Study explores how brain disruption may foster schizophrenia

Yale University researchers have discovered an innovative way to study how large brain systems are organized, an advance that has already provided insights into diseases such as schizophrenia.

The Yale team used a combination of neuroimaging, computational neurobiology, and pharmacological techniques to reveal functioning at both the cellular level and across larger brain regions.

In a paper in Proceedings of the National Academy of Sciences the week of Sept. 24, Yale scientists use this approach to show that a disruption of a particular signaling mechanisms within larger neural systems may be contribute to schizophrenia symptoms.