Posts tagged brain activity
Articles and news from the latest research reports.
Dad’s Brain Becomes More ‘Maternal’ When He’s Primary Caregiver
Fathers who spend more time taking care of their newborn child undergo changes in brain activity that make them more apt to fret about their baby’s safety, a new study shows.
(Image: Shutterstock)
In particular, fathers who are the primary caregiver experience an increase in activity in their amygdala and other emotional-processing systems, causing them to experience parental emotions similar to those typically experienced by mothers, the researchers noted.
The findings suggest there is a neural network in the brain dedicated to parenting, and that the network responds to changes in parental roles, said study senior author Ruth Feldman, a researcher in the department of psychology and the Gonda Brain Sciences Center at Bar-Ilan University in Israel.
"Pregnancy, childbirth and lactation are very powerful primers in women to worry about their child’s survival," said Feldman, who also serves as an adjunct professor at the Yale Child Study Center at Yale University. "Fathers have the capacity to do it as well as mothers, but they need daily caregiving activities to ignite that mothering network."
First Non-Study Site to Implant Device for Stopping Uncontrolled Seizures
NYU Langone Medical Center last month became the first hospital outside of a clinical trial site to implant a pacemaker-like device in the brain that may be a game-changer for patients with epilepsy.
The device, called the RNS System, was implanted April 17, 2014 in a patient with seizures that previously could not be controlled with medication, or intractable epilepsy, by Werner Doyle, MD, an associate professor in the Department of Neurosurgery at NYU Langone. The patient has recovered completely from the surgery.
The first-of-its-kind device is similar to an implantable cardioverter-defibrillator (ICD), which delivers electrical pulses to the heart to prompt it to beat a normal rhythm and provides a new alternative treatment to vagus nerve stimulation and surgical removal of the focus site – parts in the brain where the seizures originate — for people with intractable epilepsy.
Prior to last month’s surgery, the only implants of the seizure-reducing medical device took place at U.S. medical centers that had previously researched the device’s effectiveness and safety, making NYU Langone the first non-study hospital in the U.S. and New York metropolitan area to offer the RNS System to patients.
"Medically intractable epilepsy is often a debilitating disorder that puts sufferers at risk from sudden loss of consciousness and uncontrolled movements. It stigmatizes patients and restricts their independence," said Dr. Doyle. "Epilepsy surgery is an important therapeutic option for patients, which can significantly or completely control their seizures and return their lives to normal. The RNS device improves our ability to control seizures with surgery and now offers patients who may not have been surgical candidates in the past a surgical option."
According to the Centers for Disease Control and Prevention, about 2.3 million Americans suffer from epilepsy, with about one in 26 people expected to be diagnosed in their lifetimes. Approximately one-third of patients do not respond to medications and face major challenges with daily living. Uncontrolled seizures may interfere with normal activities such as working, going to school and driving. Patients also face increased risk for anxiety, depression, injury, brain damage, and in rare cases, death.
The RNS System, manufactured by NeuroPace Inc. of Mountain View, Calif., is a responsive stimulation device that’s implanted in the skull along with brain electrodes to detect abnormal electrical activity in the brain associated with seizures. After two or more weeks of recording the activity, doctors program the device to specifically respond to these abnormal signals by delivering imperceptible electrical pulses to the brain that normalize the activity. The device essentially “reboots” the portion of the brain where the seizure is originating, thereby effectively interrupting the abnormal electrical activity before it spreads or causes its unwanted effects.
The RNS System received pre-market approval from the Food and Drug Administration in November 2013 to treat patients’ seizures that have not been controlled by two or more antiepileptic medications.
In clinical trials performed at medical centers across the U.S., including at Saint Barnabas Medical Center in New Jersey by Dr. Doyle and Orrin Devinsky, MD, director of the Comprehensive Epilepsy Center at NYU Langone, 55 percent of patients experienced a 50 percent or greater reduction in seizures two years post implantation.
