Neuroscience

Articles and news from the latest research reports.

54 notes

Induction of adult cortical neurogenesis by an antidepressant

The production of new neurons in the adult normal cortex in response to the antidepressant, fluoxetine, is reported in a study published online this week in Neuropsychopharmacology.

The research team, which is based at the Institute for Comprehensive Medical Science, Fujita Health University, Aichi, has previously demonstrated that neural progenitor cells exist at the surface of the adult cortex, and, moreover, that ischemia enhances the generation of new inhibitory neurons from these neural progenitor cells. These cells were accordingly named “Layer 1 Inhibitory Neuron Progenitor cells” (L1-INP). However, until now it was not known whether L1-INP-related neurogenesis could be induced in the normal adult cortex.

Tsuyoshi Miyakawa, Koji Ohira, and their colleagues employed fluoxetine, a selective serotonin reuptake inhibitor, and one of the most widely used antidepressants, to stimulate the production of new neurons from L1-INP cells. A large percentage of these newly generated neurons were inhibitory GABAergic interneurons, and their generation coincided with a reduction in apoptotic cell death following ischemia. This finding highlights the potential neuroprotective response induced by this antidepressant drug. It also lends further support to the postulation that induction of adult neurogenesis in cortex is a relevant prevention/treatment option for neurodegenerative diseases and psychiatric disorders.

(Source: eurekalert.org)

Filed under neurogenesis fluoxetine neuron antidepressants interneurons neuroscience science

  1. its-mc-bitch reblogged this from neurosciencestuff
  2. h3althynormal reblogged this from neurosciencestuff
  3. hiddenprince44 reblogged this from neurosciencestuff
  4. brainstufffyi4dew0319 reblogged this from neurosciencestuff
  5. emilypeapot reblogged this from neurosciencestuff and added:
    :/
  6. sedatbatmaz reblogged this from neurosciencestuff
  7. roads2roam reblogged this from neurosciencestuff
  8. brilliantstreet reblogged this from neurosciencestuff
  9. graceevolved reblogged this from neurosciencestuff
  10. catspiritanimal reblogged this from neurosciencestuff
  11. reikarabbit reblogged this from neurosciencestuff
  12. hioe reblogged this from neurosciencestuff
  13. urpiloma reblogged this from neurosciencestuff
  14. godammitkitty reblogged this from neurosciencestuff and added:
    Fluoxetine (SSRI), specifically
  15. ashtar-sheran reblogged this from neurosciencestuff
  16. overloadedwithwanderlust reblogged this from neurosciencestuff
  17. curiositycreature reblogged this from neurosciencestuff
  18. opus-pocus reblogged this from neurosciencestuff and added:
    This is undoubtedly good news, but I always-always have my misgivings about the implementation of medicines. especially...
  19. dwarf-with-a-jetpack reblogged this from squishysound
free counters