing video games for a short period each day could have a small but positive impact on child development, a study by Oxford University suggests.
Scientists found young people who spent less than an hour a day engaged in video games were better adjusted than those who did not play at all.
But children who used consoles for more than three hours reported lower satisfaction with their lives overall.
The research is published in the journal Pediatrics.
Bad maths grades, poor participation in class, no interest in arithmetic. Preterm children often suffer from dyscalculia – at least according to some scientific studies. A misunderstanding, claims developmental psychologist Dr Julia Jäkel, who has been studying the performance of preterm children.
Thanks to modern medicine, the percentage of preterm survivors is constantly increasing. On the cognitive level, these children frequently have long-term problems such as poor arithmetic skills and difficulty concentrating. For a long time, research focused on high-risk children, born before 32 weeks gestational age or with less than 1,500 gram. Current studies from the most recent years, however, show that this approach is too short-sighted.
Dr Julia Jäkel from the Department of Developmental Psychology has analysed cognitive abilities of children born between 23 and 41 weeks gestation. In doing so, she covered the entire spectrum, ranging from extremely preterm to healthy term born infants. For this purpose, she used data of the Bavarian Longitudinal Study, which has been following a birth cohort from the late 80s until today. “Having access to such a comprehensive long-term study is a dream come true for every developmental psychologist,” says the Bochum researcher. Over the course of the study, all children underwent a whole battery of tests that assessed their cognitive and educational abilities, and their parents were interviewed in depth.
The RUB researcher has so far mainly focused on data collected at preschool and early school age. For different test tasks, she assessed their cognitive workload, a criterion for the complexity of a given task. The data showed that preterm children had greater difficulties with tasks that demanded higher working memory resources. Moreover, results revealed that not only high-risk children had significant difficulties. On average, the more preterm a child had been born, the poorer were his or her abilities to solve complex tasks.
But what exactly is the nature of these difficulties? It has been frequently suggested that preterm children suffer from dyscalculia. A phenomenon that Julia Jäkel examined more closely. “Mathematical deficiencies, maths learning disorder, dyscalculia, innumeracy – these terms’ definitions vary slightly,” she explains, but there are no standardised, internationally consistent diagnostic criteria. In order to assess specific maths deficiencies, children in Germany are assessed with a number of tests. If their results fall below a certain cut off value in maths while their cognitive skills (IQ) are in the normal range, they are diagnosed with “maths learning disorder” or “dyscalculia”.
“The problem with preterm children, however, is that they often have general cognitive deficits,” Julia Jäkel points out. “According to current criteria, these children can’t be diagnosed.” Together with Dieter Wolke from the University of Warwick, UK, she compared different diagnostic criteria for dyscalculia in her analysis. The aim of the study was to identify specific maths deficiencies in preterm children that were independent of general cognitive impairments. With surprising results: “There is no specific maths deficit in preterm children if their general IQ is factored in,” says the researcher.
This means that preterm children do not suffer from dyscalculia more often than term children. However, they often have maths difficulties and these may not be recognized. This is because the current criteria make it impossible to diagnose dyscalculia if a child also has general cognitive deficits. Thus, these children do not receive specific help in maths although they may be in urgent need. “We need reliable and consistent diagnostic criteria,” demands Julia Jäkel. “And we’ve got to find ways to actually deliver support in schools.”
Together with her British team, the psychologist compared the results of the Bavarian Longitudinal Study with “EPICure” data, a similar study that commenced in the UK in the 1990s, following a cohort of extremely preterm children. The researchers focus on mathematical and educational performance. British preterm children had similar cognitive and basic numerical skills as German preterm children. In terms of maths achievement, however, they showed significantly better results. “We explain this with the fact that, unlike in Germany, in the UK it has not been possible for children to delay school entry,” explains Julia Jäkel. “In addition, special schools are attended by only a small percentage of extremely disabled children. All other children are integrated into normal classes in regular schools and receive targeted support there.”
