Angry? Sad? Ashamed? Depressed people can’t tell difference
Clinically depressed people have a hard time telling the difference between negative emotions such as anger and guilt, a new University of Michigan study found.
The ability to distinguish between various emotional experiences affects how individuals deal with life stressors, said Emre Demiralp, a researcher in the U-M Department of Psychology and the lead author of the study recently published in Psychological Science.
Being unable to differentiate certain emotions from each other might lead to a person choosing an action that is not appropriate, thus exacerbating the problem, she said.
"It is difficult to improve your life without knowing whether you are sad or angry about some aspect of it," Demiralp said. "For example, imagine not having a gauge independently indicating the gasoline level of your car. It would be challenging to know when to stop for gas.
"We wanted to investigate whether people with clinical depression had emotional gauges that were informative and whether they experienced emotions with the same level of specificity and differentiation as healthy people."
Filed under brain depression emotions negative emotions differentiation neuroscience psychology science
Sleep loss links to illness studied
Insomniacs know the pattern all too well. You toss and turn at night, kept awake by the rave down the street, stress from work, the snores of a significant other.
After a stretch of restless evenings, you wake up with a sore throat or a fever. You’re no longer just tired - you’re also sick.
Physicians know this pattern, too. Constant lack of sleep has long been linked with a laundry list of unpleasant conditions: cardiovascular disease, diabetes, weight gain, infectious illnesses and even death.
While it’s common knowledge that a full night of rest helps ward off ailments, what largely remains a mystery is exactly how sleep loss triggers the biological mechanisms that in turn bring about illness - like the common cold.
A 2009 study of 153 men and women, for example, showed that those who slept fewer than seven hours on average per night were about three times more likely to develop a cold than those with at least eight hours of sleep daily.
Even a small difference in sleep quality made a big difference in health, the Carnegie Mellon University study showed. Participants who actually slept less than 92 percent of the time between the time they laid down to sleep and when they woke up were 5.5 times more likely to develop a cold than those who stayed asleep 98 percent or more of the time, according to the researchers.
Read more
Filed under brain sleep sleep deprivation health illness immune system neuroscience science
Why clever crow is no bird brain
Corvus moneduloides, a native of France’s South Pacific territory of New Caledonia, is one of the stars of the avian world.
It uses its beak to craft complex tools from sticks, leaves and other material and then inserts them into deadwood or vegetation to fish out insects and other food.
Researchers led by Jolyon Troscianko of the University of Birmingham in central England used an ophthalmoscope video camera to record field of view and eye movement as three wild-caught birds examined a baited tube.
The bird’s eyes are more forward-positioned, rather than sideways-positioned, which gives it exceptional “binocular overlap,” they found.
This is the area that is viewed by both eyeballs, and is important because it helps the brain judge the distance of nearby objects.
In New Caledonian crows, the binocular overlap is 61.5 degrees, which is at least 23.9 degrees greater than in non-tool-using species of crow that the researchers also examined.
Added to this is the crow’s unusually straight bill, the investigators found.
With it, the bird can get a firm grip on a tool and bring its tip into its field of binocular vision.
"These features enable a degree of tool control that would be impossible in other corvids [crows], despite their comparative cognitive abilities," says the study, published by the journal Nature Communications.
Dolphins, elephants and other birds are among non-primates that have been found to use tools. But the New Caledonian crow occupies a privileged place because its features are so specifically adapted for tools, says the study.
Filed under crows New Caledonian crows using tools evolution cognition neuroscience science
(Image credit: chichacha)
Recent studies have linked caffeine consumption to a reduced risk of Alzheimer’s disease, and a new University of Illinois study may be able to explain how this happens.
“We have discovered a novel signal that activates the brain-based inflammation associated with neurodegenerative diseases, and caffeine appears to block its activity. This discovery may eventually lead to drugs that could reverse or inhibit mild cognitive impairment,” said Gregory Freund, a professor in the U of I’s College of Medicine and a member of the U of I’s Division of Nutritional Sciences.
