Diseases that progressively destroy nerve cells in the brain or spinal cord, such as Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), are devastating conditions with no cures.
Now, a team that includes a University of Iowa researcher has identified a new class of small molecules, called the P7C3 series, which block cell death in animal models of these forms of neurodegenerative disease. The P7C3 series could be a starting point for developing drugs that might help treat patients with these diseases. These findings are reported in two new studies published the week of Oct. 1 in the online early edition of the Proceedings of the National Academy of Sciences (PNAS).
“We believe that our strategy for identifying and testing these molecules in animal models of disease gives us a rational way to develop a new class of neuroprotective drugs, for which there is a great, unmet need,” says Andrew Pieper, M.D., Ph.D., associate professor of psychiatry at the UI Carver College of Medicine, and senior author of the two studies.
About six years ago, Pieper, then at the University of Texas Southwestern Medical Center, and his colleagues screened thousands of compounds in living mice in search of small, drug-like molecules that could boost production of neurons in a region of the brain called the hippocampus. They found one compound that appeared to be particularly successful and called it P7C3.
“We were interested in the hippocampus because new neurons are born there every day. But, this neurogenesis is dampened by certain diseases and also by normal aging,” Pieper explains. “We were looking for small drug-like molecules that might enhance production of new neurons and help maintain proper functioning in the hippocampus.”
However, when the researchers looked more closely at P7C3, they found that it worked by protecting the newborn neurons from cell death. That finding prompted them to ask whether P7C3 might also protect existing, mature neurons in other regions of the nervous system from dying as well, as occurs in neurodegenerative disease.
Using mouse and worm models of PD and a mouse model of ALS, the research team has now shown that P7C3 and a related, more active compound, P7C3A20, do in fact potently protect the neurons that normally are destroyed by these diseases. Their studies also showed that protection of the neurons correlates with improvement of some disease symptoms, including maintaining normal movement in PD worms, and coordination and strength in ALS mice.
(Source: now.uiowa.edu)
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Filed under brain neurodegenerative diseases P7C3 cell death neuroscience psychology science
A new font tailored for people afflicted with dyslexia is now available for use on mobile devices, thanks to a design by Abelardo Gonzalez, a mobile app designer from New Hampshire. Gonzalez, in collaboration with educators, has selected a font that many people with dyslexia find easier to read. Even better, the new font is free and has already been made available for some word processors and ebook readers. The font, called OpenDyslexic, has also been added to the font choices used by Instapaper—a program that allows users to copy a web page and save it to their hard drive.
Filed under brain language dyslexia neuroscience psychology education science
Cognitive signals for brain–machine interfaces in posterior parietal cortex include continuous 3D trajectory commands
Cortical neural prosthetics extract command signals from the brain with the goal to restore function in paralyzed or amputated patients. Continuous control signals can be extracted from the motor cortical areas, whereas neural activity from posterior parietal cortex (PPC) can be used to decode cognitive variables related to the goals of movement. Because typical activities of daily living comprise both continuous control tasks such as reaching, and tasks benefiting from discrete control such as typing on a keyboard, availability of both signals simultaneously would promise significant increases in performance and versatility. Here, we show that PPC can provide 3D hand trajectory information under natural conditions that would be encountered for prosthetic applications, thus allowing simultaneous extraction of continuous and discrete signals without requiring multisite surgical implants. We found that limb movements can be decoded robustly and with high accuracy from a small population of neural units under free gaze in a complex 3D point-to-point reaching task. Both animals’ brain-control performance improved rapidly with practice, resulting in faster target acquisition and increasing accuracy. These findings disprove the notion that the motor cortical areas are the only candidate areas for continuous prosthetic command signals and, rather, suggests that PPC can provide equally useful trajectory signals in addition to discrete, cognitive variables. Hybrid use of continuous and discrete signals from PPC may enable a new generation of neural prostheses providing superior performance and additional flexibility in addressing individual patient needs.
