Neuroscience

Articles and news from the latest research reports.

52 notes

Hippocampal Pyramidal Neurons Comprise Two Distinct Cell Types that Are Countermodulated by Metabotropic Receptors
Relating the function of neuronal cell types to information processing and behavior is a central goal of neuroscience. In the hippocampus, pyramidal cells in CA1 and the subiculum process sensory and motor cues to form a cognitive map encoding spatial, contextual, and emotional information, which they transmit throughout the brain. Do these cells constitute a single class or are there multiple cell types with specialized functions? Using unbiased cluster analysis, we show that there are two morphologically and electrophysiologically distinct principal cell types that carry hippocampal output. We show further that these two cell types are inversely modulated by the synergistic action of glutamate and acetylcholine acting on metabotropic receptors that are central to hippocampal function. Combined with prior connectivity studies, our results support a model of hippocampal processing in which the two pyramidal cell types are predominantly segregated into two parallel pathways that process distinct modalities of information.

Hippocampal Pyramidal Neurons Comprise Two Distinct Cell Types that Are Countermodulated by Metabotropic Receptors

Relating the function of neuronal cell types to information processing and behavior is a central goal of neuroscience. In the hippocampus, pyramidal cells in CA1 and the subiculum process sensory and motor cues to form a cognitive map encoding spatial, contextual, and emotional information, which they transmit throughout the brain. Do these cells constitute a single class or are there multiple cell types with specialized functions? Using unbiased cluster analysis, we show that there are two morphologically and electrophysiologically distinct principal cell types that carry hippocampal output. We show further that these two cell types are inversely modulated by the synergistic action of glutamate and acetylcholine acting on metabotropic receptors that are central to hippocampal function. Combined with prior connectivity studies, our results support a model of hippocampal processing in which the two pyramidal cell types are predominantly segregated into two parallel pathways that process distinct modalities of information.

Filed under pyramidal cells hippocampal neurons brain metabotropic receptors neuroscience science

  1. ohgodwhoseroomsarethese reblogged this from anemonepiperi
  2. anemonepiperi reblogged this from neurosciencestuff
  3. inklinedflowers reblogged this from neurosciencestuff
  4. ambiguous-genitalia reblogged this from neurosciencestuff
  5. dominiq379 reblogged this from neurosciencestuff
  6. jadeisgazingtbyss reblogged this from neurosciencestuff
  7. lawallahi reblogged this from neurosciencestuff
  8. nightfox202000 reblogged this from neurosciencestuff
  9. brainstufffyi4dew0319 reblogged this from neurosciencestuff
  10. dancub reblogged this from neurosciencestuff
  11. machetedroid reblogged this from neurosciencestuff
  12. rehearsing---interaction reblogged this from neurosciencestuff
  13. sirlowkey reblogged this from neurosciencestuff
  14. criesaboutfalloutboy reblogged this from neurosciencestuff
  15. mammals-in-motion reblogged this from neurosciencestuff
  16. neurosciencestuff posted this
free counters