Freund’s team examined the effects of caffeine on memory formation in two groups of mice—one group given caffeine, the other receiving none. The two groups were then exposed to hypoxia, simulating what happens in the brain during an interruption of breathing or blood flow, and then allowed to recover.
The caffeine-treated mice recovered their ability to form a new memory 33 percent faster than the non-caffeine-treated mice. In fact, caffeine had the same anti-inflammatory effect as blocking IL-1 signaling. IL-1 is a critical player in the inflammation associated with many neurodegenerative diseases, he said.
“It’s not surprising that the insult to the brain that the mice experienced would cause learning memory to be impaired. But how does that occur?” he wondered.
The scientists noted that the hypoxic episode triggered the release of adenosine by brain cells.
“Your cells are little powerhouses, and they run on a fuel called ATP that’s made up of molecules of adenosine. When there’s damage to a cell, adenosine is released,” he said.
Just as gasoline leaking out of a tank poses a danger to everything around it, adenosine leaking out of a cell poses a danger to its environment, he noted.
The extracellular adenosine activates the enzyme caspase-1, which triggers production of the cytokine IL-1β, a critical player in inflammation, he said.
“But caffeine blocks all the activity of adenosine and inhibits caspase-1 and the inflammation that comes with it, limiting damage to the brain and protecting it from further injury,” he added.
Caffeine’s ability to block adenosine receptors has been linked to cognitive improvement in certain neurodegenerative diseases and as a protectant against Alzheimer’s disease, he said.
“We feel that our foot is in the door now, and this research may lead to a way to reverse early cognitive impairment in the brain. We already have drugs that target certain adenosine receptors. Our work now is to determine which receptor is the most important and use a specific antagonist to that receptor,” he said.
The study appears in the Journal of Neuroscience and can be viewed online at http://www.jneurosci.org/content/32/40/13945.full
(Source: news.aces.illinois.edu)
Filed under alzheimer alzheimer's disease caffeine inflammation cognitive impairment neuroscience psychology science
The Dementia and Music Project - Chloe Meineck
This project is a culmination of two years research highlighting the advantages of listening to familiar music for dementia sufferers. This coupled with the fact that when many people move into a home they feel lost in their unfamiliar surroundings. The music box, which is all hand made, combines an interactive music player, with a memory box of co-designed special objects.
The film is Barbara talking about her life, her most important objects, music, events and her most treasured people.
Filed under brain dementia alzheimer alzheimer's disease music memory neuroscience psychology science
Is this the most unpleasant sound in the world?
The ear-splitting screech of a knife on a glass bottle has been identified as the worst sound to the human ear by scientists who studied the brain’s response to unpleasant noises.
People who listened to a series of 74 recordings while having their brain activity measured by an MRI scanner rated the sound of a fork on a glass as the second worst noise, followed by chalk on a blackboard.
The scans revealed that unpleasant sounds provoked a stronger response in the brain than pleasant ones such as the noise of blubbing water. While sounds are processed in the brain’s auditory cortex, uncomfortable noises activate the amygdala, a separate brain region which processes emotions.
The researchers studied a group of 13 volunteers and found that sounds with a frequency of between 2,000 and 5,000 Hz, the range at which our ears are the most sensitive, were the hardest to bear.
Although it remains unclear why our ears are most sensitive to this type of sound, researchers noted that screams, which we naturally find uncomfortable, fall within the same range.
Dr Sukhbinder Kumar of Newcastle University, author of the study, which was published in the Journal of Neuroscience, said: “It appears there is something very primitive kicking in. It’s a possible distress signal from the amygdala to the auditory cortex.”
His colleague Prof Tim Griffiths added: “This might be a new inroad into emotional disorders and disorders like tinnitus and migraine, in which there seems to be heightened perception of the unpleasant aspects of sounds.”
Filed under brain unpleasant sounds auditory cortex MRI brain activity emotion neuroscience psychology science
McGill researchers link genetic mutation to psychiatric disease and obesity
Deletion of brain-derived neurotrophic factor leads to major depression, anxiety, and obesity
McGill researchers have identified a small region in the genome that conclusively plays a role in the development of psychiatric disease and obesity. The key lies in the genomic deletion of brain-derived neurotrophic factor, or BDNF, a nervous system growth factor that plays a critical role in brain development.