"The RNS System represents one of the most important and innovative therapies to treat people with epilepsy," says Dr. Devinsky. "This new surgical therapy uses information to target and shut down points in the brain where seizures start without removing tissue, providing a novel option for patients with uncontrolled seizures."
For more information:
Neurology, Morrell et al, 2011.
Neuroscientists discover adaptation mechanisms of the brain when perceiving letters of the alphabet
The headlights – two eyes, the radiator cowling – a smiling mouth: This is how our brain sometimes creates a face out of a car front. The same happens with other objects: in house facades, trees or stones – a “human face” can often be detected as well. Prof. Dr. Gyula Kovács from Friedrich Schiller University Jena (Germany) knows the reason why. “Faces are of tremendous importance for human beings,” the neuroscientist explains. That’s why in the course of the evolution our visual perception has specialized in the recognition of faces in particular. “This sometimes even goes as far as us recognizing faces when there are none at all.”
Until now the researchers assumed that this phenomenon is an exception that can only be applied to faces. But, as Prof. Kovács and his colleague Mareike Grotheer were able to point out in a new study: these distinct adaptation mechanisms are not only restricted to the perception of faces. In the The Journal of Neuroscience the Jena researchers have proved that the effect can also occur in the perception of letters.
Altruism/egoism: a question of points of view
Different brain structures are at the basis of these behaviours
Sociality, cooperation and “prosocial” behaviours are the foundation of human society (and of the extraordinary development of our brain) and yet, taken individually, people often show huge variation in terms of altruism/egoism, both among individuals and in the same individual at different moments in time. What causes these differences in behaviour? An answer may be found by observing the activity of the brain, as was done by a group of researchers from SISSA in Trieste (in collaboration with the Human-Computer Interaction Lab, HCI lab, of the University of Udine). The brain circuits that are activated suggest that each of the two behaviour types corresponds to a cognitive analysis that emphasizes different aspects of the same situation.
It depends on how we experience the situation, or rather, on how our brain decides to experience it: when in a situation of need, will we adopt an altruistic behaviour, at the cost of putting our lives at risk, or will we behave selfishly? People make extremely variable decisions in such cases: some have a tendency to be always altruistic or always selfish, and some change their behaviour depending on the situation. What happens in a person’s mind when he/she decides to adopt one style rather than the other? This is the question that Giorgia Silani, a neuroscientist at SISSA, and colleagues addressed in a study just published in NeuroImage: “Even though prosocial behaviours are crucial to human society, and most probably helped to mould our cognitive system, we don’t always behave altruistically,” explains Silani. “We wanted to see what changes occur in our brain between one type of behaviour and the other”.
Silani and colleagues used a brain imaging technique which allows investigators to isolate the most active brain structures during a task. “In our experiments the participants were immersed in a virtual reality scenario in which they had to decide whether to help someone, and potentially put their own lives in danger, or save themselves without considering the other person” explains Silani. One innovative feature of the study is in fact the possibility of creating “ecological” experimental conditions, that is, as close as possible to a real situation.
“Traditionally, studies in this field used “games” in which participants had to allocate monetary gains, but many researchers including ourselves believe that these conditions are too artificial and tell us very little about altruism and egoism in daily life. However, obvious ethical constraints make it impossible to design realistic field experiments. Virtual reality has proved to be a good compromise that preserves the authenticity of the situation without putting anyone in danger”.
Silani and colleagues were able to see that in the brain of the tested subjects significantly different brain circuits are activated during the two types of behaviour (selfish/altruistic). In the first case the most active area was the “salience network” (anterior insula, anterior cingulate cortex) whereas the most intensely involved structures in altruistic behaviour were the prefrontal cortex and the temporo-parietal junction.
