Neuroscience

Articles and news from the latest research reports.

91 notes

Commands from the matrix: Cellular environment controls formation and activity of neuronal connections
Environment moulds behaviour - and not just that of people in society, but also at the microscopic level. This is because, for their function, neurons are dependent on the cell environment, the so-termed extracellular matrix. Researchers at the Ruhr-Universität have found evidence that this complex network of molecules controls the formation and activity of the neuronal connections. The team led by Dr. Maren Geißler und Prof. Andreas Faissner from the Department of Cell Morphology and Molecular Neurobiology reports in the “Journal of Neuroscience” in collaboration with the team of Dr. Ainhara Aguado, Prof. Christian Wetzel and Prof. Hanns Hatt from the Department of Cell Physiology.
Neurons and astrocytes in culture
In cooperation with Prof. Uwe Rauch from Lund University in Sweden, Bochum’s biologists examined cells from the brains of two mouse species: a species with a normal extracellular matrix and a species which lacked four components of the extracellular matrix due to genetic manipulation, namely the molecules tenascin-C, tenascin-R, neurocan and brevican. They took the cells from the hippocampus, a brain structure that is crucial for the long-term memory. The team not only examined neurons but also astrocytes, which are in close contact with the neurons, support their function and secrete molecules for the extracellular matrix.
Formation, stability and activity of the neuronal connections depend on the matrix
The researchers cultivated the neurons and astrocytes together for four weeks with a specially developed culture strategy. Among other things, they observed how many connections, known as synapses, the neurons formed with each other and how stable these were over time. If either the astrocytes or the neurons in the culture dish derived from animals with a reduced extracellular matrix, these synapses proved to be less stable in the medium term, and their number was significantly reduced. Together with the Department of Cell Physiology at the RUB and the University of Regensburg, the team also showed that the neurons with a mutated matrix showed lower spontaneous activity than normal cells. The extracellular matrix thus regulates the formation, stability and activity of the neuronal connections. The researchers also examined a special structure of the extracellular matrix, the so-called perineuronal nets, which the Nobel laureate Camillo Golgi first described more than a century ago. They were significantly reduced in the environment of genetically modified cells.

Commands from the matrix: Cellular environment controls formation and activity of neuronal connections

Environment moulds behaviour - and not just that of people in society, but also at the microscopic level. This is because, for their function, neurons are dependent on the cell environment, the so-termed extracellular matrix. Researchers at the Ruhr-Universität have found evidence that this complex network of molecules controls the formation and activity of the neuronal connections. The team led by Dr. Maren Geißler und Prof. Andreas Faissner from the Department of Cell Morphology and Molecular Neurobiology reports in the “Journal of Neuroscience” in collaboration with the team of Dr. Ainhara Aguado, Prof. Christian Wetzel and Prof. Hanns Hatt from the Department of Cell Physiology.

Neurons and astrocytes in culture

In cooperation with Prof. Uwe Rauch from Lund University in Sweden, Bochum’s biologists examined cells from the brains of two mouse species: a species with a normal extracellular matrix and a species which lacked four components of the extracellular matrix due to genetic manipulation, namely the molecules tenascin-C, tenascin-R, neurocan and brevican. They took the cells from the hippocampus, a brain structure that is crucial for the long-term memory. The team not only examined neurons but also astrocytes, which are in close contact with the neurons, support their function and secrete molecules for the extracellular matrix.

Formation, stability and activity of the neuronal connections depend on the matrix

The researchers cultivated the neurons and astrocytes together for four weeks with a specially developed culture strategy. Among other things, they observed how many connections, known as synapses, the neurons formed with each other and how stable these were over time. If either the astrocytes or the neurons in the culture dish derived from animals with a reduced extracellular matrix, these synapses proved to be less stable in the medium term, and their number was significantly reduced. Together with the Department of Cell Physiology at the RUB and the University of Regensburg, the team also showed that the neurons with a mutated matrix showed lower spontaneous activity than normal cells. The extracellular matrix thus regulates the formation, stability and activity of the neuronal connections. The researchers also examined a special structure of the extracellular matrix, the so-called perineuronal nets, which the Nobel laureate Camillo Golgi first described more than a century ago. They were significantly reduced in the environment of genetically modified cells.

Filed under astrocytes neurons hippocampus extracellular matrix neuronal connections neuroscience science

  1. eyewire reblogged this from neurosciencestuff
  2. dis-astri reblogged this from neurosciencestuff
  3. void1984 reblogged this from polymath4ever
  4. polymath4ever reblogged this from neurosciencestuff
  5. elfmachinez reblogged this from neurosciencestuff
  6. brainsx reblogged this from molecularlifesciences
  7. alter-eggo reblogged this from molecularlifesciences
  8. c0git0 reblogged this from molecularlifesciences
  9. the-electric-boogaloo reblogged this from molecularlifesciences
  10. onequantaaway reblogged this from molecularlifesciences and added:
    The tripartite synapse
  11. dermoosealini reblogged this from molecularlifesciences
  12. molecularlifesciences reblogged this from diamidinophenylindolee
  13. okorogariist reblogged this from neurosciencestuff
  14. ianoli reblogged this from neurosciencestuff
  15. spacepetals reblogged this from neurosciencestuff
  16. shellwhetu reblogged this from neurosciencestuff
  17. mrzimdlr reblogged this from neurosciencestuff and added:
  18. wladyhen reblogged this from neurosciencestuff and added:
    oooh me gusta *-*
  19. natalialt125 reblogged this from neurosciencestuff
  20. diamidinophenylindolee reblogged this from neurosciencestuff
  21. jackoshadows reblogged this from neurosciencestuff
  22. mc-reg reblogged this from neurosciencestuff
free counters