To determine the role of BDNF in humans, Prof. Carl Ernst, from McGill’s Department of Psychiatry, Faculty of Medicine, screened over 35,000 people referred for genetic screening at clinics and over 30,000 control subjects in Canada, the U.S., and Europe. Overall, five individuals were identified with BDNF deletions, all of whom were obese, had a mild-moderate intellectual impairment, and had a mood disorder. Children had anxiety disorders, aggressive disorders, or attention deficit-hyperactivity disorder (ADHD), while post-pubescent subjects had anxiety and major depressive disorders. Subjects gradually gained weight as they aged, suggesting that obesity is a long-term process when BDNF is deleted.
"Scientists have been trying to find a region of the genome which plays a role in human psychopathology, searching for answers anywhere in our DNA that may give us a clue to the genetic causes of these types of disorders," says Prof. Ernst, who is also a researcher at the Douglas Mental Health University Institute. "Our study conclusively links a single region of the genome to mood and anxiety."
The findings, published in the Archives of General Psychiatry, reveal for the first time the link between BDNF deletion, cognition, and weight gain in humans. BDNF has been suspected to have many functions in the brain based on animal studies, but no study had shown what happens when BDNF is missing from the human genome. This research provides a step toward better understanding human behaviour and mood by clearly identifying genes that may be involved in mental disorders.
"Mood and anxiety can be seen like a house of cards. In this case, the walls of the house represent the myriad of biological interactions that maintain the structure," says Ernst, "Studying these moving parts can be tricky, so teasing apart even a single event is important. Linking a deletion in BDNF conclusively to mood and anxiety really tells us that it is possible to dissect the biological pathways involved in determining how we feel and act.
We now have a molecular pathway we are confident is involved in psychopathology,” adds Ernst, “Because thousands of genes are involved in mood, anxiety, or obesity, it allows us to root our studies on a solid foundation. All of the participants in our study had mild-moderate intellectual disability, but most people with these cognitive problems do not have psychiatric problems – so what is it about deletion of BDNF that affects mood? My hope now is to test the hypothesis that boosting BDNF in people with anxiety or depression might improve brain health.”
(Source: fiercebiotechresearch.com)
Filed under brain mental health obesity genomics neuroscience psychology science
Easier test for blindness cause
Scientists from Australia’s Vision Centre have demonstrated a quick, accurate test under lights for one of the world’s leading causes of blindness.
A new study shows that age-related macular degeneration (AMD) can be just as effectively and more rapidly and inexpensively diagnosed under bright lights, instead of requiring patients to sit for 20 minutes in a darkened room.
“AMD accounts for half of the legal blindness cases in Australia,” says Professor Ted Maddess from The Vision Centre and The Australian National University. “It affects one in seven people over the age of 50, costing the nation $2.6 billion a year. Globally, it affects 25 to 30 million people, with an annual cost of $343 billion.
“While current tests for AMD are done in the light, scientists have proposed that it might be better if the patient has their vision adapted to the dark prior to the test,” he says.
“This is because they had found that rod receptors – vision cells that we use to see in black and white and in low light – die earlier in AMD than the cone receptors we use to see in colour during the day. So it had been suggested that AMD tests would be more accurate if they were based on the health of a person’s rods.”
Filed under vision AMD macular degeneration blindness vision loss neuroscience science
How we manage to attend to multiple objects without being distracted by irrelevant information
The “tiki-taka”-style of the Spanish national football team is amazing to watch: Xavi passes to Andrès Iniesta, he just rebounds the ball once and it’s right at Xabi Alonso’s foot. The Spanish midfielders cross the field as if they run on rails, always maintaining attention on the ball and the teammates, the opponents chasing after them without a chance. An international team of scientists from the German Primate Center and McGill University in Canada, including Stefan Treue, head of the Cognitive Neuroscience Laboratory, has now uncovered how the human brain makes such excellence possible by dividing visual attention: The brain is capable of splitting its ‘attentional spotlight’ for an enhanced processing of multiple visual objects. (Neuron, doi: 10.1016/j.neuron.2011.10.013)
When we pay attention to an object, neurons responsible for this location in our field of view are more active then when they process unattended objects. But quite often we want to pay attention to multiple objects in different spatial positions, with interspersed irrelevant objects. Different theories have been proposed to account for this ability. One is, that the attentive focus is split spatially, excluding objects between the attentional spotlights. Another possibility is, that the attentional focus is zoomed out to cover all relevant objects, but including the interspersed irrelevant ones. A third possibility would be a single focus rapidly switching between the attended objects.