The developmental psychologist has already demonstrated that assistance at primary-school age can really make a difference. Parents who support their preterm children with sensitive scaffolding can compensate the negative cognitive effects of preterm birth. It is helpful, for example, if parents give their children appropriate feedback to homework tasks and suggest potential solutions, rather than solving the tasks for the child. However, Julia Jäkel believes that a lot of research is yet to be done as far as intervention is concerned: “A large percentage of parents is very dedicated and has resources to help their children,” she says. “But research has not yet produced anything that would ensure successful results in the long-term.” Together with colleagues from the university hospital in Essen, the RUB researcher plans to investigate the benefits of computer-aided working memory training for preterm children’s school success, which has already been successfully applied on an international level.
It would also be helpful if findings from related disciplines, such as developmental psychology, educational research, and neonatal medicine were better integrated. This is, for example, because neonatal medical treatment can significantly affect later cognitive performance. Together with her interdisciplinary team, Julia Jäkel used a comprehensive model to analyse to what extent different neonatal medical indicators affect cognitive development at age 20 months, attention abilities at age six, and maths abilities at age eight years. In her analyses, she factored in child sex and socio-economic status.
Results showed that neonatal medical variables, e.g., the duration of mechanical ventilation, predicted cognitive abilities at age 20 months. Both factors together predicted attention regulation at age six years. And all those precursors, in turn, affected long-term general maths abilities.
Subsequently, Julia Jäkel analysed the data once again from a different perspective, in order to predict specific maths skills that were independent of the child’s IQ. In that model, only two variables had direct impact: the duration of mechanical ventilation and hospitalisation after birth. In the 1980s, when children participating in the Bavarian Longitudinal Study were born, German doctors often used invasive ventilation methods. Today, less invasive methods are available, but to what extent they may affect long-term cognitive performance has not yet been investigated.
“Both too high and too low oxygen concentrations are harmful to brain development,” explains Julia Jäkel. “The neonatologist in charge is faced with the great challenge of determining the right dose for each infant, depending on individually changing situations.” This is why it is so important to integrate psychological models with neonatal intensive care research. The joint objective is to offer preterm children the chance of a successful school career, high quality of life and social participation.
The secrets of children’s chatter: research shows boys and girls learn language differently
Experts believe language uses both a mental dictionary and a mental grammar. The mental ‘dictionary’ stores sounds, words and common phrases, while mental ‘grammar’ involves the real-time composition of longer words and sentences. For example, making a longer word ‘walked’ from a smaller one ‘walk’.
However, most research into understanding how these processes work has been carried out with adults.
“Most researchers agree that the way we use language in our minds involves both storing and real-time composition,” said lead researcher Dr Cristina Dye, a specialist in child language development at Newcastle University. “But a lot of the specifics about how this happens are unclear, such as identifying exactly which parts of language are stored and which are composed.
“Most research on this topic has concentrated on adults and we wanted to see if studying children could help us learn more about these processes.”
A test based around 29 irregular verbs and 29 regular verbs was presented to the young participants. Only verbs which would be known by eight-year-olds were used.
They were presented with two sentences. One featured the verb in the context of the sentence, with the second sentence containing a blank to allow the children to produce the past-tense form. For example: Every day I walk to school. Just like every day, yesterday I ____ to school.
The children were asked to produce the missing word as quickly and as accurately as possible and their response times were recorded. The results were then analysed to discover which words were stored or created in real-time.
Results showed girls were more likely to memorise words and phrases – use their mental dictionary - while boys used mental grammar - i.e assembled these from smaller parts - more often.
The findings could have implications in the way youngsters are taught in the classroom, believes Dr Dye, who is based in the Centre for Research in Linguistics and Language Sciences.
She said: “What we found as we carried out the study was that girls were far more likely to remember forms like ‘walked’ while boys relied much more on their mental grammar to compose ‘walked’ from ‘walk’ and ‘ed’. This fits in with previous research which has identified differences between the sexes when it comes to memorising facts and events, where girls also seem to have an advantage compared to boys.
“One interesting aside to this is that as girls often outperform boys at school, it could be that the curriculum is put together in a way which benefits the way girls learn. It may be worth further investigation to see if this is the case and if so, is there a way lessons could be changed so boys can get the most out of them too.”
Paper: Children’s Computation of Complex Linguistic Forms: A study of Frequency and Imageability Effects
(Image: Getty Images)
The amygdala is a key “fear center” in the brain. Alterations in the development of the amygdala during childhood may have an important influence on the development of anxiety problems, reports a new study in the current issue of Biological Psychiatry.