Filed under brain neural prosthetics neuroscience posterior parietal cortex psychology motor cortex science
Auto experts recognize cars like most people recognize faces
When people – and monkeys – look at faces, a special part of their brain that is about the size of a blueberry “lights up.” Now, the most detailed brain-mapping study of the area yet conducted has confirmed that it isn’t limited to processing faces, as some experts have maintained, but instead serves as a general center of expertise for visual recognition.
Neuroscientists previously established that this region, which is called the fusiform face area (FFA) and is located in the temporal lobe, is responsible for a particularly effective form of visual recognition. But there has been an ongoing debate about whether this area is hard-wired to recognize faces because of their importance to us or if it is a more general mechanism that allows us to rapidly recognize objects that we work with extensively.
In the new study published this week in the online early edition of the Proceedings of the National Academy of Sciences, a team of Vanderbilt researchers report that they have recorded the activity in the FFAs of a group of automobile aficionados at extremely high resolution using one the most powerful MRI scanners available for human use and found no evidence that there is a special area devoted exclusively to facial recognition. Instead, they found that the FFA of the auto experts was filled with small, interspersed patches that respond strongly to photos of faces and autos both.
Filed under brain face recognition FFA neuroimaging neuroscience psychology science
The New Medicine: Hacking Our Biology is part of the series “Engineers of the New Millennium” from IEEE Spectrum magazine and the Directorate for Engineering of the National Science Foundation. These stories explore technological advances in medical inventions to enhance and extend life.
Filed under technology science brain robotics neuroscience
Scientists at the Universities of Sheffield and Sussex are embarking on an ambitious project to produce the first accurate computer models of a honey bee brain in a bid to advance our understanding of Artificial Intelligence (AI), and how animals think.
The team will build models of the systems in the brain that govern a honey bee’s vision and sense of smell. Using this information, the researchers aim to create the first flying robot able to sense and act as autonomously as a bee, rather than just carry out a pre-programmed set of instructions.
If successful, this project will meet one of the major challenges of modern science: building a robot brain that can perform complex tasks as well as the brain of an animal. Tasks the robot will be expected to perform, for example, will include finding the source of particular odours or gases in the same way that a bee can identify particular flowers.
It is anticipated that the artificial brain could eventually be used in applications such as search and rescue missions, or even mechanical pollination of crops.
Filed under brain green brain bee AI robots neuroscience science
Neuroscientists today can preserve small volumes (<1mm³) of animal brain tissue immediately after death with incredible precision — the features and structure of every synapse within these volumes is well-protected down to the nanometer scale, using an inexpensive, room-temperature process of chemical fixation and plastic embedding, or “plastination.” This image is an example of plastination and local circuit tracing, occurring in leading neuroscience labs around the world today. (Credit: Brain Preservation Foundation)
Chemical brain preservation: how to live ‘forever’ — a personal view
Filed under brain brain preservation chemical preservation neuroscience psychology science
What the brain draws from: Art and neuroscience
The human brain is wired in such a way that we can make sense of lines, colors and patterns on a flat canvas. Artists throughout human history have figured out ways to create illusions such as depth and brightness that aren’t actually there but make works of art seem somehow more real.
And while individual tastes are varied and have cultural influences, the brain also seems to respond especially strongly to certain artistic conventions that mimic what we see in nature.
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Filed under brain cognition art neuroesthetics neuroscience psychology science
15 Studied Effects of Classical Music on Your Brain
Classical music, whether you love it or hate it, has been a powerful cultural force for centuries. While it no longer dominates the music scene, the argument for continued appreciation of the genre goes far beyond pure aural aesthetics. Classical music has been lauded for its ability to do everything from improve intelligence to reduce stress, and despite some exaggeration of its benefits, science shows us that it actually does have a marked effect on the brain in a number of positive ways.
With September being Classical Music Month, there’s no better time to learn a bit more about some of the many ways classical music affects the brain. Over the past few decades, there have been numerous studies on the brain’s reaction to classical music, and we’ve shared the most relevant, interesting, and surprising here, some of which may motivate you to become a classical aficionado yourself.
Filed under brain music classical music neuroscience psychology science