“The salience network, which serves to increase the “conspicuity” of stimuli for the cognitive system, could make the dangers of the situation more apparent to the subject, leading the individual to behave in a selfish manner. Conversely, the areas that are most active when a subject decides to behave altruistically are the ones that the scientific literature commonly associates with the ability to take another person’s point of view, which would therefore make the subject more empathic and willing to act for the benefit of others”.
“Ours is the first study to measure neurophysiological data during decision-making in life-threatening situations” concludes Silani. In addition to Silani, who coordinated the study, the SISSA team also includes Marco Zanon, first author, and Giovanni Novembre, whereas HCI Lab investigators are Nicola Zangrando and Luca Chittaro.
Revealing Rembrandt
The power and significance of artwork in shaping human cognition is self-evident. The starting point for our empirical investigations is the view that the task of neuroscience is to integrate itself with other forms of knowledge, rather than to seek to supplant them. In our recent work, we examined a particular aspect of the appreciation of artwork using present-day functional magnetic resonance imaging (fMRI). Our results emphasized the continuity between viewing artwork and other human cognitive activities. We also showed that appreciation of a particular aspect of artwork, namely authenticity, depends upon the co-ordinated activity between the brain regions involved in multiple decision making and those responsible for processing visual information. The findings about brain function probably have no specific consequences for understanding how people respond to the art of Rembrandt in comparison with their response to other artworks. However, the use of images of Rembrandt’s portraits, his most intimate and personal works, clearly had a significant impact upon our viewers, even though they have been spatially confined to the interior of an MRI scanner at the time of viewing. Neuroscientific studies of humans viewing artwork have the capacity to reveal the diversity of human cognitive responses that may be induced by external advice or context as people view artwork in a variety of frameworks and settings.
(Figure 1: Correspondence between the activity of the medial prefrontal cortex and study results in the second year versus the first year. Horizontal axis shows the degree of activity in the medial prefrontal cortex of various students; vertical axis shows performance improvement in the second academic year compared with the first.)
How the brain builds on prior knowledge
It is easier to learn something new if you can link it to something you already know. A specific part of the brain appears to be involved in this process: the medial prefrontal cortex. The Journal of Cognitive Neuroscience has published these findings, from research by neuroscientists at Radboud university medical center and Radboud University, as an Early Access paper. The findings further enhance our understanding of the brain mechanisms that underlie effective learning.
Neuroscientist Marlieke van Kesteren tested two groups of students who had just started on their second-year of biology or pedagogy studies. While an MRI scanner was registering their brain activity, the students learned short sentences containing new information that expanded on their own or the other study programme. The following day, the students were tested on the information they had learned. As expected, they had retained the information that was related to their own programme better than the unrelated information.
In practice
During the successful retention of related information, a different part of the brain was active than when unrelated information was memorised. ‘The brain area we found, the medial prefrontal cortex, probably linked new information directly to prior knowledge’, Van Kesteren said. ‘In previous studies this brain area came to the fore as well, but only during simple tests. We have specifically shown that this area also plays a role in the neural basis of learning in educational practice.’
Link to study results
To her amazement, Van Kesteren also discovered that the activity in the medial prefrontal cortex corresponded with how well students performed in their second year, compared with the first. So is it possible to predict a student’s future academic success by placing him or her in a scanner? ‘No, certainly not, the links we found were not strong enough’, Van Kesteren explained. ‘We’re mostly talking here about differences of not more than 10% (Figure 1). What’s more, we can’t tell from a simple correlation like this what the chief reason is, and whether a whole lot of other factors are playing a role. But if we know exactly how our brain uses prior knowledge, we could try to address that knowledge more selectively before we start learning new information. For example, you could consider how the new information is related to what you already know.’
Van Kesteren added a tip for secondary school students taking their final exams: ‘If you don’t immediately know the answer to a question, you could first try recalling what you already know about that topic. This might help you to come up with the right answer after all.’