Studying rhesus macaques
In order to explain how such a complex ability is achieved, the neuroscientists measured the activity of individual neurons in areas of the brain involved in vision. They studied two rhesus macaques, which were trained in a visual attention task. The monkeys had learned to pay attention to two relevant objects on a screen, with an irrelevant object between them. The experiment showed, that the macaques’ neurons responded strongly to the two attended objects with only a weak response to the irrelevant stimulus in the middle. So the brain is able to spatially split visual attention and ignore the areas in between. “Our results show the enormous adaptiveness of the brain, which enables us to deal effectively with many different situations.
This multi-tasking allows us to simultaneously attend multiple objects”, Stefan Treue says. Such a powerful ability of our attentive system is one precondition for humans to become perfect football-artists but also to safely navigate in everyday traffic.
(Source: alphagalileo.org)
Filed under brain attention visual attention attentional spotlight neuron neuroscience psychology science
Neuroscientists Launch 5 Year Study of Music Education and Child Brain Development
Researchers at USC Brain and Creativity Institute will explore the effects of intense music training on cognitive development in LA Phil’s YOLA at HOLA program.
The Los Angeles Philharmonic Association, the USC Brain and Creativity Institute and Heart of Los Angeles (HOLA) are delighted to announce a longitudinal research collaboration to investigate the emotional, social and cognitive effects of musical training on childhood brain development.
The five-year research project, Effects of Early Childhood Musical Training on Brain and Cognitive Development, will offer USC researchers an important opportunity to provide new insights and add rigorous data to an emerging discussion about the role of early music engagement in learning and brain function.
Through a collaboration with the Youth Orchestra Los Angeles at Heart of Los Angeles (YOLA at HOLA) program, a partnership between the LA Phil and HOLA which provides free instruments and musical training to children from the Rampart District of Los Angeles, researchers with the USC Brain and Creativity Institute — led by acclaimed neuroscientists Hanna Damasio and Antonio Damasio – will track how children respond to music from the very onset of their exposure to systematic, high intensity music education.
Filed under brain brain development children music neuroscience psychology research science
![Why clever crow is no bird brain
Corvus moneduloides, a native of France’s South Pacific territory of New Caledonia, is one of the stars of the avian world.
It uses its beak to craft complex tools from sticks, leaves and other material and then inserts them into deadwood or vegetation to fish out insects and other food.
Researchers led by Jolyon Troscianko of the University of Birmingham in central England used an ophthalmoscope video camera to record field of view and eye movement as three wild-caught birds examined a baited tube.
The bird’s eyes are more forward-positioned, rather than sideways-positioned, which gives it exceptional “binocular overlap,” they found.
This is the area that is viewed by both eyeballs, and is important because it helps the brain judge the distance of nearby objects.
In New Caledonian crows, the binocular overlap is 61.5 degrees, which is at least 23.9 degrees greater than in non-tool-using species of crow that the researchers also examined.
Added to this is the crow’s unusually straight bill, the investigators found.
With it, the bird can get a firm grip on a tool and bring its tip into its field of binocular vision.
"These features enable a degree of tool control that would be impossible in other corvids [crows], despite their comparative cognitive abilities," says the study, published by the journal Nature Communications.
Dolphins, elephants and other birds are among non-primates that have been found to use tools. But the New Caledonian crow occupies a privileged place because its features are so specifically adapted for tools, says the study.](http://40.media.tumblr.com/tumblr_mbojlfxkA61rog5d1o1_500.jpg)