Researchers at the Stanford University School of Medicine recruited 76 children, 7 to 9 years of age, a period when anxiety-related traits and symptoms can first be reliably identified. The children’s parents completed assessments designed to measure the anxiety levels of the children, and the children then underwent non-invasive magnetic resonance imaging (MRI) scans of brain structure and function.
The researchers found that children with high levels of anxiety had enlarged amygdala volume and increased connectivity with other brain regions responsible for attention, emotion perception, and regulation, compared to children with low levels of anxiety. They also developed an equation that reliably predicted the children’s anxiety level from the MRI measurements of amygdala volume and amygdala functional connectivity.
The most affected region was the basolateral portion of the amygdala, a subregion of the amygdala implicated in fear learning and the processing of emotion-related information.
“It is a bit surprising that alterations to the structure and connectivity of the amygdala were so significant in children with higher levels of anxiety, given both the young age of the children and the fact that their anxiety levels were too low to be observed clinically,” commented Dr. Shaozheng Qin, first author on this study.
Dr. John Krystal, Editor of Biological Psychiatry, commented, “It is critical that we move from these interesting cross-sectional observations to longitudinal studies, so that we can separate the extent to which larger and better connected amygdalae are risk factors or consequences of increased childhood anxiety.”
“However, our study represents an important step in characterizing altered brain systems and developing predictive biomarkers in the identification for young children at risk for anxiety disorders,” Qin added. “Understanding the influence of childhood anxiety on specific amygdala circuits, as identified in our study, will provide important new insights into the neurodevelopmental origins of anxiety in humans.”
(Source: elsevier.com)

Gene mutation discovery could explain brain disorders in children
Researchers have discovered that mutations in one of the brain’s key genes could be responsible for impaired mental function in children born with an intellectual disability.
The research, published today in the journal, Human Molecular Genetics, proves that the gene, TUBB5, is essential for a healthy functioning brain.
It’s estimated that intellectual disability affects up to four per cent of people worldwide, and two per cent of all Australians. One of the ways in which intellectual disability occurs is through genetic mutations, which cause problems with normal fetal brain development.
During fetal brain development, TUBB5 is essential for the proper placement and wiring of new neurons. When the gene is mutated, the brain, which sends and receives messages to the rest of the body, is impaired.
Lead researcher, Dr Julian Heng, from the Australian Regenerative Medicine Institute (ARMI) at Monash University, said genetic mutations to TUBB5 could be responsible for a range of intellectual disabilities. It could also affect the development of basic motor skills such as walking.
“TUBB5 works like a type of scaffolding inside neurons, enabling them to shape their connections to other neurons, so it’s essential for healthy brain development. If the scaffolding is faulty, in this case if TUBB5 mutates, it can have serious consequences,” Dr Heng said.
These new findings build on the team’s collaborative work with researchers in Austria, which led to the discovery of TUBB5 mutations in human brain disorders in 2012. By looking at just three unrelated patients with microcephaly, a rare brain disease in children, the team found striking similarities – each had a mutation to TUBB5. The team also provided the first evidence that the TUBB5 mutations were responsible for each patient’s disorder.
Dr Heng said the research could have important implications, not only for intellectual disabilities but also for a wide range of developmental disorders.
“Learning more about the TUBB5 gene and its mutations could reveal how it shapes the connections of neurons in normal and diseased brain states.
“We’re just at the beginning of this work but if we can understand why and how mutations occur to TUBB5, we may even be able to repair these mutations. In the future, we believe this work will enable us to develop new therapies to transform people’s lives,” Dr Heng said.
The work may potentially lead to new information about the causes and possible treatments for other brain developmental syndromes, including autism, a condition that affects as many as 1 in 160 children.
Dr Heng said that because TUBB5 belongs to a family of genes which produce the scaffolding in neurons, it means that there is scope for further study into its impact.
“By learning what these scaffolding proteins do to help neurons make brain circuits, we might be able to pinpoint the underlying causes of a wide range of brain disorders in children, and develop more targeted treatments,” Dr Heng said.
Scientists believe that in the future this knowledge, combined with regenerative medicine techniques, could also aid the replacement of neurons in times of brain injury or disease.