This publication is part of Marlieke van Kesteren’s PhD research, for which she obtained her doctorate at Radboud University Nijmegen in March 2013. In April 2013 she received a Rubicon grant from the Netherlands Organisation for Scientific Research (NWO), allowing her to work on her research into prior knowledge and memory at Stanford University in California for the next two years.
Tracking the Source of “Selective Attention” Problems in Brain-Injured Vets
An estimated 15-20 percent of U.S. troops returning from Iraq and Afghanistan suffer from some form of traumatic brain injury (TBI) sustained during their deployment, with most injuries caused by blast waves from exploded military ordnance. The obvious cognitive symptoms of minor TBI — including learning and memory problems — can dissipate within just a few days. But blast-exposed veterans may continue to have problems performing simple auditory tasks that require them to focus attention on one sound source and ignore others, an ability known as “selective auditory attention.”
According to a new study by a team of Boston University (BU) neuroscientists, such apparent “hearing” problems actually may be caused by diffuse injury to the brain’s prefrontal lobe — work that will be described at the 167th meeting of the Acoustical Society of America, to be held May 5-9, 2014 in Providence, Rhode Island.
"This kind of injury can make it impossible to converse in everyday social settings, and thus is a truly devastating problem that can contribute to social isolation and depression," explains computational neuroscientist Scott Bressler, a graduate student in BU’s Auditory Neuroscience Laboratory, led by biomedical engineering professor Barbara Shinn-Cunningham.
For the study, Bressler, Shinn-Cunningham and their colleagues — in collaboration with traumatic brain injury and post-traumatic stress disorder expert Yelena Bogdanova of VA Healthcare Boston — presented a selective auditory attention task to 10 vets with mild TBI and to 17 control subjects without brain injuries. Notably, on average, veterans had hearing within a normal range.
In the task, three different melody streams, each comprised of two notes, were simultaneously presented to the subjects from three different perceived directions (this variation in directionality was achieved by differing the timing of the signals that reached the left and right ears). The subjects were then asked to identify the “shape” of the melodies (i.e., “going up,” “going down,” or “zig-zagging”) while their brain activity was measured by electrodes on the scalp.
"Whenever a new sound begins, the auditory cortex responds, encoding the sound onset," Bressler explains. "Attentional focus, however, changes the strength of this response: when a listener is attending to a particular sound source, the neural activity in response to that sound is greater." This change of the neural response occurs because the brain’s "executive control" regions, located in the brain’s prefrontal cortex, send signals to the auditory sensory regions of the brain, modulating their response.
The researchers found that blast-exposed veterans with TBI performed worse on the task — that is, they had difficulty controlling auditory attention — “and in all of the TBI veterans who performed well enough for us to measure their neural activity, 6 out of our 10 initial subjects, the brain response showed weak or no attention-related modulation of auditory responses,” Bressler says.
"Our hope is that some of our findings can be used to develop methods to assess and quantify TBI, identifying specific factors that contribute to difficulties communicating in everyday settings," he says. "By identifying these factors on an individual basis, we may be able to define rehabilitation approaches and coping strategies tailored to the individual."
Some TBI patients also go on to develop chronic traumatic encephalopathy (CTE) — a debilitating progressive degenerative disease with symptoms that include dementia, memory loss and depression — which can now only be definitively diagnosed after death. “With any luck,” Bressler adds, “neurobehavioral research like ours may help identify patients at risk of developing CTE long before their symptoms manifest.”
(Source: newswise.com)
The science behind rewards and punishment
In a neuroimaging study, a UQ psychologist has examined whether having allegiances with someone can affect feelings of empathy when punishing and rewarding others.
An international team of researchers, including Dr Pascal Molenberghs from UQ’s School of Psychology, mapped the brain activity while volunteers where giving electroshocks or money to members within or outside their group.
Dr Molenberghs said the research was a first of its kind and demonstrated that different neural responses were involved when delivering rewards or punishment to others.
“When we reward others we activate similar brain areas as when we receive rewards ourselves,” he said.
“However, these areas become more active when we reward members from our own group.
