Repeated aggressions trigger social aversion in mice

One of the mechanisms involved in the onset of stress-induced depression has been highlighted in mice by researchers from CNRS, Inserm and UPMC. They have determined the role of the corticosterone (stress hormone) receptor, in the long-term behavioral change triggered by chronic stress. In mice subject to repeated aggressions, this receptor participates in the development of social aversion by controlling the release of dopamine, a key chemical messenger. If this receptor is blocked, the animals become “resilient”: although anxious, they overcome the trauma and no longer avoid contact with their fellow creatures. This work is published in Science on 18 January 2013.