Neuroscience

Articles and news from the latest research reports.

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Irony seen through the eye of MRI
A French team has shown that the activation of the ToM neural network increases when an individual is reacting to ironic statements. Published in Neuroimage, these findings represent an important breakthrough in the study of Theory of Mind and linguistics, shedding light on the mechanisms involved in interpersonal communication. 
In our communications with others, we are constantly thinking beyond the basic meaning of words. For example, if asked, “Do you have the time?” one would not simply reply, “Yes.” The gap between what is said and what it means is the focus of a branch of linguistics called pragmatics. In this science, “Theory of Mind” (ToM) gives listeners the capacity to fill this gap. In order to decipher the meaning and intentions hidden behind what is said, even in the most casual conversation, ToM relies on a variety of verbal and non-verbal elements: the words used, their context, intonation, “body language,” etc.

Irony seen through the eye of MRI

A French team has shown that the activation of the ToM neural network increases when an individual is reacting to ironic statements. Published in Neuroimage, these findings represent an important breakthrough in the study of Theory of Mind and linguistics, shedding light on the mechanisms involved in interpersonal communication.

In our communications with others, we are constantly thinking beyond the basic meaning of words. For example, if asked, “Do you have the time?” one would not simply reply, “Yes.” The gap between what is said and what it means is the focus of a branch of linguistics called pragmatics. In this science, “Theory of Mind” (ToM) gives listeners the capacity to fill this gap. In order to decipher the meaning and intentions hidden behind what is said, even in the most casual conversation, ToM relies on a variety of verbal and non-verbal elements: the words used, their context, intonation, “body language,” etc.

Filed under science neuroscience brain psychology theory of mind language linguistics pragmatics MRI neuroimaging communication

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How Low Can You Go? Physical Production Mechanism of Elephant Infrasonic Vocalizations
Elephants can communicate using sounds below the range of human hearing (“infrasounds” below 20 hertz). It is commonly speculated that these vocalizations are produced in the larynx, either by neurally controlled muscle twitching (as in cat purring) or by flow-induced self-sustained vibrations of the vocal folds (as in human speech and song). We used direct high-speed video observations of an excised elephant larynx to demonstrate flow-induced self-sustained vocal fold vibration in the absence of any neural signals, thus excluding the need for any “purring” mechanism. The observed physical principles of voice production apply to a wide variety of mammals, extending across a remarkably large range of fundamental frequencies and body sizes, spanning more than five orders of magnitude.

Read more here

How Low Can You Go? Physical Production Mechanism of Elephant Infrasonic Vocalizations

Elephants can communicate using sounds below the range of human hearing (“infrasounds” below 20 hertz). It is commonly speculated that these vocalizations are produced in the larynx, either by neurally controlled muscle twitching (as in cat purring) or by flow-induced self-sustained vibrations of the vocal folds (as in human speech and song). We used direct high-speed video observations of an excised elephant larynx to demonstrate flow-induced self-sustained vocal fold vibration in the absence of any neural signals, thus excluding the need for any “purring” mechanism. The observed physical principles of voice production apply to a wide variety of mammals, extending across a remarkably large range of fundamental frequencies and body sizes, spanning more than five orders of magnitude.

Read more here

Filed under science neuroscience animals mammals vocalizations larynx infrasounds vocals voice production

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Musicians’ Brains Might Have an Edge on Aging
It’s been said that music soothes the savage beast, but if you’re the one playing the instrument it might benefit your brain.
A growing body of evidence suggests that learning to play an instrument and continuing to practice and play it may offer mental benefits throughout life. Hearing has also been shown to be positively affected by making music.

Musicians’ Brains Might Have an Edge on Aging

It’s been said that music soothes the savage beast, but if you’re the one playing the instrument it might benefit your brain.

A growing body of evidence suggests that learning to play an instrument and continuing to practice and play it may offer mental benefits throughout life. Hearing has also been shown to be positively affected by making music.

Filed under brain cognition memory music neuroscience psychology science ageing

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Intelligence: Brain size matters, but so do connections
Measuring human intelligence may be controversial and oh-so-very-tricky to do. The latest study underscores a growing appreciation among neuroscientists for the importance of the brain’s “white matter” — fat-covered clusters of axons that string neurons and the brain’s two hemispheres together— in brain function.

Intelligence: Brain size matters, but so do connections

Measuring human intelligence may be controversial and oh-so-very-tricky to do. The latest study underscores a growing appreciation among neuroscientists for the importance of the brain’s “white matter” — fat-covered clusters of axons that string neurons and the brain’s two hemispheres together— in brain function.

Filed under brain goal-directed behavior intelligence lateral prefrontal cortex neuroscience psychology science white matter performance

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Cancer May Result From Wrong Number of Genes
When a young person develops cancer, doctors most often assume that genetics are the reason, because the patient hasn’t lived long enough to accumulate environmental damage. But it’s been hard to find the faulty DNA behind many tumors. Now, using new genomic technology, scientists have discovered a novel explanation for some testicular cancers, the most common cause of cancer in men under 35. Rather than being triggered by a single gene mutation, the tumors are caused by too many or too few copies of a gene in a person’s cells. These “copy number variations” have been linked to other conditions such as autism, but never before to cancer.