“Previous research has shown that we prefer to give more money to people from our own group, now we can actually show that this is associated with increased activation in reward-related brain areas, which is really exciting.
“The brain responses for punishing others directly revealed a different pattern of activation, one that was typically associated with receiving and seeing others in pain,” Dr Molenberghs said.
The study also found that personality traits influenced activity in these punishment-related brain areas.
People who did not care as much about others, showed less activation in these areas when shocking others, especially when they were shocking out-group members.
Co-author Professor Jean Decety, from the University of Chicago, said the results provided important insights into why some people don’t care as much when hurting others.
“Empathy and sympathy are necessary abilities to understand the potential consequences decisions will have on the feelings and emotions of others, even if the recipients of those decisions belong to a different group,” he said.
Musical training increases blood flow in the brain
Research by the University of Liverpool has found that brief musical training can increase the blood flow in the left hemisphere of our brain. This suggests that the areas responsible for music and language share common brain pathways.
Researchers from the University’s Institute of Psychology, Health and Society carried out two separate studies which looked at brain activity patterns in musicians and non-musicians.
The first study looking for patterns of brain activity of 14 musicians and 9 non-musicians whilst they participated in music and word generation tasks. The results showed that patterns in the musician’s brains were similar in both tasks but this was not the case for the non-musicians.
In the second study, brain activity patterns were measured in a different group of non-musical participants who took part in a word generation task and a music perception task.
The measurements were also taken again following half an hour’s musical training. The measurements of brain activity taken before the musical training* showed no significant pattern of correlation. However, following the training significant similarities were found.
Amy Spray, who conducted the research as part of a School of Psychology Summer Internship Scheme, said: “The areas of our brain that process music and language are thought to be shared and previous research has suggested that musical training can lead to the increased use of the left hemisphere of the brain.
This study looked into the modulatory effects that musical training could have on the use of the different sides of the brain when performing music and language tasks.”
Amy added: “It was fascinating to see that the similarities in blood flow signatures could be brought about after just half an hour of simple musical training.”
Liverpool Psychologist, Dr Georg Mayer, explained: “This suggests that the correlated brain patterns were the result of using areas thought to be involved in language processing. Therefore we can assume that musical training results in a rapid change in the cognitive mechansims utilised for music perception and these shared mechanisms are usually employed for language.”
Preparing for parenthood: Study finds pregnant women show increased activity in right side of brain
Pregnant women show increased activity in the area of the brain related to emotional skills as they prepare to bond with their babies, according to a new study by scientists at Royal Holloway, University of London.
The research, which will be presented at the British Psychological Society’s annual conference today (Wednesday 7 May), found that pregnant women use the right side of their brain more than new mothers do when they look at faces with emotive expressions.
“Our findings give us a significant insight into the ‘baby brain’ phenomenon that makes a woman more sensitive during the child bearing process”, said Dr Victoria Bourne, from the Department of Psychology at Royal Holloway. “The results suggest that during pregnancy, there are changes in how the brain processes facial emotions that ensure that mothers are neurologically prepared to bond with their babies at birth.”
Researcher examined the neuropsychological activity of 39 pregnant women and new mothers as they looked at images of adult and baby faces with either positive or negative expressions. The results showed that pregnant women used the right side of their brain more than new mothers, particularly when processing positive emotions.
The study used the chimeric faces test, which uses images made of one half of a neutral face combined with one half of an emotive face to see which side of the participants’ brain is used to process positive and negative emotions.
Dr Bourne said: “We know from previous research that pregnant women and new mothers are more sensitive to emotional expressions, particularly when looking at babies’ faces. We also know that new mothers who demonstrate symptoms of post-natal depression sometimes interpret their baby’s emotional expressions as more negative than they really are.
“Discovering the neuropsychological processes that may underpin these changes is a key step towards understanding how they might influence a mother’s bonding with her baby.”
(Source: alphagalileo.org)