Neuroscience

Articles and news from the latest research reports.

95 notes


Breakthrough nanoparticle halts multiple sclerosis
In a breakthrough for nanotechnology and multiple sclerosis, a biodegradable nanoparticle turns out to be the perfect vehicle to stealthily deliver an antigen that tricks the immune system into stopping its attack on myelin and halt a model of relapsing remitting multiple sclerosis (MS) in mice, according to new Northwestern Medicine research.
The new nanotechnology also can be applied to a variety of immune-mediated diseases including Type 1 diabetes, food allergies and airway allergies such as asthma.
In MS, the immune system attacks the myelin membrane that insulates nerves cells in the brain, spinal cord and optic nerve. When the insulation is destroyed, electrical signals can’t be effectively conducted, resulting in symptoms that range from mild limb numbness to paralysis or blindness. About 80 percent of MS patients are diagnosed with the relapsing remitting form of the disease.
The Northwestern nanotechnology does not suppress the entire immune system as do current therapies for MS, which make patients more susceptible to everyday infections and higher rates of cancer. Rather, when the nanoparticles are attached to myelin antigens and injected into the mice, the immune system is reset to normal. The immune system stops recognizing myelin as an alien invader and halts its attack on it.
"This is a highly significant breakthrough in translational immunotherapy," said Stephen Miller, a corresponding author of the study and the Judy Gugenheim Research Professor of Microbiology-Immunology at Northwestern University Feinberg School of Medicine. "The beauty of this new technology is it can be used in many immune-related diseases. We simply change the antigen that’s delivered."
"The holy grail is to develop a therapy that is specific to the pathological immune response, in this case the body attacking myelin," Miller added. "Our approach resets the immune system so it no longer attacks myelin but leaves the function of the normal immune system intact."
The nanoparticle, made from an easily produced and already FDA-approved substance, was developed by Lonnie Shea, professor of chemical and biological engineering at Northwestern’s McCormick School of Engineering and Applied Science.
"This is a major breakthrough in nanotechnology, showing you can use it to regulate the immune system," said Shea, also a corresponding author. The paper was published Nov. 18 in the journal Nature Biotechnology.

Breakthrough nanoparticle halts multiple sclerosis

In a breakthrough for nanotechnology and multiple sclerosis, a biodegradable nanoparticle turns out to be the perfect vehicle to stealthily deliver an antigen that tricks the immune system into stopping its attack on myelin and halt a model of relapsing remitting multiple sclerosis (MS) in mice, according to new Northwestern Medicine research.

The new nanotechnology also can be applied to a variety of immune-mediated diseases including Type 1 diabetes, food allergies and airway allergies such as asthma.

In MS, the immune system attacks the myelin membrane that insulates nerves cells in the brain, spinal cord and optic nerve. When the insulation is destroyed, electrical signals can’t be effectively conducted, resulting in symptoms that range from mild limb numbness to paralysis or blindness. About 80 percent of MS patients are diagnosed with the relapsing remitting form of the disease.

The Northwestern nanotechnology does not suppress the entire immune system as do current therapies for MS, which make patients more susceptible to everyday infections and higher rates of cancer. Rather, when the nanoparticles are attached to myelin antigens and injected into the mice, the immune system is reset to normal. The immune system stops recognizing myelin as an alien invader and halts its attack on it.

"This is a highly significant breakthrough in translational immunotherapy," said Stephen Miller, a corresponding author of the study and the Judy Gugenheim Research Professor of Microbiology-Immunology at Northwestern University Feinberg School of Medicine. "The beauty of this new technology is it can be used in many immune-related diseases. We simply change the antigen that’s delivered."

"The holy grail is to develop a therapy that is specific to the pathological immune response, in this case the body attacking myelin," Miller added. "Our approach resets the immune system so it no longer attacks myelin but leaves the function of the normal immune system intact."

The nanoparticle, made from an easily produced and already FDA-approved substance, was developed by Lonnie Shea, professor of chemical and biological engineering at Northwestern’s McCormick School of Engineering and Applied Science.

"This is a major breakthrough in nanotechnology, showing you can use it to regulate the immune system," said Shea, also a corresponding author. The paper was published Nov. 18 in the journal Nature Biotechnology.

Filed under nanoparticles MS immune system nanotechnology diabetes myelin medicine neuroscience science

  1. kaitheyun reblogged this from neurosciencestuff
  2. h3althynormal reblogged this from neurosciencestuff
  3. sliverdemon reblogged this from neurosciencestuff
  4. a-madsci reblogged this from neurosciencestuff
  5. graphitenpixels reblogged this from neurosciencestuff
  6. ayraethazide reblogged this from neurosciencestuff
  7. true-antagonist reblogged this from neurosciencestuff
  8. moderatelycomposed reblogged this from banner-and-the-other-guy
  9. geschwindigkeitshubbel reblogged this from awkwardlypainful
  10. robintheghost reblogged this from neurosciencestuff
  11. silver-antlers reblogged this from banner-and-the-other-guy
  12. maxxxie74 reblogged this from neurosciencestuff
  13. pharmuscidea reblogged this from neurosciencestuff
  14. thespookyscienceofficer reblogged this from an-airship-full-of-spiders
  15. void1984 reblogged this from neurosciencestuff
  16. godammitkitty reblogged this from neurosciencestuff and added:
    I’d be careful w/ “Breakthrough” language & #MS but this is indeed very cool: “when the nanoparticles are attached to...
  17. kakini3 reblogged this from neurosciencestuff and added:
    I am SOOOOOOO excited by these types of breakthroughs!!!
  18. shadowingeffect reblogged this from neurosciencestuff
  19. justinjazzitup reblogged this from neurosciencestuff
  20. privatepersonalblog reblogged this from neurosciencestuff
  21. destinedreign reblogged this from neurosciencestuff
  22. awkwardlypainful reblogged this from neurosciencestuff and added:
    GUYS, THIS IS BIG NEWS.
  23. sweetxdreams1536 reblogged this from neurosciencestuff
free counters