Cancer May Result From Wrong Number of Genes

When a young person develops cancer, doctors most often assume that genetics are the reason, because the patient hasn’t lived long enough to accumulate environmental damage. But it’s been hard to find the faulty DNA behind many tumors. Now, using new genomic technology, scientists have discovered a novel explanation for some testicular cancers, the most common cause of cancer in men under 35. Rather than being triggered by a single gene mutation, the tumors are caused by too many or too few copies of a gene in a person’s cells. These “copy number variations” have been linked to other conditions such as autism, but never before to cancer.

Filed under brain cancer genes genomics neuroscience psychology science testicular cancer genetics

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The psychological techniques we use to avoid each other on the bus
A sociologist who rode coach buses for three years has codified the unspoken rules of avoiding total strangers.
"We live in a world of strangers, where life in public spaces feels increasingly anonymous," said sociologist Esther Kim of Yale University in a press release. “However, avoiding other people actually requires quite a lot of effort and this is especially true in confined spaces like public transport.”

The psychological techniques we use to avoid each other on the bus

A sociologist who rode coach buses for three years has codified the unspoken rules of avoiding total strangers.

"We live in a world of strangers, where life in public spaces feels increasingly anonymous," said sociologist Esther Kim of Yale University in a press release. “However, avoiding other people actually requires quite a lot of effort and this is especially true in confined spaces like public transport.”

Filed under eye contact neuroscience personal space psychology public distance science social social distance sociology stranger

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Disorders of consciousness: How should clinicians respond to new therapeutic interventions?

August 2, 2012

New tools have confirmed high rates of misdiagnosis of patients with chronic disorders of consciousness, such as the vegetative state. An increasing number of patients’ families wish to use these novel techniques for diagnosis, prognosis, and treatment. An international team of researchers, including Dr. Éric Racine, researcher at the IRCM, analyzed the clinical, social and ethical issues that clinicians are now facing. Their article is published in the August edition of The Lancet Neurology, a renowned journal in the field of clinical neurology.

"Patients with disorders of consciousness have traditionally been regarded as unaware by definition, but findings from recent clinical studies have revealed astounding cases of awareness despite clinical unresponsiveness," explains Dr. Racine, a Montréal neuroethics specialist.

Severe brain injury can leave patients with chronic disorders of consciousness, which are medical conditions that inhibit consciousness. Patients thus have severe motor and cognitive impairments, remain fully dependent on others for all activities of daily living, and have no or very limited means to functionally communicate their thoughts or wishes, depending on their state.

Even with a careful neurological assessment of these types of disorders, some signs of awareness can elude the clinician because the clinical diagnosis relies on the observation of motor signs of awareness, which can be very subtle and fluctuate over time.

New technological developments can now measure brain function both in resting states and in response to simple commands, independent of muscle function, which could help establish a more accurate diagnosis. As a result, diagnostic classifications have been revised and prognostic knowledge is improving. For the first time, therapeutic studies have recently shown the effects of treatment on the improvement of patient responsiveness.

"The medical decision to stop or continue rehabilitation, or to transfer a patient to a long-term care facility can be hard to accept for the family, but one of the most difficult treatment decisions by family members remains whether to continue life-sustaining therapy or to discontinue it and only provide palliative care," says Dr. Racine.

Media coverage of disorders of consciousness has increased and information on the subject is increasingly available to the public. Clinicians such as neurologists, rehabilitation specialists, family doctors, and nurses must answer more requests from patients’ family members for novel diagnostic and therapeutic procedures.

"Clinicians therefore need to be prepared to discuss disorders of consciousness with ethical sensitivity, especially considering that the new procedures remain investigational," adds Dr. Racine. "They must be aware of the level of evidence supporting them and of the unavoidable ethical and social issues involved in responding to requests from patients’ family members."

Provided by Institut de recherches cliniques de Montreal

Source: medicalxpress.com

Filed under brain cognition consciousness disorders neuroscience research science therapy intervention

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Fixing the way we fix the brain
Of all the health challenges humans face, few are as insidious as those that involve the death or dysfunction of cells in our brains. These illnesses, a category known as neurodegenerative disease, take from us the very things that make us who we are — our thoughts and our memories, our ability to recognize loved ones, control of our bodies, even our cognitive identity.
For most, diseases such as Alzheimer’s or Parkinson’s attack slowly, leading us down a slope of gradually deteriorating mental or physical function that current scientific methods are able to diagnose only after debilitating symptoms have set in. Even if discovered early, there is no way to prevent their onset, no way to reverse the damage, and no cures.
Driven by the desperate need for better understanding and treatments, a coalition of academic researchers, pharmaceutical companies, and state government is now coming together to confront this challenge in a novel way.

Fixing the way we fix the brain

Of all the health challenges humans face, few are as insidious as those that involve the death or dysfunction of cells in our brains. These illnesses, a category known as neurodegenerative disease, take from us the very things that make us who we are — our thoughts and our memories, our ability to recognize loved ones, control of our bodies, even our cognitive identity.

For most, diseases such as Alzheimer’s or Parkinson’s attack slowly, leading us down a slope of gradually deteriorating mental or physical function that current scientific methods are able to diagnose only after debilitating symptoms have set in. Even if discovered early, there is no way to prevent their onset, no way to reverse the damage, and no cures.

Driven by the desperate need for better understanding and treatments, a coalition of academic researchers, pharmaceutical companies, and state government is now coming together to confront this challenge in a novel way.

Filed under science neuroscience brain psychology treatment scientific methods academics neurodegenerative diseases

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