The next phase of the research will be to develop a working model to better understand how TUBB5 can be targeted for gene therapy.
Study shows anaesthesia may harm memory
General anaesthesia before the age of one may impair memory later in childhood, and the effects may possibly be lifelong, a study said Monday.
This was the conclusion of scientists who compared the recollection skills of two groups of children — some who had undergone anaesthesia in infancy and others who had not.
The children, aged six to 11 and divided into two groups of 28 each, were tested over a period of 10 months for their ability to recollect specific drawings and details therein.
The children who had been anaesthetised as babies had about 28 per cent less recollection on average than their peers, and scored 20 per cent lower in tests that assessed how much detail they could remember about the drawings.
"The children did not differ in tests measuring intelligence or behaviour, but those who had received anaesthesia had significantly lower recollection scores," said a media summary provided by the journal Neuropsychopharmacology, which published the results.
Outgrowing emotional egocentricity
Children are more egocentric than adults. Scientists from the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig have demonstrated for the first time that children are also worse at putting themselves in other people’s emotional shoes. According to the researchers, the supramarginal gyrus region of the brain must be sufficiently developed in children for them to be able to overcome their egocentric take on the world.
When little Philip rejoices at winning the prize in a game, it is almost impossible for him to understand that his best friend Tom, who has just lost, is not as jubilant. The opposite also applies. “Children are simply more egocentric,” says Nikolaus Steinbeis, a researcher at the Leipzig-based Max Planck Institute, summing up the general hypothesis.
Egocentrism refers to the inability to differentiate between one’s own point of view and that of other people. Egocentric people consider themselves to be the centre of all activity and assess all events and circumstances from this perspective. They project their own ideas, fears and desires onto the environment and others.
Up to now, all that the research in this area had to offer was a few theoretical ideas and studies on the development of cognitive perspective-taking. The question concerning egocentrism in connection with people’s emotional states and the development of this phenomenon over the course of childhood had been largely ignored. “We currently know very little about how emotional egocentrism is expressed in childhood and about the neuronal and cognitive processes on which this is based,” explains Steinbeis.
In order to compare the emotional states of different age groups, Steinbeis used an innovative game involving monetary rewards and punishments. “Earlier studies have shown that similarly strong emotional states can be triggered in both children and adults using such rewards and punishments. Children take as much delight as adults in monetary rewards and they are just as frustrated by losses,” he says.
During the game, two people competed against each other without, however, being able to see each other. Equipped with a computer screen and keyboard, the test subjects were asked to demonstrate their reaction speed. The participants were informed by the screen as to whether they or their opponents could rejoice in victory or despair in defeat. They were then asked to estimate the emotions experienced by their opponents. Of principal interest was how strongly the players’ own results influenced their assessments of their opponents’ emotional state. For example, if, due to their own status as a winner, a participant assessed their counterpart as being happy, despite the fact that the latter had just lost the game, this indicated that the winner was egocentrically projecting their own state onto the opponent.
The results of the study reveal that adults found it easy to overcome this tendency, whereas children between the ages of 6 and 13 tended to be guided by their own emotions when assessing those of others. The ability to assess the emotions of our counterparts independently of our own emotional state improves with age. “In general, the older a child is, the better he or she will be able to put itself in the emotional position of another person,” says Steinbeis, explaining the study findings.
In addition, the scientists measured the activity of different regions of the brain in MRI scanners and discovered a region that plays a crucial role in our ability to overcome our own feelings. The right supramarginal gyrus is a region of the temporoparietal junction, which is generally necessary for overcoming one’s own point of view. It is strongly linked with other brain regions like the anterior insula, which is exclusively responsible for enabling us to identify with other people’s emotional states. “This means that, with the right supramarginal gyrus, we have located a region which mainly functions in enabling us to overcome our own feelings,” says Steinbeis. Moreover, the scientists established that, with increasing age, the cortical thickness of the nerve fibres in this area declines. This suggests that the nerve fibres are more active as we get older.
Emotional egocentrism plays a major role in many conflicts, as the inability to overcome egocentric thinking leads to inappropriate social behaviour. People affected by this condition experience rejection, which has been shown to have a negative impact on health and development. Scientists would therefore like to understand the reasons for socially detrimental behaviour and develop options for targeted intervention.