Posts tagged anterograde amnesia

Posts tagged anterograde amnesia
I first met Henry Molaison more than half a century ago, during the spring of my third year in graduate school. I have tried to resurrect the details of my interactions with him that week, but human memory does not allow such excursions. The explicit minutiae of unique episodes fade as time passes, making it impossible for us to vividly re-experience the details of events in the distant past. What I do know is that I was very excited to have the opportunity to study such a rare case as Henry, and I had spent months preparing. Looking back at the results of all the tests he did that week, it was clear even then that the consequences of the operation carried out on him in 1957 – an experimental procedure to cure his epilepsy – had been catastrophic. Henry was left in a permanent state of amnesia, unable to retain any new information.
At the time of Henry’s operation, little was known about how memory processes worked. The extensive damage to the inner part of the temporal lobes on both sides of Henry’s brain made him a vital case study for memory researchers then and now. As the years passed, his fame grew and eventually spread to countries outside North America – and all that time Henry was stuck in the same moment. From time to time, I would tell him how important and well known he was, and he would smile sheepishly, as the praise was already slipping out of his consciousness. In his lifetime he was known as HM; only after his death, in 2008, was his identity revealed to the world.
The World’s Most Famous Brain
In the summer of 1953, Henry Gustav Molaison (1926-2008) underwent brain surgery to contain epileptic seizures that had become critically debilitating. The intervention brought some relief from convulsions, but these positive results were overshadowed by an astonishing and indelible side effect. Soon after the operation, it became apparent that he could no longer recognize hospital staff, he did not remember the way home, he did not remember newspaper articles he had just read, nor the crossword puzzles he had solved; otherwise, he was completely normal. Since the time of the surgery, more than five decades of scrupulous neuropsychological research examined the nature of patient H.M.’s amnesia which proved to be both persistent and remarkably selective.
The goal of our project is to provide a window into the brain of the man who helped establish the scientific study of memory and unfailingly forgot the enormously generous contribution he made to medical research.